Extracellular Vesicles Released after Doxorubicin Treatment in Rats Protect Cardiomyocytes from Oxidative Damage and Induce Pro-Inflammatory Gene Expression in Macrophages

Extracellular Vesicles Released after Doxorubicin Treatment in Rats Protect Cardiomyocytes from Oxidative Damage and Induce Pro-Inflammatory Gene Expression in Macrophages

Doxorubicin (DOXO)-induced cardiomyopathy (DIC) is a lethal complication in cancer patients. Major mechanisms of DIC involve oxidative stress in cardiomyocytes and hyperactivated immune response. Extracellular vesicles (EVs) mediate cell–cell communication during oxidative stress. However, functions...

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Bibliographic Details
Main Authors: Chontida Yarana, Panjaree Siwaponanan, Chayodom Maneechote, Thawatchai Khuanjing, Benjamin Ongnok, Nanthip Prathumsap, Siriporn C. Chattipakorn, Nipon Chattipakorn, Kovit Pattanapanyasat
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
doxorubicin
cardiotoxicity
extracellular vesicle
oxidative stress
macrophage
Online Access:https://www.mdpi.com/1422-0067/23/21/13465

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