Functional Hydrogels and Their Applications in Craniomaxillofacial Bone Regeneration
Craniomaxillofacial bone defects are characterized by an irregular shape, bacterial and inflammatory environment, aesthetic requirements, and the need for the functional recovery of oral–maxillofacial areas. Conventional clinical treatments are currently unable to achieve high-quality craniomaxillof...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/1/150 |
| _version_ | 1797437809244504064 |
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| author | Yi Yu Tingting Yu Xing Wang Dawei Liu |
| author_facet | Yi Yu Tingting Yu Xing Wang Dawei Liu |
| author_sort | Yi Yu |
| collection | DOAJ |
| description | Craniomaxillofacial bone defects are characterized by an irregular shape, bacterial and inflammatory environment, aesthetic requirements, and the need for the functional recovery of oral–maxillofacial areas. Conventional clinical treatments are currently unable to achieve high-quality craniomaxillofacial bone regeneration. Hydrogels are a class of multifunctional platforms made of polymers cross-linked with high water content, good biocompatibility, and adjustable physicochemical properties for the intelligent delivery of goods. These characteristics make hydrogel systems a bright prospect for clinical applications in craniomaxillofacial bone. In this review, we briefly demonstrate the properties of hydrogel systems that can come into effect in the field of bone regeneration. In addition, we summarize the hydrogel systems that have been developed for craniomaxillofacial bone regeneration in recent years. Finally, we also discuss the prospects in the field of craniomaxillofacial bone tissue engineering; these discussions can serve as an inspiration for future hydrogel design. |
| first_indexed | 2024-03-09T11:27:59Z |
| format | Article |
| id | doaj.art-de2a06aaa707478bb5e3f6fbd48704b4 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:27:59Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-de2a06aaa707478bb5e3f6fbd48704b42023-11-30T23:58:25ZengMDPI AGPharmaceutics1999-49232022-12-0115115010.3390/pharmaceutics15010150Functional Hydrogels and Their Applications in Craniomaxillofacial Bone RegenerationYi Yu0Tingting Yu1Xing Wang2Dawei Liu3Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, ChinaDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, ChinaBeijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, ChinaCraniomaxillofacial bone defects are characterized by an irregular shape, bacterial and inflammatory environment, aesthetic requirements, and the need for the functional recovery of oral–maxillofacial areas. Conventional clinical treatments are currently unable to achieve high-quality craniomaxillofacial bone regeneration. Hydrogels are a class of multifunctional platforms made of polymers cross-linked with high water content, good biocompatibility, and adjustable physicochemical properties for the intelligent delivery of goods. These characteristics make hydrogel systems a bright prospect for clinical applications in craniomaxillofacial bone. In this review, we briefly demonstrate the properties of hydrogel systems that can come into effect in the field of bone regeneration. In addition, we summarize the hydrogel systems that have been developed for craniomaxillofacial bone regeneration in recent years. Finally, we also discuss the prospects in the field of craniomaxillofacial bone tissue engineering; these discussions can serve as an inspiration for future hydrogel design.https://www.mdpi.com/1999-4923/15/1/150hydrogelcraniomaxillofacial bonebone regenerationstimuli-responsive systemtissue engineeringdelivery system |
| spellingShingle | Yi Yu Tingting Yu Xing Wang Dawei Liu Functional Hydrogels and Their Applications in Craniomaxillofacial Bone Regeneration Pharmaceutics hydrogel craniomaxillofacial bone bone regeneration stimuli-responsive system tissue engineering delivery system |
| title | Functional Hydrogels and Their Applications in Craniomaxillofacial Bone Regeneration |
| title_full | Functional Hydrogels and Their Applications in Craniomaxillofacial Bone Regeneration |
| title_fullStr | Functional Hydrogels and Their Applications in Craniomaxillofacial Bone Regeneration |
| title_full_unstemmed | Functional Hydrogels and Their Applications in Craniomaxillofacial Bone Regeneration |
| title_short | Functional Hydrogels and Their Applications in Craniomaxillofacial Bone Regeneration |
| title_sort | functional hydrogels and their applications in craniomaxillofacial bone regeneration |
| topic | hydrogel craniomaxillofacial bone bone regeneration stimuli-responsive system tissue engineering delivery system |
| url | https://www.mdpi.com/1999-4923/15/1/150 |
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