Dietary α-Linolenic Acid-Rich Flaxseed Oil Ameliorates High-Fat Diet-Induced Atherosclerosis via Gut Microbiota-Inflammation-Artery Axis in ApoE−/− Mice

Dietary α-Linolenic Acid-Rich Flaxseed Oil Ameliorates High-Fat Diet-Induced Atherosclerosis via Gut Microbiota-Inflammation-Artery Axis in ApoE−/− Mice

Atherosclerosis (AS) is closely associated with abnormally chronic low-grade inflammation and gut dysbiosis. Flaxseed oil (FO) rich in omega-3 polyunsaturated fatty acids (PUFAs), which are mainly composed of alpha-linolenic acid (ALA, 18:3 omega-3), has been demonstrated to exhibit pleiotropic bene...

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Bibliographic Details
Main Authors: Yiwei Li, Zhi Yu, Yuanyuan Liu, Ting Wang, Yajuan Liu, Zhixia Bai, Yi Ren, Huiyan Ma, Ting Bao, Haixia Lu, Rui Wang, Libo Yang, Ning Yan, Ru Yan, Shaobin Jia, Xiaoxia Zhang, Hao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
ALA-rich flaxseed oil
atherosclerosis
inflammation
gut microbiota
intestinal metabolites
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.830781/full

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