Molecular Mechanisms and Cellular Contribution from Lung Fibrosis to Lung Cancer Development

Molecular Mechanisms and Cellular Contribution from Lung Fibrosis to Lung Cancer Development

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease (ILD) of unknown aetiology, with a median survival of 2–4 years from the time of diagnosis. Although IPF has unknown aetiology by definition, there have been identified several risks factors increasing...

Full description

Bibliographic Details
Main Authors:	Anna Valeria Samarelli, Valentina Masciale, Beatrice Aramini, Georgina Pamela Coló, Roberto Tonelli, Alessandro Marchioni, Giulia Bruzzi, Filippo Gozzi, Dario Andrisani, Ivana Castaniere, Linda Manicardi, Antonio Moretti, Luca Tabbì, Giorgia Guaitoli, Stefania Cerri, Massimo Dominici, Enrico Clini
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Series:	International Journal of Molecular Sciences
Subjects:	idiopathic pulmonary fibrosis lung cancer myofibroblast cancer associated fibroblasts (CAFs) mechanotrasduction
Online Access:	https://www.mdpi.com/1422-0067/22/22/12179

Similar Items

Fibrotic Idiopathic Interstitial Lung Disease: The Molecular and Cellular Key Players
by: Anna Valeria Samarelli, et al.
Published: (2021-08-01)

Proteomic profiling of formalin-fixed paraffine-embedded tissue reveals key proteins related to lung dysfunction in idiopathic pulmonary fibrosis
by: Anna Valeria Samarelli, et al.
Published: (2024-01-01)

Biological effects of COVID-19 on lung cancer: Can we drive our decisions
by: Beatrice Aramini, et al.
Published: (2022-10-01)

Pulmonary Stretch and Lung Mechanotransduction: Implications for Progression in the Fibrotic Lung
by: Alessandro Marchioni, et al.
Published: (2021-06-01)

A High-Throughput System for Cyclic Stretching of Precision-Cut Lung Slices During Acute Cigarette Smoke Extract Exposure
by: Jarred R. Mondoñedo, et al.
Published: (2020-06-01)

Dissecting the Role of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis: Cause or Solution
by: Anna Valeria Samarelli, et al.
Published: (2021-07-01)

Cancer Stem Cells (CSCs), Circulating Tumor Cells (CTCs) and Their Interplay with Cancer Associated Fibroblasts (CAFs): A New World of Targets and Treatments
by: Beatrice Aramini, et al.
Published: (2022-05-01)

Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario
by: Roberto Tonelli, et al.
Published: (2021-03-01)

Cancer Stem-Like Cells in a Case of an Inflammatory Myofibroblastic Tumor of the Lung
by: Valentina Masciale, et al.
Published: (2020-05-01)

Cancer-Associated Fibroblast Heterogeneity and Its Influence on the Extracellular Matrix and the Tumor Microenvironment
by: Karl Knipper, et al.
Published: (2023-08-01)

Identification of Prognostic Biomarkers Originating From the Tumor Stroma of Betel Quid-Associated Oral Cancer Tissues
by: Yi-Hong Liu, et al.
Published: (2021-11-01)

A Bioreactor for 3D In Vitro Modeling of the Mechanical Stimulation of Osteocytes
by: Koh Meng Aw Yong, et al.
Published: (2022-03-01)

Editorial: Pulmonary fibrosis and lung carcinogenesis: do myofibroblasts and cancer-associated fibroblasts share a common identity?
by: Daniela de Totero, et al.
Published: (2024-03-01)

Hematopoietic Transcription Factor RUNX1 is Essential for Promoting Macrophage–Myofibroblast Transition in Non‐Small‐Cell Lung Carcinoma
by: Philip Chiu‐Tsun Tang, et al.
Published: (2024-01-01)

Cancer-Associated Fibroblast Density, Prognostic Characteristics, and Recurrence in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis
by: Alexander M. Knops, et al.
Published: (2020-11-01)

The Review of Bioeffects of Static Magnetic Fields on the Oral Tissue-Derived Cells and Its Application in Regenerative Medicine
by: Wei-Zhen Lew, et al.
Published: (2021-10-01)

Tenascin-C and mechanotransduction in the development and diseases of cardiovascular system.
by: Kyoko eImanaka-Yoshida, et al.
Published: (2014-07-01)

