Prolonged lipopolysaccharide‐induced illness elevates glucagon‐like peptide‐1 and suppresses peptide YY: A human‐randomized cross‐over trial
Abstract Severe systemic inflammation is associated with nausea, loss of appetite, and delayed gastric emptying, which increases hospitalization admission length and mortality rate. There is a lack of human controlled studies exploring gastric emptying rates and underlying mechanisms during inflamma...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.15462 |
| _version_ | 1811204277986656256 |
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| author | Katrine Brodersen Maike Mose Ulla Ramer Mikkelsen Jens Otto Lunde Jørgensen Michael Festersen Nielsen Niels Møller Anne‐Marie Wegeberg Christina Brock Bolette Hartmann Jens Juul Holst Nikolaj Rittig |
| author_facet | Katrine Brodersen Maike Mose Ulla Ramer Mikkelsen Jens Otto Lunde Jørgensen Michael Festersen Nielsen Niels Møller Anne‐Marie Wegeberg Christina Brock Bolette Hartmann Jens Juul Holst Nikolaj Rittig |
| author_sort | Katrine Brodersen |
| collection | DOAJ |
| description | Abstract Severe systemic inflammation is associated with nausea, loss of appetite, and delayed gastric emptying, which increases hospitalization admission length and mortality rate. There is a lack of human controlled studies exploring gastric emptying rates and underlying mechanisms during inflammatory conditions. We aimed to investigate if systemic inflammation in young men delays gastro‐intestinal transit times, lowers motility, and affects gastrointestinal hormone secretion. This substudy of a randomized crossover trial investigated eight healthy young men on two separate occasions; (I) following an overnight fast (healthy conditions/HC) and (II) fasting and bedrest combined with two lipopolysaccharide (LPS) injections of 1 ng kg−1 following an overnight fast and 0.5 ng kg−1 following another 24 h (systemic inflammation/SI). A standardized protein beverage and a SmartPill capsule (a wireless gastrointestinal monitoring system) were swallowed during each occasion. Whole gut transit time was comparable between HC and SI. SI decreased gastric mean pressure peak amplitude (p = 0.04) and increased pH rise across the pylorus and small bowel pH (p = 0.02) compared with HC. Glucagon‐like peptide‐1 was elevated during SI compared with HC (p = 0.04). Peptide YY was lower during SI compared with HC (p = 0.007). Prolonged LPS exposure combined with fasting and bedrest elevated glucagon‐like peptide 1 concentrations, which may play a role for the nausea and loss of appetite typically associated with SI. |
| first_indexed | 2024-04-12T03:09:56Z |
| format | Article |
| id | doaj.art-de35ba70c46f41b9a3d8b2b2bd5c84fc |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-04-12T03:09:56Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-de35ba70c46f41b9a3d8b2b2bd5c84fc2022-12-22T03:50:24ZengWileyPhysiological Reports2051-817X2022-09-011018n/an/a10.14814/phy2.15462Prolonged lipopolysaccharide‐induced illness elevates glucagon‐like peptide‐1 and suppresses peptide YY: A human‐randomized cross‐over trialKatrine Brodersen0Maike Mose1Ulla Ramer Mikkelsen2Jens Otto Lunde Jørgensen3Michael Festersen Nielsen4Niels Møller5Anne‐Marie Wegeberg6Christina Brock7Bolette Hartmann8Jens Juul Holst9Nikolaj Rittig10Department of Surgery Viborg Regional Hospital Viborg DenmarkMedical/Steno Aarhus Research Laboratory Aarhus University Hospital, Aarhus University Aarhus DenmarkArla Foods Ingredients Group P/S Viby DenmarkMedical/Steno Aarhus Research Laboratory Aarhus University Hospital, Aarhus University Aarhus DenmarkDepartment of Surgery Viborg Regional Hospital Viborg DenmarkMedical/Steno Aarhus Research Laboratory Aarhus University Hospital, Aarhus University Aarhus DenmarkMech‐Sense, Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg