Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy
Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly reduces lifespan, and its overexpression extends it and protects against various pathological phenotypes, especially renal disease. It was shown to regulate phosphate and calcium metabolism, protect against oxi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/2/956 |
| _version_ | 1797409773062193152 |
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| author | Marlena Typiak Agnieszka Piwkowska |
| author_facet | Marlena Typiak Agnieszka Piwkowska |
| author_sort | Marlena Typiak |
| collection | DOAJ |
| description | Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly reduces lifespan, and its overexpression extends it and protects against various pathological phenotypes, especially renal disease. It was shown to regulate phosphate and calcium metabolism, protect against oxidative stress, downregulate apoptosis, and have antiinflammatory and antifibrotic properties. The course of diabetes mellitus and diabetic nephropathy resembles premature cellular senescence and causes the activation of various proinflammatory and profibrotic processes. Klotho was shown to exert many beneficial effects in these disorders. The expression of Klotho protein is downregulated in early stages of inflammation and diabetic nephropathy by proinflammatory factors. Therefore, its therapeutic effects are diminished in this disorder. Significantly lower urine levels of Klotho may serve as an early biomarker of renal involvement in diabetes mellitus. Recombinant Klotho administration and Klotho overexpression may have immunotherapeutic potential for the treatment of both diabetes and diabetic nephropathy. Therefore, the current manuscript aims to characterize immunopathologies occurring in diabetes and diabetic nephropathy, and tries to match them with antiinflammatory actions of Klotho. It also gives reasons for Klotho to be used in diagnostics and immunotherapy of these disorders. |
| first_indexed | 2024-03-09T04:19:42Z |
| format | Article |
| id | doaj.art-de24d01dd8264ee98b1df67a28531dba |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:19:42Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-de24d01dd8264ee98b1df67a28531dba2023-12-03T13:49:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-0122295610.3390/ijms22020956Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic NephropathyMarlena Typiak0Agnieszka Piwkowska1Laboratory of Molecular and Cellular Nephrology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Wita Stwosza 63, 80-308 Gdansk, PolandLaboratory of Molecular and Cellular Nephrology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Wita Stwosza 63, 80-308 Gdansk, PolandKlotho was initially introduced as an antiaging molecule. Klotho deficiency significantly reduces lifespan, and its overexpression extends it and protects against various pathological phenotypes, especially renal disease. It was shown to regulate phosphate and calcium metabolism, protect against oxidative stress, downregulate apoptosis, and have antiinflammatory and antifibrotic properties. The course of diabetes mellitus and diabetic nephropathy resembles premature cellular senescence and causes the activation of various proinflammatory and profibrotic processes. Klotho was shown to exert many beneficial effects in these disorders. The expression of Klotho protein is downregulated in early stages of inflammation and diabetic nephropathy by proinflammatory factors. Therefore, its therapeutic effects are diminished in this disorder. Significantly lower urine levels of Klotho may serve as an early biomarker of renal involvement in diabetes mellitus. Recombinant Klotho administration and Klotho overexpression may have immunotherapeutic potential for the treatment of both diabetes and diabetic nephropathy. Therefore, the current manuscript aims to characterize immunopathologies occurring in diabetes and diabetic nephropathy, and tries to match them with antiinflammatory actions of Klotho. It also gives reasons for Klotho to be used in diagnostics and immunotherapy of these disorders.https://www.mdpi.com/1422-0067/22/2/956Klotho proteindiabetes mellitusdiabetic nephropathyinflammationdiagnosistherapy |
| spellingShingle | Marlena Typiak Agnieszka Piwkowska Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy International Journal of Molecular Sciences Klotho protein diabetes mellitus diabetic nephropathy inflammation diagnosis therapy |
| title | Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy |
| title_full | Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy |
| title_fullStr | Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy |
| title_full_unstemmed | Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy |
| title_short | Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy |
| title_sort | antiinflammatory actions of klotho implications for therapy of diabetic nephropathy |
| topic | Klotho protein diabetes mellitus diabetic nephropathy inflammation diagnosis therapy |
| url | https://www.mdpi.com/1422-0067/22/2/956 |
| work_keys_str_mv | AT marlenatypiak antiinflammatoryactionsofklothoimplicationsfortherapyofdiabeticnephropathy AT agnieszkapiwkowska antiinflammatoryactionsofklothoimplicationsfortherapyofdiabeticnephropathy |