An Overview of the Role of Mechanical Stretching in the Progression of Lung Cancer
by: Fengying Gong, et al.
Published: (2021-12-01)

The Heterogeneity of the Tumor Microenvironment as Essential Determinant of Development, Progression and Therapy Response of Pancreatic Cancer
by: Group Young Researchers in Inflammatory Carcinogenesis, et al.
Published: (2021-09-01)

Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma: An Update on Heterogeneity and Therapeutic Targeting
by: Utpreksha Vaish, et al.
Published: (2021-12-01)

Deciphering the temporal heterogeneity of cancer-associated fibroblast subpopulations in breast cancer
by: Freja Albjerg Venning, et al.
Published: (2021-05-01)

Deepening the Knowledge of <i>ROS1</i> Rearrangements in Non-Small Cell Lung Cancer: Diagnosis, Treatment, Resistance and Concomitant Alterations
by: Giorgia Guaitoli, et al.
Published: (2021-11-01)

The Blockade of Tumoral IL1β-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation
by: Natalia Guillén Díaz-Maroto, et al.
Published: (2021-05-01)

Glutathione peroxidase 8 expression on cancer cells and cancer‐associated fibroblasts facilitates lung cancer metastasis
by: Yu‐Lian Xu, et al.
Published: (2022-09-01)

Transcription factors in fibroblast plasticity and CAF heterogeneity
by: Roberta Melchionna, et al.
Published: (2023-12-01)

Morphological Characterization of Human Lung Cancer Organoids Cultured in Type I Collagen Hydrogels: A Histological Approach
by: Irene Monleón-Guinot, et al.
Published: (2023-06-01)

Rare inflammatory myofibroblastic lung tumor with multi-organ metastasis: A case report
by: Marina D. Budurova, et al.
Published: (2023-12-01)

Molecular Mechanisms and Physiological Changes behind Benign Tracheal and Subglottic Stenosis in Adults
by: Alessandro Marchioni, et al.
Published: (2022-02-01)

Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer
by: Mikkel Morsing Bagger, et al.
Published: (2024-01-01)

Dissecting the functions of cancer-associated fibroblasts to therapeutically target head and neck cancer microenvironment
by: Llara Prieto-Fernández, et al.
Published: (2023-05-01)

Prognostic Significance of Stromal Periostin Expression in Non-Small Cell Lung Cancer
by: Katarzyna Ratajczak-Wielgomas, et al.
Published: (2020-09-01)

Crosstalk between Tumor and Stromal Cells in Pancreatic Ductal Adenocarcinoma
by: Nadine Sperb, et al.
Published: (2020-07-01)

Dissecting Tumor Growth: The Role of Cancer Stem Cells in Drug Resistance and Recurrence
by: Beatrice Aramini, et al.
Published: (2022-02-01)

Obstructive sleep apnea promotes the progression of lung cancer by modulating cancer cell invasion and cancer-associated fibroblast activation via TGFβ signaling
by: Zhilei Cui, et al.
Published: (2023-12-01)

Editorial: Crosstalk between cancer-associated fibroblasts and tumor cells in the tumor microenvironment: an emerging target of anti-cancer immunotherapy
by: Chunxue Zhang, et al.
Published: (2023-08-01)

Phenotypic, functional, and metabolic heterogeneity of immune cells infiltrating non–small cell lung cancer
by: Beatrice Aramini, et al.
Published: (2022-08-01)

Reassessing Breast Cancer-Associated Fibroblasts (CAFs) Interactions with Other Stromal Components and Clinico-Pathologic Parameters by Using Immunohistochemistry and Digital Image Analysis (DIA)
by: Alina Cristina Barb, et al.
Published: (2023-07-01)

Identification and characterization of FGFR2+ hematopoietic stem cell-derived fibrocytes as precursors of cancer-associated fibroblasts induced by esophageal squamous cell carcinoma
by: Haibo Qiu, et al.
Published: (2022-08-01)

The cancer-associated fibroblast-related signature predicts prognosis and indicates immune microenvironment infiltration in gastric cancer
by: Tsz Kin Mak, et al.
Published: (2022-07-01)

Characterization and Clinical Relevance of Endometrial CAFs: Correlation between Post-Surgery Event and Resistance to Drugs
by: Raed Sulaiman, et al.
Published: (2023-03-01)