Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation
Mechanical force is critical for the development and remodeling of bones. Here the authors report that mechanical force regulates the production of the metabolite asymmetric dimethylarginine via regulating the expression of the hydrolytic enzyme dimethylarginine dimethylaminohydrolase 1 in osteoblas...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27629-2 |
| _version_ | 1819006778426261504 |
|---|---|
| author | Ziang Xie Lei Hou Shuying Shen Yizheng Wu Jian Wang Zhiwei Jie Xiangde Zhao Xiang Li Xuyang Zhang Junxin Chen Wenbin Xu Lei Ning Qingliang Ma Shiyu Wang Haoming Wang Putao Yuan Xiangqian Fang An Qin Shunwu Fan |
| author_facet | Ziang Xie Lei Hou Shuying Shen Yizheng Wu Jian Wang Zhiwei Jie Xiangde Zhao Xiang Li Xuyang Zhang Junxin Chen Wenbin Xu Lei Ning Qingliang Ma Shiyu Wang Haoming Wang Putao Yuan Xiangqian Fang An Qin Shunwu Fan |
| author_sort | Ziang Xie |
| collection | DOAJ |
| description | Mechanical force is critical for the development and remodeling of bones. Here the authors report that mechanical force regulates the production of the metabolite asymmetric dimethylarginine via regulating the expression of the hydrolytic enzyme dimethylarginine dimethylaminohydrolase 1 in osteoblasts. |
| first_indexed | 2024-12-21T00:14:05Z |
| format | Article |
| id | doaj.art-de35a50f762c45b28e46ba6913cdceeb |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T00:14:05Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-de35a50f762c45b28e46ba6913cdceeb2022-12-21T19:22:17ZengNature PortfolioNature Communications2041-17232022-01-0113111510.1038/s41467-021-27629-2Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formationZiang Xie0Lei Hou1Shuying Shen2Yizheng Wu3Jian Wang4Zhiwei Jie5Xiangde Zhao6Xiang Li7Xuyang Zhang8Junxin Chen9Wenbin Xu10Lei Ning11Qingliang Ma12Shiyu Wang13Haoming Wang14Putao Yuan15Xiangqian Fang16An Qin17Shunwu Fan18Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Cardiology, Shanghai Tongren Hospital, Shanghai Jiaotong University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopaedics, Tongde Hospital of Zhejiang ProvinceDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of MedicineDepartment of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineMechanical force is critical for the development and remodeling of bones. Here the authors report that mechanical force regulates the production of the metabolite asymmetric dimethylarginine via regulating the expression of the hydrolytic enzyme dimethylarginine dimethylaminohydrolase 1 in osteoblasts.https://doi.org/10.1038/s41467-021-27629-2 |
| spellingShingle | Ziang Xie Lei Hou Shuying Shen Yizheng Wu Jian Wang Zhiwei Jie Xiangde Zhao Xiang Li Xuyang Zhang Junxin Chen Wenbin Xu Lei Ning Qingliang Ma Shiyu Wang Haoming Wang Putao Yuan Xiangqian Fang An Qin Shunwu Fan Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation Nature Communications |
| title | Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation |
| title_full | Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation |
| title_fullStr | Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation |
| title_full_unstemmed | Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation |
| title_short | Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation |
| title_sort | mechanical force promotes dimethylarginine dimethylaminohydrolase 1 mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation |
| url | https://doi.org/10.1038/s41467-021-27629-2 |
| work_keys_str_mv | AT ziangxie mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT leihou mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT shuyingshen mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT yizhengwu mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT jianwang mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT zhiweijie mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT xiangdezhao mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT xiangli mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT xuyangzhang mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT junxinchen mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT wenbinxu mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT leining mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT qingliangma mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT shiyuwang mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT haomingwang mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT putaoyuan mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT xiangqianfang mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT anqin mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation AT shunwufan mechanicalforcepromotesdimethylargininedimethylaminohydrolase1mediatedhydrolysisofthemetaboliteasymmetricdimethylargininetoenhanceboneformation |