DenmarkMech‐Sense, Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg DenmarkDepartment of Biomedical Sciences and Novo Nordisk Foundation Center for Basic Metabolic Research University of Copenhagen København DenmarkDepartment of Biomedical Sciences and Novo Nordisk Foundation Center for Basic Metabolic Research University of Copenhagen København DenmarkMedical/Steno Aarhus Research Laboratory Aarhus University Hospital, Aarhus University Aarhus DenmarkAbstract Severe systemic inflammation is associated with nausea, loss of appetite, and delayed gastric emptying, which increases hospitalization admission length and mortality rate. There is a lack of human controlled studies exploring gastric emptying rates and underlying mechanisms during inflammatory conditions. We aimed to investigate if systemic inflammation in young men delays gastro‐intestinal transit times, lowers motility, and affects gastrointestinal hormone secretion. This substudy of a randomized crossover trial investigated eight healthy young men on two separate occasions; (I) following an overnight fast (healthy conditions/HC) and (II) fasting and bedrest combined with two lipopolysaccharide (LPS) injections of 1 ng kg−1 following an overnight fast and 0.5 ng kg−1 following another 24 h (systemic inflammation/SI). A standardized protein beverage and a SmartPill capsule (a wireless gastrointestinal monitoring system) were swallowed during each occasion. Whole gut transit time was comparable between HC and SI. SI decreased gastric mean pressure peak amplitude (p = 0.04) and increased pH rise across the pylorus and small bowel pH (p = 0.02) compared with HC. Glucagon‐like peptide‐1 was elevated during SI compared with HC (p = 0.04). Peptide YY was lower during SI compared with HC (p = 0.007). Prolonged LPS exposure combined with fasting and bedrest elevated glucagon‐like peptide 1 concentrations, which may play a role for the nausea and loss of appetite typically associated with SI.https://doi.org/10.14814/phy2.15462endotoxemiagastrointestinal hormonesgastrointestinal motilitygastrointestinal transit timesinflammationwireless motility capsule |
| spellingShingle | Katrine Brodersen Maike Mose Ulla Ramer Mikkelsen Jens Otto Lunde Jørgensen Michael Festersen Nielsen Niels Møller Anne‐Marie Wegeberg Christina Brock Bolette Hartmann Jens Juul Holst Nikolaj Rittig Prolonged lipopolysaccharide‐induced illness elevates glucagon‐like peptide‐1 and suppresses peptide YY: A human‐randomized cross‐over trial Physiological Reports endotoxemia gastrointestinal hormones gastrointestinal motility gastrointestinal transit times inflammation wireless motility capsule |
| title | Prolonged lipopolysaccharide‐induced illness elevates glucagon‐like peptide‐1 and suppresses peptide YY: A human‐randomized cross‐over trial |
| title_full | Prolonged lipopolysaccharide‐induced illness elevates glucagon‐like peptide‐1 and suppresses peptide YY: A human‐randomized cross‐over trial |
| title_fullStr | Prolonged lipopolysaccharide‐induced illness elevates glucagon‐like peptide‐1 and suppresses peptide YY: A human‐randomized cross‐over trial |
| title_full_unstemmed | Prolonged lipopolysaccharide‐induced illness elevates glucagon‐like peptide‐1 and suppresses peptide YY: A human‐randomized cross‐over trial |
| title_short | Prolonged lipopolysaccharide‐induced illness elevates glucagon‐like peptide‐1 and suppresses peptide YY: A human‐randomized cross‐over trial |
| title_sort | prolonged lipopolysaccharide induced illness elevates glucagon like peptide 1 and suppresses peptide yy a human randomized cross over trial |
| topic | endotoxemia gastrointestinal hormones gastrointestinal motility gastrointestinal transit times inflammation wireless motility capsule |
| url | https://doi.org/10.14814/phy2.15462 |
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