Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study
In islet transplantation (ITx), primary graft function (PGF) or beta cell function measured early after last infusion is closely associated with long term clinical outcomes. We investigated the association between PGF and 5 year insulin independence rate in ITx and pancreas transplantation (PTx) rec...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Transplant International |
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| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/ti.2023.11950/full |
| _version_ | 1827292264519434240 |
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| author | Mikael Chetboun Mikael Chetboun Mikael Chetboun Mikael Chetboun Christophe Masset Christophe Masset Mehdi Maanaoui Mehdi Maanaoui Mehdi Maanaoui Mehdi Maanaoui Frédérique Defrance Valéry Gmyr Valéry Gmyr Valéry Gmyr Violeta Raverdy Violeta Raverdy Violeta Raverdy Violeta Raverdy Thomas Hubert Thomas Hubert Thomas Hubert Caroline Bonner Caroline Bonner Caroline Bonner Lisa Supiot Clarisse Kerleau Gilles Blancho Gilles Blancho Julien Branchereau Julien Branchereau Georges Karam Georges Karam Ismaël Chelghaf Aurélie Houzet Magali Giral Magali Giral Claire Garandeau Jacques Dantal Jacques Dantal Kristell Le Mapihan Arnaud Jannin Marc Hazzan Robert Caiazzo Robert Caiazzo Robert Caiazzo Robert Caiazzo Julie Kerr-Conte Julie Kerr-Conte Julie Kerr-Conte Marie-Christine Vantyghem Marie-Christine Vantyghem Marie-Christine Vantyghem Marie-Christine Vantyghem Diego Cantarovich François Pattou François Pattou François Pattou François Pattou |
| author_facet | Mikael Chetboun Mikael Chetboun Mikael Chetboun Mikael Chetboun Christophe Masset Christophe Masset Mehdi Maanaoui Mehdi Maanaoui Mehdi Maanaoui Mehdi Maanaoui Frédérique Defrance Valéry Gmyr Valéry Gmyr Valéry Gmyr Violeta Raverdy Violeta Raverdy Violeta Raverdy Violeta Raverdy Thomas Hubert Thomas Hubert Thomas Hubert Caroline Bonner Caroline Bonner Caroline Bonner Lisa Supiot Clarisse Kerleau Gilles Blancho Gilles Blancho Julien Branchereau Julien Branchereau Georges Karam Georges Karam Ismaël Chelghaf Aurélie Houzet Magali Giral Magali Giral Claire Garandeau Jacques Dantal Jacques Dantal Kristell Le Mapihan Arnaud Jannin Marc Hazzan Robert Caiazzo Robert Caiazzo Robert Caiazzo Robert Caiazzo Julie Kerr-Conte Julie Kerr-Conte Julie Kerr-Conte Marie-Christine Vantyghem Marie-Christine Vantyghem Marie-Christine Vantyghem Marie-Christine Vantyghem Diego Cantarovich François Pattou François Pattou François Pattou François Pattou |
| author_sort | Mikael Chetboun |
| collection | DOAJ |
| description | In islet transplantation (ITx), primary graft function (PGF) or beta cell function measured early after last infusion is closely associated with long term clinical outcomes. We investigated the association between PGF and 5 year insulin independence rate in ITx and pancreas transplantation (PTx) recipients. This retrospective multicenter study included type 1 diabetes patients who underwent ITx in Lille and PTx in Nantes from 2000 to 2022. PGF was assessed using the validated Beta2-score and compared to normoglycemic control subjects. Subsequently, the 5 year insulin independence rates, as predicted by a validated PGF-based model, were compared to the actual rates observed in ITx and PTx patients. The study enrolled 39 ITx (23 ITA, 16 IAK), 209 PTx recipients (23 PTA, 14 PAK, 172 SPK), and 56 normoglycemic controls. Mean[SD] PGF was lower after ITx (ITA 22.3[5.2], IAK 24.8[6.4], than after PTx (PTA 38.9[15.3], PAK 36.8[9.0], SPK 38.7[10.5]), and lower than mean beta-cell function measured in normoglycemic control: 36.6[4.3]. The insulin independence rates observed at 5 years after PTA and PAK aligned with PGF predictions, and was higher after SPK. Our results indicate a similar relation between PGF and 5 year insulin independence in ITx and solitary PTx, shedding new light on long-term transplantation outcomes. |
| first_indexed | 2024-04-24T12:59:05Z |
| format | Article |
| id | doaj.art-de1ea47d87a44a57b986f55e27ec6ea1 |
| institution | Directory Open Access Journal |
| issn | 1432-2277 |
| language | English |
| last_indexed | 2024-04-24T12:59:05Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Transplant International |
