Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development
ABSTRACTIt is known to all that Wnt signaling pathway plays an important role in the early development of tooth. Our previous research found that Wnt signaling pathway played crucial roles in dental development, and mutations in antagonist of Wnt signaling pathway may lead to the formation of supern...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Organogenesis |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15476278.2023.2212583 |
| _version_ | 1797447748415389696 |
|---|---|
| author | Yuhan Song Fujie Song Xuan Xiao Zhifeng Song Shangfeng Liu |
| author_facet | Yuhan Song Fujie Song Xuan Xiao Zhifeng Song Shangfeng Liu |
| author_sort | Yuhan Song |
| collection | DOAJ |
| description | ABSTRACTIt is known to all that Wnt signaling pathway plays an important role in the early development of tooth. Our previous research found that Wnt signaling pathway played crucial roles in dental development, and mutations in antagonist of Wnt signaling pathway may lead to the formation of supernumerary teeth. However, the expression pattern of Wnt signaling molecules in early development of tooth, especially genes with stage specificity, remains unclear. Hence, we applied RNA-seq analysis to determine the expression levels of wnt signal molecules at five different stages of rat first molar tooth germ. In addition, after literature review we summarized the function of Wnt signaling molecules during tooth development and the relationship between Wnt signaling molecules variation and tooth agenesis. Our research may have implications for exploring the role of Wnt signaling molecules in different stages of tooth development. |
| first_indexed | 2024-03-09T14:00:25Z |
| format | Article |
| id | doaj.art-de2005d36aa446b187626778a8380e08 |
| institution | Directory Open Access Journal |
| issn | 1547-6278 1555-8592 |
| language | English |
| last_indexed | 2024-03-09T14:00:25Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Organogenesis |
| spelling | doaj.art-de2005d36aa446b187626778a8380e082023-11-30T09:24:33ZengTaylor & Francis GroupOrganogenesis1547-62781555-85922023-12-0119110.1080/15476278.2023.2212583Expression Levels of WNT Signaling Pathway Genes During Early Tooth DevelopmentYuhan Song0Fujie Song1Xuan Xiao2Zhifeng Song3Shangfeng Liu4Department of oral mucosa, Shanghai Stomatological Hospital, Fudan University, Shanghai, P. R. ChinaDepartment of first dental clinic, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, ChinaDepartment of oral mucosa, Shanghai Stomatological Hospital, Fudan University, Shanghai, P. R. ChinaDepartment of oral mucosa, Shanghai Stomatological Hospital, Fudan University, Shanghai, P. R. ChinaShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai, P. R. ChinaABSTRACTIt is known to all that Wnt signaling pathway plays an important role in the early development of tooth. Our previous research found that Wnt signaling pathway played crucial roles in dental development, and mutations in antagonist of Wnt signaling pathway may lead to the formation of supernumerary teeth. However, the expression pattern of Wnt signaling molecules in early development of tooth, especially genes with stage specificity, remains unclear. Hence, we applied RNA-seq analysis to determine the expression levels of wnt signal molecules at five different stages of rat first molar tooth germ. In addition, after literature review we summarized the function of Wnt signaling molecules during tooth development and the relationship between Wnt signaling molecules variation and tooth agenesis. Our research may have implications for exploring the role of Wnt signaling molecules in different stages of tooth development.https://www.tandfonline.com/doi/10.1080/15476278.2023.2212583Early tooth developmentexpression patternsRNA-seqtooth agenesisWnt signaling pathway |
| spellingShingle | Yuhan Song Fujie Song Xuan Xiao Zhifeng Song Shangfeng Liu Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development Organogenesis Early tooth development expression patterns RNA-seq tooth agenesis Wnt signaling pathway |
| title | Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development |
| title_full | Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development |
| title_fullStr | Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development |
| title_full_unstemmed | Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development |
| title_short | Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development |
| title_sort | expression levels of wnt signaling pathway genes during early tooth development |
| topic | Early tooth development expression patterns RNA-seq tooth agenesis Wnt signaling pathway |
| url | https://www.tandfonline.com/doi/10.1080/15476278.2023.2212583 |
| work_keys_str_mv | AT yuhansong expressionlevelsofwntsignalingpathwaygenesduringearlytoothdevelopment AT fujiesong expressionlevelsofwntsignalingpathwaygenesduringearlytoothdevelopment AT xuanxiao expressionlevelsofwntsignalingpathwaygenesduringearlytoothdevelopment AT zhifengsong expressionlevelsofwntsignalingpathwaygenesduringearlytoothdevelopment AT shangfengliu expressionlevelsofwntsignalingpathwaygenesduringearlytoothdevelopment |