Proton beam therapy in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus
Abstract Background To evaluate proton beam therapy (PBT) in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus (NPSCC). Methods The cases in this study included T3 and T4 NPSCC without distant metastases that were treated at our center using PB...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13014-023-02296-3 |
| _version_ | 1797789666108243968 |
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| author | Takashi Saito Masahiro Nakayama Kayoko Ohnishi Shuho Tanaka Masatoshi Nakamura Motohiro Murakami Shin Matsumoto Keiichiro Baba Keitaro Fujii Masashi Mizumoto Keiji Tabuchi Hideyuki Sakurai |
| author_facet | Takashi Saito Masahiro Nakayama Kayoko Ohnishi Shuho Tanaka Masatoshi Nakamura Motohiro Murakami Shin Matsumoto Keiichiro Baba Keitaro Fujii Masashi Mizumoto Keiji Tabuchi Hideyuki Sakurai |
| author_sort | Takashi Saito |
| collection | DOAJ |
| description | Abstract Background To evaluate proton beam therapy (PBT) in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus (NPSCC). Methods The cases in this study included T3 and T4 NPSCC without distant metastases that were treated at our center using PBT between July 2003 and December 2020. These cases were classified into 3 groups based on resectability and treatment strategy: surgery followed by postoperative PBT (group A); those indicated to be resectable, but the patient refused surgery and received radical PBT (group B); and those declared unresectable based on the extent of the tumor and treated with radical PBT (group C). Results The study included 37 cases, with 10, 9 and 18 in groups A, B and C, respectively. The median follow-up period in surviving patients was 4.4 years (range 1.0-12.3 years). The 4-year overall survival (OS), progression-free survival (PFS), and local control (LC) rates were 58%, 43% and 58% for all patients; 90%, 70% and 80% in group A, 89%, 78% and 89% in group B; and 24%, 11% and 24% in group C. There were significant differences in OS (p = 0.0028) and PFS (p = 0.009) between groups A and C; and in OS (p = 0.0027), PFS (p = 0.0045) and LC (p = 0.0075) between groups B and C. Conclusions PBT gave favorable outcomes in multimodal treatment for resectable locally advanced NPSCC, including surgery followed by postoperative PBT and radical PBT with concurrent chemotherapy. The prognosis for unresectable NPSCC was extremely poor, and reconsideration of treatment strategies, such as more active use of induction chemotherapy, may improve outcomes. |
| first_indexed | 2024-03-13T01:53:54Z |
| format | Article |
| id | doaj.art-de21415493f142cbbe2fadacc3fec5e1 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-03-13T01:53:54Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-de21415493f142cbbe2fadacc3fec5e12023-07-02T11:22:09ZengBMCRadiation Oncology1748-717X2023-06-011811810.1186/s13014-023-02296-3Proton beam therapy in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinusTakashi Saito0Masahiro Nakayama1Kayoko Ohnishi2Shuho Tanaka3Masatoshi Nakamura4Motohiro Murakami5Shin Matsumoto6Keiichiro Baba7Keitaro Fujii8Masashi Mizumoto9Keiji Tabuchi10Hideyuki Sakurai11Department of Radiation Oncology, University of TsukubaDepartment of Otolaryngology, Head and Neck Surgery, University of TsukubaDepartment of Radiology, School of Medicine, International University of Health and WelfareDepartment of Otolaryngology, Head and Neck Surgery, University of TsukubaDepartment of Radiation Oncology, University of TsukubaDepartment of Radiation Oncology, University of TsukubaDepartment of Otolaryngology, Head and Neck Surgery, University of TsukubaDepartment of Radiation Oncology, University of TsukubaDepartment of Otolaryngology, Head and Neck Surgery, University of TsukubaDepartment of Radiation Oncology, University of TsukubaDepartment of Otolaryngology, Head and Neck Surgery, University of TsukubaDepartment of Radiation Oncology, University of TsukubaAbstract Background To evaluate proton beam therapy (PBT) in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus (NPSCC). Methods The cases in this study included T3 and T4 NPSCC without distant metastases that were treated at our center using PBT between July 2003 and December 2020. These cases were classified into 3 groups based on resectability and treatment strategy: surgery followed by postoperative PBT (group A); those indicated to be resectable, but the patient refused surgery and received radical PBT (group B); and those declared unresectable based on the extent of the tumor and treated with radical PBT (group C). Results The study included 37 cases, with 10, 9 and 18 in groups A, B and C, respectively. The median follow-up period in surviving patients was 4.4 years (range 1.0-12.3 years). The 4-year overall survival (OS), progression-free survival (PFS), and local control (LC) rates were 58%, 43% and 58% for all patients; 90%, 70% and 80% in group A, 89%, 78% and 89% in group B; and 24%, 11% and 24% in group C. There were significant differences in OS (p = 0.0028) and PFS (p = 0.009) between groups A and C; and in OS (p = 0.0027), PFS (p = 0.0045) and LC (p = 0.0075) between groups B and C. Conclusions PBT gave favorable outcomes in multimodal treatment for resectable locally advanced NPSCC, including surgery followed by postoperative PBT and radical PBT with concurrent chemotherapy. The prognosis for unresectable NPSCC was extremely poor, and reconsideration of treatment strategies, such as more active use of induction chemotherapy, may improve outcomes.https://doi.org/10.1186/s13014-023-02296-3Proton beam therapySquamous cell carcinomaNasal cavityParanasal sinusMultimodal treatmentOutcomes |
| spellingShingle | Takashi Saito Masahiro Nakayama Kayoko Ohnishi Shuho Tanaka Masatoshi Nakamura Motohiro Murakami Shin Matsumoto Keiichiro Baba Keitaro Fujii Masashi Mizumoto Keiji Tabuchi Hideyuki Sakurai Proton beam therapy in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus Radiation Oncology Proton beam therapy Squamous cell carcinoma Nasal cavity Paranasal sinus Multimodal treatment Outcomes |
| title | Proton beam therapy in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus |
| title_full | Proton beam therapy in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus |
| title_fullStr | Proton beam therapy in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus |
| title_full_unstemmed | Proton beam therapy in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus |
| title_short | Proton beam therapy in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus |
| title_sort | proton beam therapy in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus |
| topic | Proton beam therapy Squamous cell carcinoma Nasal cavity Paranasal sinus Multimodal treatment Outcomes |
| url | https://doi.org/10.1186/s13014-023-02296-3 |
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