| spelling | doaj.art-de1ea47d87a44a57b986f55e27ec6ea12024-04-05T16:24:50ZengFrontiers Media S.A.Transplant International1432-22772023-12-013610.3389/ti.2023.1195011950Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort StudyMikael Chetboun0Mikael Chetboun1Mikael Chetboun2Mikael Chetboun3Christophe Masset4Christophe Masset5Mehdi Maanaoui6Mehdi Maanaoui7Mehdi Maanaoui8Mehdi Maanaoui9Frédérique Defrance10Valéry Gmyr11Valéry Gmyr12Valéry Gmyr13Violeta Raverdy14Violeta Raverdy15Violeta Raverdy16Violeta Raverdy17Thomas Hubert18Thomas Hubert19Thomas Hubert20Caroline Bonner21Caroline Bonner22Caroline Bonner23Lisa Supiot24Clarisse Kerleau25Gilles Blancho26Gilles Blancho27Julien Branchereau28Julien Branchereau29Georges Karam30Georges Karam31Ismaël Chelghaf32Aurélie Houzet33Magali Giral34Magali Giral35Claire Garandeau36Jacques Dantal37Jacques Dantal38Kristell Le Mapihan39Arnaud Jannin40Marc Hazzan41Robert Caiazzo42Robert Caiazzo43Robert Caiazzo44Robert Caiazzo45Julie Kerr-Conte46Julie Kerr-Conte47Julie Kerr-Conte48Marie-Christine Vantyghem49Marie-Christine Vantyghem50Marie-Christine Vantyghem51Marie-Christine Vantyghem52Diego Cantarovich53François Pattou54François Pattou55François Pattou56François Pattou57Univ Lille, U1190 - EGID, Lille, FranceInserm, U1190, Lille, FranceInstitut Pasteur de Lille, Lille, FranceCHU Lille, Department of General, Endocrine and Metabolic Surgery, Lille, FranceInstitut de Transplantation Urologie Néphrologie (ITUN), Service de Néphrologie et Immunologie clinique, CHU Nantes, Nantes, FranceNantes Université, Inserm, UMR 1064, Center for Research in Transplantation and Translational Immunology, Nantes, FranceUniv Lille, U1190 - EGID, Lille, FranceInserm, U1190, Lille, FranceInstitut Pasteur de Lille, Lille, FranceCHU Lille, Department of Nephrology, Lille, FranceCHU Lille, Department of Endocrinology, Diabetology and Metabolism, Lille, FranceUniv Lille, U1190 - EGID, Lille, FranceInserm, U1190, Lille, FranceInstitut Pasteur de Lille, Lille, FranceUniv Lille, U1190 - EGID, Lille, FranceInserm, U1190, Lille, FranceInstitut Pasteur de Lille, Lille, FranceCHU Lille, Department of General, Endocrine and Metabolic Surgery, Lille, FranceUniv Lille, U1190 - EGID, Lille, FranceInserm, U1190, Lille, FranceInstitut Pasteur de Lille, Lille, FranceUniv Lille, U1190 - EGID, Lille, FranceInserm, U1190, Lille, FranceInstitut Pasteur de Lille, Lille, FranceNantes Université, Inserm, UMR 1064, Center for Research in Transplantation and Translational Immunology, Nantes, FranceInstitut de Transplantation Urologie Néphrologie (ITUN), Service de Néphrologie et Immunologie clinique, CHU Nantes, Nantes, FranceInstitut de Transplantation Urologie Néphrologie (ITUN), Service de Néphrologie et Immunologie clinique, CHU Nantes, Nantes, FranceNantes Université, Inserm, UMR 1064, Center for Research in Transplantation and Translational Immunology, Nantes, FranceInstitut de Transplantation Urologie Néphrologie (ITUN), Service de Néphrologie et Immunologie clinique, CHU Nantes, Nantes, FranceNantes Université, Inserm, UMR 1064, Center for Research in Transplantation and Translational Immunology, Nantes, FranceInstitut de Transplantation Urologie Néphrologie (ITUN), Service de Néphrologie et Immunologie clinique, CHU Nantes, Nantes, FranceNantes Université, Inserm, UMR 1064, Center for Research in Transplantation and Translational Immunology, Nantes, FranceInstitut de Transplantation Urologie Néphrologie (ITUN), Service de Néphrologie et Immunologie clinique, CHU Nantes, Nantes, FranceInstitut de Transplantation Urologie Néphrologie (ITUN), Service de Néphrologie et Immunologie clinique, CHU Nantes, Nantes, FranceInstitut de Transplantation Urologie Néphrologie (ITUN), Service de Néphrologie et Immunologie clinique, CHU Nantes, Nantes, FranceNantes Université, Inserm, UMR 1064, Center for Research in Transplantation and Translational Immunology, Nantes, FranceInstitut de Transplantation Urologie Néphrologie (ITUN), Service de Néphrologie et Immunologie clinique, CHU Nantes, Nantes, FranceInstitut de Transplantation Urologie Néphrologie (ITUN), Service de Néphrologie et Immunologie clinique, CHU Nantes, Nantes, FranceNantes Université, Inserm, UMR 1064, Center for Research in Transplantation and Translational Immunology, Nantes, FranceCHU Lille, Department of Endocrinology, Diabetology and Metabolism, Lille, FranceCHU