A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing
Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads to drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired. Herein, we reported a composite...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2022-09-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21005806 |
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| author | Zhaoyuan Guo Zhuangzhuang Zhang Nan Zhang Wenxia Gao Jing Li Yuji Pu Bin He Jing Xie |
| author_facet | Zhaoyuan Guo Zhuangzhuang Zhang Nan Zhang Wenxia Gao Jing Li Yuji Pu Bin He Jing Xie |
| author_sort | Zhaoyuan Guo |
| collection | DOAJ |
| description | Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads to drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired. Herein, we reported a composite antibacterial hydrogel PDA-PAM/Mg2+ that shows excellent self-healing and tissue adhesive property, and photothermal antibacterial functions for accelerating wound healing. The gel was composed of polyacrylamide (PAM), polydopamine (PDA), and magnesium (Mg2+) and prepared via a two-step procedure: an alkali-induced dopamine pre-polymerization and followed radical polymerization process. The composite gel shows excellent tissue adhesiveness and Mg2+-synergized photothermal antibacterial activity, inducing a survival rate of 5.29% for S. aureus and 7.06% for E. coli after near infrared light irradiation. The composite hydrogel further demonstrated efficient bacteria inhibition, enhanced wound healing and collagen deposition in a full-thickness skin defect rat model. Together, the PDA-PAM/Mg2+ hydrogel presents an excellent wound dressing with excellent tissue adhesion, wound healing, and antibacterial functions. |
| first_indexed | 2024-04-24T08:17:38Z |
| format | Article |
| id | doaj.art-de2ad020f6564990896474ae19ff0e80 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:17:38Z |
| publishDate | 2022-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-de2ad020f6564990896474ae19ff0e802024-04-17T03:21:03ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-09-0115203213A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healingZhaoyuan Guo0Zhuangzhuang Zhang1Nan Zhang2Wenxia Gao3Jing Li4Yuji Pu5Bin He6Jing Xie7College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, China; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610065, ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610065, ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610065, ChinaCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, China; Corresponding author.National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610065, ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610065, ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610065, China; Corresponding author.Department of Stomatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China; Corresponding author.Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads to drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired. Herein, we reported a composite antibacterial hydrogel PDA-PAM/Mg2+ that shows excellent self-healing and tissue adhesive property, and photothermal antibacterial functions for accelerating wound healing. The gel was composed of polyacrylamide (PAM), polydopamine (PDA), and magnesium (Mg2+) and prepared via a two-step procedure: an alkali-induced dopamine pre-polymerization and followed radical polymerization process. The composite gel shows excellent tissue adhesiveness and Mg2+-synergized photothermal antibacterial activity, inducing a survival rate of 5.29% for S. aureus and 7.06% for E. coli after near infrared light irradiation. The composite hydrogel further demonstrated efficient bacteria inhibition, enhanced wound healing and collagen deposition in a full-thickness skin defect rat model. Together, the PDA-PAM/Mg2+ hydrogel presents an excellent wound dressing with excellent tissue adhesion, wound healing, and antibacterial functions.http://www.sciencedirect.com/science/article/pii/S2452199X21005806Multifunctional hydrogelSelf-healingTissue adhesivenessPhotothermal antibacterial effectWound healing |
| spellingShingle | Zhaoyuan Guo Zhuangzhuang Zhang Nan Zhang Wenxia Gao Jing Li Yuji Pu Bin He Jing Xie A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing Bioactive Materials Multifunctional hydrogel Self-healing Tissue adhesiveness Photothermal antibacterial effect Wound healing |
| title | A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing |
| title_full | A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing |
| title_fullStr | A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing |
| title_full_unstemmed | A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing |
| title_short | A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing |
| title_sort | mg2 polydopamine composite hydrogel for the acceleration of infected wound healing |
| topic | Multifunctional hydrogel Self-healing Tissue adhesiveness Photothermal antibacterial effect Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X21005806 |
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