Mechanobiology-informed biomaterial and tissue engineering strategies for influencing skeletal stem and progenitor cell fate
Skeletal stem and progenitor cells (SSPCs) are the multi-potent, self-renewing cell lineages that form the hematopoietic environment and adventitial structures of the skeletal tissues. Skeletal tissues are responsible for a diverse range of physiological functions because of the extensive differenti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1220555/full |
| _version_ | 1797781007928131584 |
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| author | Seth M. Woodbury Seth M. Woodbury Seth M. Woodbury W. Benton Swanson Yuji Mishina |
| author_facet | Seth M. Woodbury Seth M. Woodbury Seth M. Woodbury W. Benton Swanson Yuji Mishina |
| author_sort | Seth M. Woodbury |
| collection | DOAJ |
| description | Skeletal stem and progenitor cells (SSPCs) are the multi-potent, self-renewing cell lineages that form the hematopoietic environment and adventitial structures of the skeletal tissues. Skeletal tissues are responsible for a diverse range of physiological functions because of the extensive differentiation potential of SSPCs. The differentiation fates of SSPCs are shaped by the physical properties of their surrounding microenvironment and the mechanical loading forces exerted on them within the skeletal system. In this context, the present review first highlights important biomolecules involved with the mechanobiology of how SSPCs sense and transduce these physical signals. The review then shifts focus towards how the static and dynamic physical properties of microenvironments direct the biological fates of SSPCs, specifically within biomaterial and tissue engineering systems. Biomaterial constructs possess designable, quantifiable physical properties that enable the growth of cells in controlled physical environments both in-vitro and in-vivo. The utilization of biomaterials in tissue engineering systems provides a valuable platform for controllably directing the fates of SSPCs with physical signals as a tool for mechanobiology investigations and as a template for guiding skeletal tissue regeneration. It is paramount to study this mechanobiology and account for these mechanics-mediated behaviors to develop next-generation tissue engineering therapies that synergistically combine physical and chemical signals to direct cell fate. Ultimately, taking advantage of the evolved mechanobiology of SSPCs with customizable biomaterial constructs presents a powerful method to predictably guide bone and skeletal organ regeneration. |
| first_indexed | 2024-03-12T23:51:43Z |
| format | Article |
| id | doaj.art-de231791134946f08254d2744cf7db5c |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-12T23:51:43Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-de231791134946f08254d2744cf7db5c2023-07-13T14:28:57ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-07-011410.3389/fphys.2023.12205551220555Mechanobiology-informed biomaterial and tissue engineering strategies for influencing skeletal stem and progenitor cell fateSeth M. Woodbury0Seth M. Woodbury1Seth M. Woodbury2W. Benton Swanson3Yuji Mishina4Yuji Mishina Laboratory, University of Michigan School of Dentistry, Department of Biologic and Materials Science & Prosthodontics, Ann Arbor, MI, United StatesUniversity of Michigan College of Literature, Science, and Arts, Department of Chemistry, Ann Arbor, MI, United StatesUniversity of Michigan College of Literature, Science, and Arts, Department of Physics, Ann Arbor, MI, United StatesYuji Mishina Laboratory, University of Michigan School of Dentistry, Department of Biologic and Materials Science & Prosthodontics, Ann Arbor, MI, United StatesYuji Mishina Laboratory, University of Michigan School of Dentistry, Department of Biologic and Materials Science & Prosthodontics, Ann Arbor, MI, United StatesSkeletal stem and progenitor cells (SSPCs) are the multi-potent, self-renewing cell lineages that form the hematopoietic environment and adventitial structures of the skeletal tissues. Skeletal tissues are responsible for a diverse range of physiological functions because of the extensive differentiation potential of SSPCs. The differentiation fates of SSPCs are shaped by the physical properties of their surrounding microenvironment and the mechanical loading forces exerted on them within the skeletal system. In this context, the present review first highlights important biomolecules involved with the mechanobiology of how SSPCs sense and transduce these physical signals. The review then shifts focus towards how the static and dynamic physical properties of microenvironments direct the biological fates of SSPCs, specifically within biomaterial and tissue engineering systems. Biomaterial constructs possess designable, quantifiable physical properties that enable the growth of cells in controlled physical environments both in-vitro and in-vivo. The utilization of biomaterials in tissue engineering systems provides a valuable platform for controllably directing the fates of SSPCs with physical signals as a tool for mechanobiology investigations and as a template for guiding skeletal tissue regeneration. It is paramount to study this mechanobiology and account for these mechanics-mediated behaviors to develop next-generation tissue engineering therapies that synergistically combine physical and chemical signals to direct cell fate. Ultimately, taking advantage of the evolved mechanobiology of SSPCs with customizable biomaterial constructs presents a powerful method to predictably guide bone and skeletal organ regeneration.https://www.frontiersin.org/articles/10.3389/fphys.2023.1220555/fullmechanobiologybiomaterialstissue engineeringskeletal tissuestem cellprogenitor cell |
| spellingShingle | Seth M. Woodbury Seth M. Woodbury Seth M. Woodbury W. Benton Swanson Yuji Mishina Mechanobiology-informed biomaterial and tissue engineering strategies for influencing skeletal stem and progenitor cell fate Frontiers in Physiology mechanobiology biomaterials tissue engineering skeletal tissue stem cell progenitor cell |
| title | Mechanobiology-informed biomaterial and tissue engineering strategies for influencing skeletal stem and progenitor cell fate |
| title_full | Mechanobiology-informed biomaterial and tissue engineering strategies for influencing skeletal stem and progenitor cell fate |
| title_fullStr | Mechanobiology-informed biomaterial and tissue engineering strategies for influencing skeletal stem and progenitor cell fate |
| title_full_unstemmed | Mechanobiology-informed biomaterial and tissue engineering strategies for influencing skeletal stem and progenitor cell fate |
| title_short | Mechanobiology-informed biomaterial and tissue engineering strategies for influencing skeletal stem and progenitor cell fate |
| title_sort | mechanobiology informed biomaterial and tissue engineering strategies for influencing skeletal stem and progenitor cell fate |
| topic | mechanobiology biomaterials tissue engineering skeletal tissue stem cell progenitor cell |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1220555/full |
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