Lille, Department of Endocrinology, Diabetology and Metabolism, Lille, FranceCHU Lille, Department of Nephrology, Lille, FranceUniv Lille, U1190 - EGID, Lille, FranceInserm, U1190, Lille, FranceInstitut Pasteur de Lille, Lille, FranceCHU Lille, Department of General, Endocrine and Metabolic Surgery, Lille, FranceUniv Lille, U1190 - EGID, Lille, FranceInserm, U1190, Lille, FranceInstitut Pasteur de Lille, Lille, FranceUniv Lille, U1190 - EGID, Lille, FranceInserm, U1190, Lille, FranceInstitut Pasteur de Lille, Lille, FranceCHU Lille, Department of Endocrinology, Diabetology and Metabolism, Lille, FranceInstitut de Transplantation Urologie Néphrologie (ITUN), Service de Néphrologie et Immunologie clinique, CHU Nantes, Nantes, FranceUniv Lille, U1190 - EGID, Lille, FranceInserm, U1190, Lille, FranceInstitut Pasteur de Lille, Lille, FranceCHU Lille, Department of General, Endocrine and Metabolic Surgery, Lille, FranceIn islet transplantation (ITx), primary graft function (PGF) or beta cell function measured early after last infusion is closely associated with long term clinical outcomes. We investigated the association between PGF and 5 year insulin independence rate in ITx and pancreas transplantation (PTx) recipients. This retrospective multicenter study included type 1 diabetes patients who underwent ITx in Lille and PTx in Nantes from 2000 to 2022. PGF was assessed using the validated Beta2-score and compared to normoglycemic control subjects. Subsequently, the 5 year insulin independence rates, as predicted by a validated PGF-based model, were compared to the actual rates observed in ITx and PTx patients. The study enrolled 39 ITx (23 ITA, 16 IAK), 209 PTx recipients (23 PTA, 14 PAK, 172 SPK), and 56 normoglycemic controls. Mean[SD] PGF was lower after ITx (ITA 22.3[5.2], IAK 24.8[6.4], than after PTx (PTA 38.9[15.3], PAK 36.8[9.0], SPK 38.7[10.5]), and lower than mean beta-cell function measured in normoglycemic control: 36.6[4.3]. The insulin independence rates observed at 5 years after PTA and PAK aligned with PGF predictions, and was higher after SPK. Our results indicate a similar relation between PGF and 5 year insulin independence in ITx and solitary PTx, shedding new light on long-term transplantation outcomes.https://www.frontierspartnerships.org/articles/10.3389/ti.2023.11950/fullinsulin independencepredictionislet transplantpancreas allograftprimary graft function |
| spellingShingle | Mikael Chetboun Mikael Chetboun Mikael Chetboun Mikael Chetboun Christophe Masset Christophe Masset Mehdi Maanaoui Mehdi Maanaoui Mehdi Maanaoui Mehdi Maanaoui Frédérique Defrance Valéry Gmyr Valéry Gmyr Valéry Gmyr Violeta Raverdy Violeta Raverdy Violeta Raverdy Violeta Raverdy Thomas Hubert Thomas Hubert Thomas Hubert Caroline Bonner Caroline Bonner Caroline Bonner Lisa Supiot Clarisse Kerleau Gilles Blancho Gilles Blancho Julien Branchereau Julien Branchereau Georges Karam Georges Karam Ismaël Chelghaf Aurélie Houzet Magali Giral Magali Giral Claire Garandeau Jacques Dantal Jacques Dantal Kristell Le Mapihan Arnaud Jannin Marc Hazzan Robert Caiazzo Robert Caiazzo Robert Caiazzo Robert Caiazzo Julie Kerr-Conte Julie Kerr-Conte Julie Kerr-Conte Marie-Christine Vantyghem Marie-Christine Vantyghem Marie-Christine Vantyghem Marie-Christine Vantyghem Diego Cantarovich François Pattou François Pattou François Pattou François Pattou Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study Transplant International insulin independence prediction islet transplant pancreas allograft primary graft function |
| title | Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study |
| title_full | Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study |
| title_fullStr | Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study |
| title_full_unstemmed | Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study |
| title_short | Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study |
| title_sort | primary graft function and 5 year insulin independence after pancreas and islet transplantation for type 1 diabetes a retrospective parallel cohort study |
| topic | insulin independence prediction islet transplant pancreas allograft primary graft function |
| url | https://www.frontierspartnerships.org/articles/10.3389/ti.2023.11950/full |
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