Causal associations between genetically determined common psychiatric disorders and the risk of falls: evidence from Mendelian randomization
Abstract Background The causal associations between psychiatric disorders and falls risk remains uncertain. Consequently, this study aimed to explore the causal relationship between genetically determined three common psychiatric disorders and the risk of falls based on Mendelian randomization (MR)....
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01502-y |
| _version_ | 1797398106411630592 |
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| author | Haitao Zhang Chuanglong Xu Chunchun Yuan Binhao Shi Wenhao Zhu Hongyu Wang Furui Fu Dezhi Tang Yongjun Wang |
| author_facet | Haitao Zhang Chuanglong Xu Chunchun Yuan Binhao Shi Wenhao Zhu Hongyu Wang Furui Fu Dezhi Tang Yongjun Wang |
| author_sort | Haitao Zhang |
| collection | DOAJ |
| description | Abstract Background The causal associations between psychiatric disorders and falls risk remains uncertain. Consequently, this study aimed to explore the causal relationship between genetically determined three common psychiatric disorders and the risk of falls based on Mendelian randomization (MR). Methods The genome-wide association study (GWAS) data for schizophrenia (SCZ) (N = 320,404), major depressive disorder (MDD) (N = 480,359), and Alzheimer's disease (AD) (N = 63,926) were obtained as exposures. The GWAS data for falls risk (N = 451,179) was obtained as outcome. Univariate Mendelian randomization (UVMR) was used to evaluate the direct causal relationship between SCZ, MDD, AD, and risk of falls. Inverse variance weighting (IVW) was used as the primary analysis method. Sensitivity analysis was performed to assess the validity of the casualty. Multivariate Mendelian randomization (MVMR) analysis was conducted after adjusting body mass index and smoking initiation. Mediating MR was conducted to calculate the mediating effects of potential intermediaries. Results UVMR analysis showed that SCZ (OR 1.02, 95% CI 1.01–1.04, p = 8.03E−03) and MDD (OR 1.15, 95% CI 1.08–1.22, p = 1.38E−05) were positively associated with the risk of falls. Sensitivity analysis results were reliable and robust. MVMR results indicated that the relationship between MDD and SCZ and falls risk remained significant. Mediating MR results demonstrated that smoking initiation mediated partial causal effect of SCZ (0.65%, P = 0.03) and MDD (14.82%, P = 2.02E−03) on risk of falls. Conclusions This study provides genetic evidence for a causal relationship of individuals with SCZ and MDD on an increased risk of falls. Healthcare providers should be aware of the risk of falls in MDD and SCZ patients and develop strategies accordingly. |
| first_indexed | 2024-03-09T01:20:54Z |
| format | Article |
| id | doaj.art-de1f9a437cee4a5894a7c2636580bc8e |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-09T01:20:54Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-de1f9a437cee4a5894a7c2636580bc8e2023-12-10T12:12:14ZengBMCEuropean Journal of Medical Research2047-783X2023-12-0128111110.1186/s40001-023-01502-yCausal associations between genetically determined common psychiatric disorders and the risk of falls: evidence from Mendelian randomizationHaitao Zhang0Chuanglong Xu1Chunchun Yuan2Binhao Shi3Wenhao Zhu4Hongyu Wang5Furui Fu6Dezhi Tang7Yongjun Wang8Longhua Hospital, Shanghai University of Traditional Chinese MedicineNingxia Hospital of Traditional Chinese Medicine and Chinese Medicine Research InstituteLonghua Hospital, Shanghai University of Traditional Chinese MedicineShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineLonghua Hospital, Shanghai University of Traditional Chinese MedicineLonghua Hospital, Shanghai University of Traditional Chinese MedicineLonghua Hospital, Shanghai University of Traditional Chinese MedicineLonghua Hospital, Shanghai University of Traditional Chinese MedicineLonghua Hospital, Shanghai University of Traditional Chinese MedicineAbstract Background The causal associations between psychiatric disorders and falls risk remains uncertain. Consequently, this study aimed to explore the causal relationship between genetically determined three common psychiatric disorders and the risk of falls based on Mendelian randomization (MR). Methods The genome-wide association study (GWAS) data for schizophrenia (SCZ) (N = 320,404), major depressive disorder (MDD) (N = 480,359), and Alzheimer's disease (AD) (N = 63,926) were obtained as exposures. The GWAS data for falls risk (N = 451,179) was obtained as outcome. Univariate Mendelian randomization (UVMR) was used to evaluate the direct causal relationship between SCZ, MDD, AD, and risk of falls. Inverse variance weighting (IVW) was used as the primary analysis method. Sensitivity analysis was performed to assess the validity of the casualty. Multivariate Mendelian randomization (MVMR) analysis was conducted after adjusting body mass index and smoking initiation. Mediating MR was conducted to calculate the mediating effects of potential intermediaries. Results UVMR analysis showed that SCZ (OR 1.02, 95% CI 1.01–1.04, p = 8.03E−03) and MDD (OR 1.15, 95% CI 1.08–1.22, p = 1.38E−05) were positively associated with the risk of falls. Sensitivity analysis results were reliable and robust. MVMR results indicated that the relationship between MDD and SCZ and falls risk remained significant. Mediating MR results demonstrated that smoking initiation mediated partial causal effect of SCZ (0.65%, P = 0.03) and MDD (14.82%, P = 2.02E−03) on risk of falls. Conclusions This study provides genetic evidence for a causal relationship of individuals with SCZ and MDD on an increased risk of falls. Healthcare providers should be aware of the risk of falls in MDD and SCZ patients and develop strategies accordingly.https://doi.org/10.1186/s40001-023-01502-ySchizophreniaMajor depressive disorderAlzheimer’s diseaseFallsCausal associationsMendelian randomization |
| spellingShingle | Haitao Zhang Chuanglong Xu Chunchun Yuan Binhao Shi Wenhao Zhu Hongyu Wang Furui Fu Dezhi Tang Yongjun Wang Causal associations between genetically determined common psychiatric disorders and the risk of falls: evidence from Mendelian randomization European Journal of Medical Research Schizophrenia Major depressive disorder Alzheimer’s disease Falls Causal associations Mendelian randomization |
| title | Causal associations between genetically determined common psychiatric disorders and the risk of falls: evidence from Mendelian randomization |
| title_full | Causal associations between genetically determined common psychiatric disorders and the risk of falls: evidence from Mendelian randomization |
| title_fullStr | Causal associations between genetically determined common psychiatric disorders and the risk of falls: evidence from Mendelian randomization |
| title_full_unstemmed | Causal associations between genetically determined common psychiatric disorders and the risk of falls: evidence from Mendelian randomization |
| title_short | Causal associations between genetically determined common psychiatric disorders and the risk of falls: evidence from Mendelian randomization |
| title_sort | causal associations between genetically determined common psychiatric disorders and the risk of falls evidence from mendelian randomization |
| topic | Schizophrenia Major depressive disorder Alzheimer’s disease Falls Causal associations Mendelian randomization |
| url | https://doi.org/10.1186/s40001-023-01502-y |
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