Proline metabolism reprogramming of trained macrophages induced by early respiratory infection combined with allergen sensitization contributes to development of allergic asthma in childhood of mice

Proline metabolism reprogramming of trained macrophages induced by early respiratory infection combined with allergen sensitization contributes to development of allergic asthma in childhood of mice

BackgroundInfants with respiratory syncytial virus (RSV)-associated bronchiolitis are at increased risk of childhood asthma. Recent studies demonstrated that certain infections induce innate immune memory (also termed trained immunity), especially in macrophages, to respond more strongly to future s...

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Bibliographic Details
Main Authors: Hanglin Li, Linyan Ma, Wenjian Li, Boyang Zheng, Junhai Wang, Shunyan Chen, Yang Wang, Fei Ge, Beibei Qin, Xiaoqing Zheng, Yuqing Deng, Ruihong Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
allergic asthma
trained macrophages
innate immune memory
proline metabolism reprogramming
respiratory virus infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.977235/full

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