The Use of Soy Isoflavones in the Treatment of Prostate Cancer: A Focus on the Cellular Effects
A possible link between diet and cancer has long been considered, with growing interest in phytochemicals. Soy isoflavones have been associated with a reduced risk of prostate cancer in Asian populations. Of the soy isoflavones, genistein and daidzein, in particular, have been studied, but recently,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/23/4856 |
| _version_ | 1797399803882110976 |
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| author | Hans Van der Eecken Steven Joniau Charlien Berghen Kato Rans Gert De Meerleer |
| author_facet | Hans Van der Eecken Steven Joniau Charlien Berghen Kato Rans Gert De Meerleer |
| author_sort | Hans Van der Eecken |
| collection | DOAJ |
| description | A possible link between diet and cancer has long been considered, with growing interest in phytochemicals. Soy isoflavones have been associated with a reduced risk of prostate cancer in Asian populations. Of the soy isoflavones, genistein and daidzein, in particular, have been studied, but recently, equol as a derivative has gained interest because it is more biologically potent. Different mechanisms of action have already been studied for the different isoflavones in multiple conditions, such as breast, gastrointestinal, and urogenital cancers. Many of these mechanisms of action could also be demonstrated in the prostate, both in vitro and in vivo. This review focuses on the known mechanisms of action at the cellular level and compares them between genistein, daidzein, and equol. These include androgen- and estrogen-mediated pathways, regulation of the cell cycle and cell proliferation, apoptosis, angiogenesis, and metastasis. In addition, antioxidant and anti-inflammatory effects and epigenetics are addressed. |
| first_indexed | 2024-03-09T01:45:23Z |
| format | Article |
| id | doaj.art-de1ff314621d46759494dde3f9b80845 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T01:45:23Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-de1ff314621d46759494dde3f9b808452023-12-08T15:23:08ZengMDPI AGNutrients2072-66432023-11-011523485610.3390/nu15234856The Use of Soy Isoflavones in the Treatment of Prostate Cancer: A Focus on the Cellular EffectsHans Van der Eecken0Steven Joniau1Charlien Berghen2Kato Rans3Gert De Meerleer4Department of Urology, University Hospital Brussels, 1090 Brussels, BelgiumDepartment of Urology, University Hospitals Leuven, 3000 Leuven, BelgiumDepartment of Radiation Oncology, University Hospitals Leuven, 3000 Leuven, BelgiumDepartment of Radiation Oncology, University Hospitals Leuven, 3000 Leuven, BelgiumDepartment of Radiation Oncology, University Hospitals Leuven, 3000 Leuven, BelgiumA possible link between diet and cancer has long been considered, with growing interest in phytochemicals. Soy isoflavones have been associated with a reduced risk of prostate cancer in Asian populations. Of the soy isoflavones, genistein and daidzein, in particular, have been studied, but recently, equol as a derivative has gained interest because it is more biologically potent. Different mechanisms of action have already been studied for the different isoflavones in multiple conditions, such as breast, gastrointestinal, and urogenital cancers. Many of these mechanisms of action could also be demonstrated in the prostate, both in vitro and in vivo. This review focuses on the known mechanisms of action at the cellular level and compares them between genistein, daidzein, and equol. These include androgen- and estrogen-mediated pathways, regulation of the cell cycle and cell proliferation, apoptosis, angiogenesis, and metastasis. In addition, antioxidant and anti-inflammatory effects and epigenetics are addressed.https://www.mdpi.com/2072-6643/15/23/4856isoflavonegenisteindaidzeinequolprostate cancer |
| spellingShingle | Hans Van der Eecken Steven Joniau Charlien Berghen Kato Rans Gert De Meerleer The Use of Soy Isoflavones in the Treatment of Prostate Cancer: A Focus on the Cellular Effects Nutrients isoflavone genistein daidzein equol prostate cancer |
| title | The Use of Soy Isoflavones in the Treatment of Prostate Cancer: A Focus on the Cellular Effects |
| title_full | The Use of Soy Isoflavones in the Treatment of Prostate Cancer: A Focus on the Cellular Effects |
| title_fullStr | The Use of Soy Isoflavones in the Treatment of Prostate Cancer: A Focus on the Cellular Effects |
| title_full_unstemmed | The Use of Soy Isoflavones in the Treatment of Prostate Cancer: A Focus on the Cellular Effects |
| title_short | The Use of Soy Isoflavones in the Treatment of Prostate Cancer: A Focus on the Cellular Effects |
| title_sort | use of soy isoflavones in the treatment of prostate cancer a focus on the cellular effects |
| topic | isoflavone genistein daidzein equol prostate cancer |
| url | https://www.mdpi.com/2072-6643/15/23/4856 |
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