Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project
Background . The Aklavik H. pylori Project (AHPP) (www.canhelpworkinggroup.ca) is a community-driven project examining Helicobacter pylori infection and its influence on health in a diverse Aboriginal community in the Northwest Territories. Initial research revealed that 58% of 333 participants who...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2013-08-01
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| Series: | International Journal of Circumpolar Health |
| Subjects: | |
| Online Access: | http://www.circumpolarhealthjournal.net/index.php/ijch/article/download/21594/pdf_1 |
| _version_ | 1819041754573176832 |
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| author | Sally Carraher Hsiu-Ju Chang Rachel Munday Karen J. Goodman the CANHelp Working Group |
| author_facet | Sally Carraher Hsiu-Ju Chang Rachel Munday Karen J. Goodman the CANHelp Working Group |
| author_sort | Sally Carraher |
| collection | DOAJ |
| description | Background . The Aklavik H. pylori Project (AHPP) (www.canhelpworkinggroup.ca) is a community-driven project examining Helicobacter pylori infection and its influence on health in a diverse Aboriginal community in the Northwest Territories. Initial research revealed that 58% of 333 participants who underwent a urea breath test (UBT) between 2007 and 2010 were H. pylori-positive. From 2008 to 2010, we offered treatment to H. pylori-positive participants and 113 consented to this treatment. Objective . We estimated H. pylori incidence in AHPP participants who initially tested negative and the re-infection frequency in initially positive participants who were successfully treated to clear the infection. Methods . Participants who were initially H. pylori-negative or negative after treatment during 2008–2010 were eligible for inclusion. From November 2011 to June 2012, participants were offered a UBT and the samples were analyzed using infrared spectroscopy (IRIS). Participants with a positive test result were classified as new cases for estimating incidence among participants testing negative at baseline and re-infection among those successfully treated for H. pylori infection. Results. Among 38 initially negative participants, follow-up UBT showed that 33 remained negative, 3 were positive, and 2 had uncertain status. The estimated incidence proportion during the follow-up period was 8.3% (95% CI: 1.8–22.0%). Among 43 participants with a negative post-treatment UBT, 41 remained negative and 2 were positive. The estimated re-infection proportion during the follow-up period was 4.7% (95% CI: 0.6–16.0%). The frequency of new cases was similar in males and females. Aboriginal participants had a combined re-infection/incidence rate of 2.4% per year (95% CI: 0.8–5.9% per year). All 9 non-Aboriginal participants remained free from infection throughout the study period, as did all 23 participants aged 55 years and above. Conclusions . The AHPP has substantially reduced the burden of infection in Aklavik since 2008. Continued monitoring, treatment, community engagement and knowledge translation activities are needed to ensure a lasting benefit of the project. |
| first_indexed | 2024-12-21T09:30:01Z |
| format | Article |
| id | doaj.art-de33a2cfd4374bd5a6634b73a7cf9927 |
| institution | Directory Open Access Journal |
| issn | 2242-3982 |
| language | English |
| last_indexed | 2024-12-21T09:30:01Z |
| publishDate | 2013-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Circumpolar Health |
| spelling | doaj.art-de33a2cfd4374bd5a6634b73a7cf99272022-12-21T19:08:48ZengTaylor & Francis GroupInternational Journal of Circumpolar Health2242-39822013-08-017201710.3402/ijch.v72i0.21594Helicobacter pylori incidence and re-infection in the Aklavik H. pylori ProjectSally CarraherHsiu-Ju ChangRachel MundayKaren J. Goodmanthe CANHelp Working GroupBackground . The Aklavik H. pylori Project (AHPP) (www.canhelpworkinggroup.ca) is a community-driven project examining Helicobacter pylori infection and its influence on health in a diverse Aboriginal community in the Northwest Territories. Initial research revealed that 58% of 333 participants who underwent a urea breath test (UBT) between 2007 and 2010 were H. pylori-positive. From 2008 to 2010, we offered treatment to H. pylori-positive participants and 113 consented to this treatment. Objective . We estimated H. pylori incidence in AHPP participants who initially tested negative and the re-infection frequency in initially positive participants who were successfully treated to clear the infection. Methods . Participants who were initially H. pylori-negative or negative after treatment during 2008–2010 were eligible for inclusion. From November 2011 to June 2012, participants were offered a UBT and the samples were analyzed using infrared spectroscopy (IRIS). Participants with a positive test result were classified as new cases for estimating incidence among participants testing negative at baseline and re-infection among those successfully treated for H. pylori infection. Results. Among 38 initially negative participants, follow-up UBT showed that 33 remained negative, 3 were positive, and 2 had uncertain status. The estimated incidence proportion during the follow-up period was 8.3% (95% CI: 1.8–22.0%). Among 43 participants with a negative post-treatment UBT, 41 remained negative and 2 were positive. The estimated re-infection proportion during the follow-up period was 4.7% (95% CI: 0.6–16.0%). The frequency of new cases was similar in males and females. Aboriginal participants had a combined re-infection/incidence rate of 2.4% per year (95% CI: 0.8–5.9% per year). All 9 non-Aboriginal participants remained free from infection throughout the study period, as did all 23 participants aged 55 years and above. Conclusions . The AHPP has substantially reduced the burden of infection in Aklavik since 2008. Continued monitoring, treatment, community engagement and knowledge translation activities are needed to ensure a lasting benefit of the project.http://www.circumpolarhealthjournal.net/index.php/ijch/article/download/21594/pdf_1Helicobacter pylori infectionAboriginal healthcollaborative researchepidemiologyincidenceArctic |
| spellingShingle | Sally Carraher Hsiu-Ju Chang Rachel Munday Karen J. Goodman the CANHelp Working Group Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project International Journal of Circumpolar Health Helicobacter pylori infection Aboriginal health collaborative research epidemiology incidence Arctic |
| title | Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project |
| title_full | Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project |
| title_fullStr | Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project |
| title_full_unstemmed | Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project |
| title_short | Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project |
| title_sort | helicobacter pylori incidence and re infection in the aklavik h pylori project |
| topic | Helicobacter pylori infection Aboriginal health collaborative research epidemiology incidence Arctic |
| url | http://www.circumpolarhealthjournal.net/index.php/ijch/article/download/21594/pdf_1 |
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