Peripheral Neural Sheath Breast Sarcoma: Case Report and Literature Review
Primary sarcomas of the breast are heterogeneous neoplasms derived from the non-epithelial elements of the mammary gland. Malignant peripheral nerve sheath tumors comprise 5–10% of all malignant soft tissue sarcomas. Its heterogeneity and low incidence (1 in 100,000) limit the performance of prospec...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2022-04-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/523811 |
| _version_ | 1817987236506894336 |
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| author | Yency Johana Forero Martín Ignacio Zapata Laguado Ximena Briceño Ricardo Elías Brugés Fernando Contreras |
| author_facet | Yency Johana Forero Martín Ignacio Zapata Laguado Ximena Briceño Ricardo Elías Brugés Fernando Contreras |
| author_sort | Yency Johana Forero |
| collection | DOAJ |
| description | Primary sarcomas of the breast are heterogeneous neoplasms derived from the non-epithelial elements of the mammary gland. Malignant peripheral nerve sheath tumors comprise 5–10% of all malignant soft tissue sarcomas. Its heterogeneity and low incidence (1 in 100,000) limit the performance of prospective studies. Therefore, most published articles include individual reports and case series with a small number of patients, making it impossible to determine clear treatment standards in this scenario. A 36-year-old young woman with no personal history consulted the National Cancer Institute of Colombia with a 1-year progression of a rapidly growing mass in her left breast until reaching an approximate tumor size of 20 × 20 cm. Histopathological analysis with a tru-cut biopsy taken from the lesion revealed the presence of a breast sarcoma with positive staining for SOX-10 and S-100. A radical mastectomy as her first treatment included the resection of a costal arch and, therefore, the reconstruction of the chest wall with coverage of the defect with an extended latissimus dorsi flap followed by consolidation therapy with adjuvant radiotherapy (RT) and chemotherapy. Evidence regarding malignant peripheral nerve sheath sarcoma of the breast treatment corresponds to retrospective analyses and case reports with high heterogeneity and variability about strategies in surgical procedures and adjunctive therapy such as complementary chemotherapy and RT; therapeutic approach should always include a multidisciplinary team. |
| first_indexed | 2024-04-14T00:18:31Z |
| format | Article |
| id | doaj.art-de28a6ffd0a749e9a5d77d33dbc7f599 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-14T00:18:31Z |
| publishDate | 2022-04-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-de28a6ffd0a749e9a5d77d33dbc7f5992022-12-22T02:23:02ZengKarger PublishersCase Reports in Oncology1662-65752022-04-0115140341210.1159/000523811523811Peripheral Neural Sheath Breast Sarcoma: Case Report and Literature ReviewYency Johana Forero0https://orcid.org/0000-0003-3889-4081Martín Ignacio Zapata Laguado1Ximena Briceño2https://orcid.org/0000-0002-0951-349XRicardo Elías Brugés3https://orcid.org/0000-0002-3649-9515Fernando Contreras4https://orcid.org/0000-0003-1859-5906Clínical Epidemiology, Universidad del Rosario, Bogotá, ColombiaNational Institute of Cancer, Universidad del Bosque, Bogotá, ColombiaNational Institute of Cancer, Fundación Universitaria de Ciencias de la Salud, Bogotá, ColombiaNational Institute of Cancer, Universidad del Bosque, Bogotá, ColombiaNational Institute of Cancer, Universidad del Bosque, Bogotá, ColombiaPrimary sarcomas of the breast are heterogeneous neoplasms derived from the non-epithelial elements of the mammary gland. Malignant peripheral nerve sheath tumors comprise 5–10% of all malignant soft tissue sarcomas. Its heterogeneity and low incidence (1 in 100,000) limit the performance of prospective studies. Therefore, most published articles include individual reports and case series with a small number of patients, making it impossible to determine clear treatment standards in this scenario. A 36-year-old young woman with no personal history consulted the National Cancer Institute of Colombia with a 1-year progression of a rapidly growing mass in her left breast until reaching an approximate tumor size of 20 × 20 cm. Histopathological analysis with a tru-cut biopsy taken from the lesion revealed the presence of a breast sarcoma with positive staining for SOX-10 and S-100. A radical mastectomy as her first treatment included the resection of a costal arch and, therefore, the reconstruction of the chest wall with coverage of the defect with an extended latissimus dorsi flap followed by consolidation therapy with adjuvant radiotherapy (RT) and chemotherapy. Evidence regarding malignant peripheral nerve sheath sarcoma of the breast treatment corresponds to retrospective analyses and case reports with high heterogeneity and variability about strategies in surgical procedures and adjunctive therapy such as complementary chemotherapy and RT; therapeutic approach should always include a multidisciplinary team.https://www.karger.com/Article/FullText/523811soft tissue sarcomaneurofibrosarcomabreast neoplasms |
| spellingShingle | Yency Johana Forero Martín Ignacio Zapata Laguado Ximena Briceño Ricardo Elías Brugés Fernando Contreras Peripheral Neural Sheath Breast Sarcoma: Case Report and Literature Review Case Reports in Oncology soft tissue sarcoma neurofibrosarcoma breast neoplasms |
| title | Peripheral Neural Sheath Breast Sarcoma: Case Report and Literature Review |
| title_full | Peripheral Neural Sheath Breast Sarcoma: Case Report and Literature Review |
| title_fullStr | Peripheral Neural Sheath Breast Sarcoma: Case Report and Literature Review |
| title_full_unstemmed | Peripheral Neural Sheath Breast Sarcoma: Case Report and Literature Review |
| title_short | Peripheral Neural Sheath Breast Sarcoma: Case Report and Literature Review |
| title_sort | peripheral neural sheath breast sarcoma case report and literature review |
| topic | soft tissue sarcoma neurofibrosarcoma breast neoplasms |
| url | https://www.karger.com/Article/FullText/523811 |
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