The C60-Fullerene Porphyrin Adducts for Prevention of the Doxorubicin-Induced Acute Cardiotoxicity in Rat Myocardial Cells
"nThis is a fullerene-based low toxic nanocationite designed for targeted delivery of the paramagnetic stable isotope of magnesium to the doxorubicin (DXR)-induced damaged heart muscle providing a prominent effect close to about 80% recovery of the tissue hypoxia symptoms in less than 24 hr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2010-09-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16940.pdf&manuscript_id=16940 |
| _version_ | 1818555024046817280 |
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| author | Seyed Vahid Shetab Boushehri Seyed Nasser Ostad Saeed Sarkar Dmitry A. Kuznetsov Anatoly L. Buchachenko Marina A. Orlova Bagher Minaii Abbas Kebriaeezadeh Seyed Mahdi Rezayat |
| author_facet | Seyed Vahid Shetab Boushehri Seyed Nasser Ostad Saeed Sarkar Dmitry A. Kuznetsov Anatoly L. Buchachenko Marina A. Orlova Bagher Minaii Abbas Kebriaeezadeh Seyed Mahdi Rezayat |
| author_sort | Seyed Vahid Shetab Boushehri |
| collection | DOAJ |
| description | "nThis is a fullerene-based low toxic nanocationite designed for targeted delivery of the paramagnetic stable isotope of magnesium to the doxorubicin (DXR)-induced damaged heart muscle providing a prominent effect close to about 80% recovery of the tissue hypoxia symptoms in less than 24 hrs after a single injection (0.03 - 0.1 LD50). Magnesium magnetic isotope effect selectively stimulates the ATP formation in the oxygen-depleted cells due to a creatine kinase (CK) and mitochondrial respiratory chain-focusing "attack" of 25Mg2+ released by nanoparticles. These "smart nanoparticles" with membranotropic properties release the overactivating cations only in response to the intracellular acidosis. The resulting positive changes in the energy metabolism of heart cell may help to prevent local myocardial hypoxic (ischemic) disorders and, hence, to protect the heart muscle from a serious damage in a vast variety of the hypoxia-induced clinical situations including DXR side effects. |
| first_indexed | 2024-12-12T09:47:48Z |
| format | Article |
| id | doaj.art-de28a40ea0b1452ab15b56be846dc0a8 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 |
| language | English |
| last_indexed | 2024-12-12T09:47:48Z |
| publishDate | 2010-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-de28a40ea0b1452ab15b56be846dc0a82022-12-22T00:28:21ZengTehran University of Medical SciencesActa Medica Iranica0044-60252010-09-01Vol. 48No. 5342350The C60-Fullerene Porphyrin Adducts for Prevention of the Doxorubicin-Induced Acute Cardiotoxicity in Rat Myocardial CellsSeyed Vahid Shetab BoushehriSeyed Nasser OstadSaeed SarkarDmitry A. KuznetsovAnatoly L. BuchachenkoMarina A. OrlovaBagher MinaiiAbbas KebriaeezadehSeyed Mahdi Rezayat"nThis is a fullerene-based low toxic nanocationite designed for targeted delivery of the paramagnetic stable isotope of magnesium to the doxorubicin (DXR)-induced damaged heart muscle providing a prominent effect close to about 80% recovery of the tissue hypoxia symptoms in less than 24 hrs after a single injection (0.03 - 0.1 LD50). Magnesium magnetic isotope effect selectively stimulates the ATP formation in the oxygen-depleted cells due to a creatine kinase (CK) and mitochondrial respiratory chain-focusing "attack" of 25Mg2+ released by nanoparticles. These "smart nanoparticles" with membranotropic properties release the overactivating cations only in response to the intracellular acidosis. The resulting positive changes in the energy metabolism of heart cell may help to prevent local myocardial hypoxic (ischemic) disorders and, hence, to protect the heart muscle from a serious damage in a vast variety of the hypoxia-induced clinical situations including DXR side effects.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16940.pdf&manuscript_id=16940Fullerene nanoparticlesdoxorubicin-induced cardiotoxicity25Mg2+mitochondrial dysfunctions |
| spellingShingle | Seyed Vahid Shetab Boushehri Seyed Nasser Ostad Saeed Sarkar Dmitry A. Kuznetsov Anatoly L. Buchachenko Marina A. Orlova Bagher Minaii Abbas Kebriaeezadeh Seyed Mahdi Rezayat The C60-Fullerene Porphyrin Adducts for Prevention of the Doxorubicin-Induced Acute Cardiotoxicity in Rat Myocardial Cells Acta Medica Iranica Fullerene nanoparticles doxorubicin-induced cardiotoxicity 25Mg2+ mitochondrial dysfunctions |
| title | The C60-Fullerene Porphyrin Adducts for Prevention of the Doxorubicin-Induced Acute Cardiotoxicity in Rat Myocardial Cells |
| title_full | The C60-Fullerene Porphyrin Adducts for Prevention of the Doxorubicin-Induced Acute Cardiotoxicity in Rat Myocardial Cells |
| title_fullStr | The C60-Fullerene Porphyrin Adducts for Prevention of the Doxorubicin-Induced Acute Cardiotoxicity in Rat Myocardial Cells |
| title_full_unstemmed | The C60-Fullerene Porphyrin Adducts for Prevention of the Doxorubicin-Induced Acute Cardiotoxicity in Rat Myocardial Cells |
| title_short | The C60-Fullerene Porphyrin Adducts for Prevention of the Doxorubicin-Induced Acute Cardiotoxicity in Rat Myocardial Cells |
| title_sort | c60 fullerene porphyrin adducts for prevention of the doxorubicin induced acute cardiotoxicity in rat myocardial cells |
| topic | Fullerene nanoparticles doxorubicin-induced cardiotoxicity 25Mg2+ mitochondrial dysfunctions |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16940.pdf&manuscript_id=16940 |
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