Large effects on body mass index and insulin resistance of fat mass and obesity associated gene <it>(FTO) </it>variants in patients with polycystic ovary syndrome (PCOS)
<p>Abstract</p> <p>Background</p> <p>The polycystic ovary syndrome (PCOS), a common endocrine disorder in women of child-bearing age, mainly characterised by chronic anovulation and hyperandrogenism, is often associated with insulin resistance (IR) and obesity. Its etio...
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| Format: | Article |
| Language: | English |
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BMC
2010-01-01
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| Series: | BMC Medical Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2350/11/12 |
| _version_ | 1818884013680492544 |
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| author | Kimmig Rainer Vogel Carla Grallert Harald Scherag Susann Dietz Tiina Lahner Harald Hahn Susanne Janssen Onno Scherag André Tan Susanne Illig Thomas Mann Klaus Hebebrand Johannes Hinney Anke |
| author_facet | Kimmig Rainer Vogel Carla Grallert Harald Scherag Susann Dietz Tiina Lahner Harald Hahn Susanne Janssen Onno Scherag André Tan Susanne Illig Thomas Mann Klaus Hebebrand Johannes Hinney Anke |
| author_sort | Kimmig Rainer |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The polycystic ovary syndrome (PCOS), a common endocrine disorder in women of child-bearing age, mainly characterised by chronic anovulation and hyperandrogenism, is often associated with insulin resistance (IR) and obesity. Its etiology and the role of IR and obesity in PCOS are not fully understood. We examined the influence of validated genetic variants conferring susceptibility to obesity and/or type 2 diabetes mellitus (T2DM) on metabolic and PCOS-specific traits in patients with PCOS.</p> <p>Methods</p> <p>We conducted an association study in 386 patients with PCOS (defined by the Rotterdam-criteria) using single nucleotide polymorphisms (SNPs) in or in proximity to the fat mass and obesity associated gene <it>(FTO</it>), insulin-induced gene-2 (<it>INSIG2</it>), transcription factor 7-like 2 gene (<it>TCF7L2</it>) and melanocortin 4 receptor gene (<it>MC4R</it>). To compare the effect of <it>FTO </it>obesity risk alleles on BMI in patients with PCOS to unselected females of the same age range we genotyped 1,971 females from the population-based KORA-S4 study (<it>Kooperative Gesundheitsforschung im Raum Augsburg</it>, Survey 4).</p> <p>Results</p> <p>The <it>FTO </it>risk allele was associated with IR traits and measures of increased body weight. In addition, the <it>TCF7L2 </it>SNP was associated with body weight traits. For the SNPs in the vicinity of <it>INSIG2 </it>and <it>MC4R </it>and for the other examined phenotypes there was no evidence for an association. In PCOS the observed per risk allele effect of <it>FTO </it>intron 1 SNP rs9939609 on BMI was +1.56 kg/m<sup>2</sup>, whereas it was +0.46 kg/m<sup>2 </sup>in females of the same age range from the general population as shown previously.</p> <p>Conclusion</p> <p>The stronger effect on body weight of the <it>FTO </it>SNP in PCOS might well have implications for the etiology of the disease.</p> |
| first_indexed | 2024-12-19T15:42:48Z |
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| id | doaj.art-de1f6e0dd4f04d878762be7282a87f34 |
| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-19T15:42:48Z |
| publishDate | 2010-01-01 |
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| spelling | doaj.art-de1f6e0dd4f04d878762be7282a87f342022-12-21T20:15:26ZengBMCBMC Medical Genetics1471-23502010-01-011111210.1186/1471-2350-11-12Large effects on body mass index and insulin resistance of fat mass and obesity associated gene <it>(FTO) </it>variants in patients with polycystic ovary syndrome (PCOS)Kimmig RainerVogel CarlaGrallert HaraldScherag SusannDietz TiinaLahner HaraldHahn SusanneJanssen OnnoScherag AndréTan SusanneIllig ThomasMann KlausHebebrand JohannesHinney Anke<p>Abstract</p> <p>Background</p> <p>The polycystic ovary syndrome (PCOS), a common endocrine disorder in women of child-bearing age, mainly characterised by chronic anovulation and hyperandrogenism, is often associated with insulin resistance (IR) and obesity. Its etiology and the role of IR and obesity in PCOS are not fully understood. We examined the influence of validated genetic variants conferring susceptibility to obesity and/or type 2 diabetes mellitus (T2DM) on metabolic and PCOS-specific traits in patients with PCOS.</p> <p>Methods</p> <p>We conducted an association study in 386 patients with PCOS (defined by the Rotterdam-criteria) using single nucleotide polymorphisms (SNPs) in or in proximity to the fat mass and obesity associated gene <it>(FTO</it>), insulin-induced gene-2 (<it>INSIG2</it>), transcription factor 7-like 2 gene (<it>TCF7L2</it>) and melanocortin 4 receptor gene (<it>MC4R</it>). To compare the effect of <it>FTO </it>obesity risk alleles on BMI in patients with PCOS to unselected females of the same age range we genotyped 1,971 females from the population-based KORA-S4 study (<it>Kooperative Gesundheitsforschung im Raum Augsburg</it>, Survey 4).</p> <p>Results</p> <p>The <it>FTO </it>risk allele was associated with IR traits and measures of increased body weight. In addition, the <it>TCF7L2 </it>SNP was associated with body weight traits. For the SNPs in the vicinity of <it>INSIG2 </it>and <it>MC4R </it>and for the other examined phenotypes there was no evidence for an association. In PCOS the observed per risk allele effect of <it>FTO </it>intron 1 SNP rs9939609 on BMI was +1.56 kg/m<sup>2</sup>, whereas it was +0.46 kg/m<sup>2 </sup>in females of the same age range from the general population as shown previously.</p> <p>Conclusion</p> <p>The stronger effect on body weight of the <it>FTO </it>SNP in PCOS might well have implications for the etiology of the disease.</p>http://www.biomedcentral.com/1471-2350/11/12 |
| spellingShingle | Kimmig Rainer Vogel Carla Grallert Harald Scherag Susann Dietz Tiina Lahner Harald Hahn Susanne Janssen Onno Scherag André Tan Susanne Illig Thomas Mann Klaus Hebebrand Johannes Hinney Anke Large effects on body mass index and insulin resistance of fat mass and obesity associated gene <it>(FTO) </it>variants in patients with polycystic ovary syndrome (PCOS) BMC Medical Genetics |
| title | Large effects on body mass index and insulin resistance of fat mass and obesity associated gene <it>(FTO) </it>variants in patients with polycystic ovary syndrome (PCOS) |
| title_full | Large effects on body mass index and insulin resistance of fat mass and obesity associated gene <it>(FTO) </it>variants in patients with polycystic ovary syndrome (PCOS) |
| title_fullStr | Large effects on body mass index and insulin resistance of fat mass and obesity associated gene <it>(FTO) </it>variants in patients with polycystic ovary syndrome (PCOS) |
| title_full_unstemmed | Large effects on body mass index and insulin resistance of fat mass and obesity associated gene <it>(FTO) </it>variants in patients with polycystic ovary syndrome (PCOS) |
| title_short | Large effects on body mass index and insulin resistance of fat mass and obesity associated gene <it>(FTO) </it>variants in patients with polycystic ovary syndrome (PCOS) |
| title_sort | large effects on body mass index and insulin resistance of fat mass and obesity associated gene it fto it variants in patients with polycystic ovary syndrome pcos |
| url | http://www.biomedcentral.com/1471-2350/11/12 |
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