Abdominal tissue concentrations and penetration of carboplatin in a HIPEC procedure ‒ assessment in a novel porcine model
Peritoneal dissemination from intraabdominal cancers is associated with poor prognosis and rapid disease progression. Hyperthermic intraperitoneal chemotherapy (HIPEC) is an antineoplastic treatment, which has improved survival and recurrence-free survival, but little is known about the acquired che...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-06-01
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| Series: | Pleura and Peritoneum |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pp-2022-0110 |
| _version_ | 1818027235567730688 |
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| author | Petersen Elisabeth K. Bue Mats Harlev Christina Jørgensen Andrea R. Schmedes Anne Hanberg Pelle Petersen Lone K. Stilling Maiken |
| author_facet | Petersen Elisabeth K. Bue Mats Harlev Christina Jørgensen Andrea R. Schmedes Anne Hanberg Pelle Petersen Lone K. Stilling Maiken |
| author_sort | Petersen Elisabeth K. |
| collection | DOAJ |
| description | Peritoneal dissemination from intraabdominal cancers is associated with poor prognosis and rapid disease progression. Hyperthermic intraperitoneal chemotherapy (HIPEC) is an antineoplastic treatment, which has improved survival and recurrence-free survival, but little is known about the acquired chemotherapy concentrations in local tissues. The aim of this study was to assess concentrations of carboplatin during and after HIPEC treatment dynamically and simultaneously in various abdominal organ tissues by means of microdialysis in a novel porcine model. |
| first_indexed | 2024-12-10T04:44:41Z |
| format | Article |
| id | doaj.art-de2d1955068349d8a662123a3e6b9b52 |
| institution | Directory Open Access Journal |
| issn | 2364-768X |
| language | English |
| last_indexed | 2024-12-10T04:44:41Z |
| publishDate | 2022-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pleura and Peritoneum |
| spelling | doaj.art-de2d1955068349d8a662123a3e6b9b522022-12-22T02:01:46ZengDe GruyterPleura and Peritoneum2364-768X2022-06-017311712510.1515/pp-2022-0110Abdominal tissue concentrations and penetration of carboplatin in a HIPEC procedure ‒ assessment in a novel porcine modelPetersen Elisabeth K.0Bue Mats1Harlev Christina2Jørgensen Andrea R.3Schmedes Anne4Hanberg Pelle5Petersen Lone K.6Stilling Maiken7Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, DenmarkDepartment of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, DenmarkDepartment of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, DenmarkDepartment of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, DenmarkDepartment of Biochemistry and Immunology, Lillebaelt Hospital, Vejle, DenmarkDepartment of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, DenmarkDepartment of Gynaecology and Obstetrics, Odense University Hospital and Department of Clinical Medicine, University of Southern Denmark, Odense, DenmarkDepartment of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, DenmarkPeritoneal dissemination from intraabdominal cancers is associated with poor prognosis and rapid disease progression. Hyperthermic intraperitoneal chemotherapy (HIPEC) is an antineoplastic treatment, which has improved survival and recurrence-free survival, but little is known about the acquired chemotherapy concentrations in local tissues. The aim of this study was to assess concentrations of carboplatin during and after HIPEC treatment dynamically and simultaneously in various abdominal organ tissues by means of microdialysis in a novel porcine model.https://doi.org/10.1515/pp-2022-0110carboplatinhyperthermic intraperitoneal chemotherapymicrodialysispharmacokinetics |
| spellingShingle | Petersen Elisabeth K. Bue Mats Harlev Christina Jørgensen Andrea R. Schmedes Anne Hanberg Pelle Petersen Lone K. Stilling Maiken Abdominal tissue concentrations and penetration of carboplatin in a HIPEC procedure ‒ assessment in a novel porcine model Pleura and Peritoneum carboplatin hyperthermic intraperitoneal chemotherapy microdialysis pharmacokinetics |
| title | Abdominal tissue concentrations and penetration of carboplatin in a HIPEC procedure ‒ assessment in a novel porcine model |
| title_full | Abdominal tissue concentrations and penetration of carboplatin in a HIPEC procedure ‒ assessment in a novel porcine model |
| title_fullStr | Abdominal tissue concentrations and penetration of carboplatin in a HIPEC procedure ‒ assessment in a novel porcine model |
| title_full_unstemmed | Abdominal tissue concentrations and penetration of carboplatin in a HIPEC procedure ‒ assessment in a novel porcine model |
| title_short | Abdominal tissue concentrations and penetration of carboplatin in a HIPEC procedure ‒ assessment in a novel porcine model |
| title_sort | abdominal tissue concentrations and penetration of carboplatin in a hipec procedure assessment in a novel porcine model |
| topic | carboplatin hyperthermic intraperitoneal chemotherapy microdialysis pharmacokinetics |
| url | https://doi.org/10.1515/pp-2022-0110 |
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