Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation
Mechanical force is critical for the development and remodeling of bones. Here the authors report that mechanical force regulates the production of the metabolite asymmetric dimethylarginine via regulating the expression of the hydrolytic enzyme dimethylarginine dimethylaminohydrolase 1 in osteoblas...
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Bibliographic Details
| Main Authors: |
Ziang Xie,
Lei Hou,
Shuying Shen,
Yizheng Wu,
Jian Wang,
Zhiwei Jie,
Xiangde Zhao,
Xiang Li,
Xuyang Zhang,
Junxin Chen,
Wenbin Xu,
Lei Ning,
Qingliang Ma,
Shiyu Wang,
Haoming Wang,
Putao Yuan,
Xiangqian Fang,
An Qin,
Shunwu Fan |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-27629-2
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