Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol
Abstract We report the case of a 42‐year‐old female with a history of finger clubbing which improved during pregnancy, a history of unexplained hepatosplenomegaly, and subsequent non‐specific interstitial pneumonia with respiratory failure. Given a personal and family history of early greying of the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-08-01
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| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.607 |
| _version_ | 1818498112215318528 |
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| author | Daniel C. Chambers Viviana P. Lutzky Simon H. Apte David Godbolt John Feenstra John Mackintosh |
| author_facet | Daniel C. Chambers Viviana P. Lutzky Simon H. Apte David Godbolt John Feenstra John Mackintosh |
| author_sort | Daniel C. Chambers |
| collection | DOAJ |
| description | Abstract We report the case of a 42‐year‐old female with a history of finger clubbing which improved during pregnancy, a history of unexplained hepatosplenomegaly, and subsequent non‐specific interstitial pneumonia with respiratory failure. Given a personal and family history of early greying of the hair, the peripheral blood monocyte telomere length was measured and was confirmed to be <1st centile, explaining the multiorgan presentation. She was treated with prednisolone, mycophenolate mofetil, and the synthetic androgen danazol with a dramatic improvement in respiratory failure and lung function. After 18 months of danazol treatment, the peripheral blood monocyte telomere length had returned to the normal range. |
| first_indexed | 2024-12-10T18:53:54Z |
| format | Article |
| id | doaj.art-de32198dd45d4bceb2712d1a1cba2d9f |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-12-10T18:53:54Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-de32198dd45d4bceb2712d1a1cba2d9f2022-12-22T01:37:13ZengWileyRespirology Case Reports2051-33802020-08-0186n/an/a10.1002/rcr2.607Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazolDaniel C. Chambers0Viviana P. Lutzky1Simon H. Apte2David Godbolt3John Feenstra4John Mackintosh5Qld Lung Transplant Service The Prince Charles Hospital Brisbane QLD AustraliaQld Lung Transplant Service The Prince Charles Hospital Brisbane QLD AustraliaQld Lung Transplant Service The Prince Charles Hospital Brisbane QLD AustraliaDepartment of Pathology The Prince Charles Hospital Brisbane QLD AustraliaQld Lung Transplant Service The Prince Charles Hospital Brisbane QLD AustraliaQld Lung Transplant Service The Prince Charles Hospital Brisbane QLD AustraliaAbstract We report the case of a 42‐year‐old female with a history of finger clubbing which improved during pregnancy, a history of unexplained hepatosplenomegaly, and subsequent non‐specific interstitial pneumonia with respiratory failure. Given a personal and family history of early greying of the hair, the peripheral blood monocyte telomere length was measured and was confirmed to be <1st centile, explaining the multiorgan presentation. She was treated with prednisolone, mycophenolate mofetil, and the synthetic androgen danazol with a dramatic improvement in respiratory failure and lung function. After 18 months of danazol treatment, the peripheral blood monocyte telomere length had returned to the normal range.https://doi.org/10.1002/rcr2.607Danazolinterstitial lung diseasenon‐specific interstitial pneumoniatelomere |
| spellingShingle | Daniel C. Chambers Viviana P. Lutzky Simon H. Apte David Godbolt John Feenstra John Mackintosh Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol Respirology Case Reports Danazol interstitial lung disease non‐specific interstitial pneumonia telomere |
| title | Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol |
| title_full | Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol |
| title_fullStr | Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol |
| title_full_unstemmed | Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol |
| title_short | Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol |
| title_sort | successful treatment of telomeropathy related interstitial lung disease with immunosuppression and danazol |
| topic | Danazol interstitial lung disease non‐specific interstitial pneumonia telomere |
| url | https://doi.org/10.1002/rcr2.607 |
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