Preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy: A retrospective study
PurposeTo investigate the relationship between baseline clinicopathological and laboratory variables especially hematological parameters and lymphovascular invasion (LVI) in patients who underwent radical prostatectomy (RP).MethodsWe retrospectively evaluated 348 prostate cancer (PCa) patients who u...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1020655/full |
| _version_ | 1828105882368475136 |
|---|---|
| author | Fangming Wang Fangming Wang Jing Liang Feiya Yang Feiya Yang Fei Liu Fei Liu Sujun Han Sujun Han Nianzeng Xing Nianzeng Xing Nianzeng Xing |
| author_facet | Fangming Wang Fangming Wang Jing Liang Feiya Yang Feiya Yang Fei Liu Fei Liu Sujun Han Sujun Han Nianzeng Xing Nianzeng Xing Nianzeng Xing |
| author_sort | Fangming Wang |
| collection | DOAJ |
| description | PurposeTo investigate the relationship between baseline clinicopathological and laboratory variables especially hematological parameters and lymphovascular invasion (LVI) in patients who underwent radical prostatectomy (RP).MethodsWe retrospectively evaluated 348 prostate cancer (PCa) patients who underwent RP in our center between May 2018 and June 2021. We divided them into non-LVI and LVI groups based on LVI status, and compared clinicopathological characteristics between non-LVI and LVI groups. Clinicopathological parameters including age, body mass index (BMI), history of hypertension and diabetes mellitus, neoadjuvant hormonal therapy (NHT), pathological stage T (pT) and lymph node status (pN), ISUP (international society of urological pathology) grade, positive surgical margin (PSM) rate, and hematological parameters containing prostate-specific antigen (PSA), whole blood parameters and inflammatory indexes were collected. The association between the clinicopathological parameters and the presence of LVI was identified by multivariate logistic regression analysis.ResultsThe pathological results of the RP specimen consisted of 53 (15.2%) patients with LVI and 295 (84.8%) cases without LVI. The level of PSA, percentages of advanced pT and grade, pN1, and PSM were significantly higher in the LVI group when compared with the non-LVI counterpart (p<0.001, p<0.001, p<0.001, p<0.001, p=0.007, respectively). Among the whole blood parameters, only red cell distribution width (RDW) was significantly different (41.2 ± 2.5 vs. 42.1 ± 3.1, p=0.035). Multivariate regression analysis demonstrated that RDW and NHT were negatively correlated with the presence of LVI (OR = 0.870, p=0.024; OR = 0.410, p=0.025), while PSA, ISUP, and pT were positively correlated with the presence of LVI (OR=1.013, p=0.005; OR =1.589, p=0.001; OR=1.655, p=0.008) after adjusting for confounding factors.ConclusionsRDW rather than other whole blood parameters was independently and negatively associated with the presence of LVI in PCa patients, suggesting that RDW might play an essential role in PCa invasion. |
| first_indexed | 2024-04-11T10:08:52Z |
| format | Article |
| id | doaj.art-de36cb0b4be94f1b9ec9c308b076e2d1 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T10:08:52Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-de36cb0b4be94f1b9ec9c308b076e2d12022-12-22T04:30:10ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-10-011310.3389/fendo.2022.10206551020655Preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy: A retrospective studyFangming Wang0Fangming Wang1Jing Liang2Feiya Yang3Feiya Yang4Fei Liu5Fei Liu6Sujun Han7Sujun Han8Nianzeng Xing9Nianzeng Xing10Nianzeng Xing11Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaState Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaState Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaState Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaState Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaState Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Urology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, ChinaPurposeTo investigate the relationship between baseline clinicopathological and laboratory variables especially hematological parameters and lymphovascular invasion (LVI) in patients who underwent radical prostatectomy (RP).MethodsWe retrospectively evaluated 348 prostate cancer (PCa) patients who underwent RP in our center between May 2018 and June 2021. We divided them into non-LVI and LVI groups based on LVI status, and compared clinicopathological characteristics between non-LVI and LVI groups. Clinicopathological parameters including age, body mass index (BMI), history of hypertension and diabetes mellitus, neoadjuvant hormonal therapy (NHT), pathological stage T (pT) and lymph node status (pN), ISUP (international society of urological pathology) grade, positive surgical margin (PSM) rate, and hematological parameters containing prostate-specific antigen (PSA), whole blood parameters and inflammatory indexes were collected. The association between the clinicopathological parameters and the presence of LVI was identified by multivariate logistic regression analysis.ResultsThe pathological results of the RP specimen consisted of 53 (15.2%) patients with LVI and 295 (84.8%) cases without LVI. The level of PSA, percentages of advanced pT and grade, pN1, and PSM were significantly higher in the LVI group when compared with the non-LVI counterpart (p<0.001, p<0.001, p<0.001, p<0.001, p=0.007, respectively). Among the whole blood parameters, only red cell distribution width (RDW) was significantly different (41.2 ± 2.5 vs. 42.1 ± 3.1, p=0.035). Multivariate regression analysis demonstrated that RDW and NHT were negatively correlated with the presence of LVI (OR = 0.870, p=0.024; OR = 0.410, p=0.025), while PSA, ISUP, and pT were positively correlated with the presence of LVI (OR=1.013, p=0.005; OR =1.589, p=0.001; OR=1.655, p=0.008) after adjusting for confounding factors.ConclusionsRDW rather than other whole blood parameters was independently and negatively associated with the presence of LVI in PCa patients, suggesting that RDW might play an essential role in PCa invasion.https://www.frontiersin.org/articles/10.3389/fendo.2022.1020655/fullred blood cell distribution widthlymphovascular invasionprostate cancerradical prostatectomyhematological parameters |
| spellingShingle | Fangming Wang Fangming Wang Jing Liang Feiya Yang Feiya Yang Fei Liu Fei Liu Sujun Han Sujun Han Nianzeng Xing Nianzeng Xing Nianzeng Xing Preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy: A retrospective study Frontiers in Endocrinology red blood cell distribution width lymphovascular invasion prostate cancer radical prostatectomy hematological parameters |
| title | Preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy: A retrospective study |
| title_full | Preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy: A retrospective study |
| title_fullStr | Preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy: A retrospective study |
| title_full_unstemmed | Preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy: A retrospective study |
| title_short | Preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy: A retrospective study |
| title_sort | preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy a retrospective study |
| topic | red blood cell distribution width lymphovascular invasion prostate cancer radical prostatectomy hematological parameters |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1020655/full |
| work_keys_str_mv | AT fangmingwang preoperativeredcelldistributionwidthisassociatedwithpostoperativelymphovascularinvasioninprostatecancerpatientstreatedwithradicalprostatectomyaretrospectivestudy AT fangmingwang preoperativeredcelldistributionwidthisassociatedwithpostoperativelymphovascularinvasioninprostatecancerpatientstreatedwithradicalprostatectomyaretrospectivestudy AT jingliang preoperativeredcelldistributionwidthisassociatedwithpostoperativelymphovascularinvasioninprostatecancerpatientstreatedwithradicalprostatectomyaretrospectivestudy AT feiyayang preoperativeredcelldistributionwidthisassociatedwithpostoperativelymphovascularinvasioninprostatecancerpatientstreatedwithradicalprostatectomyaretrospectivestudy AT feiyayang preoperativeredcelldistributionwidthisassociatedwithpostoperativelymphovascularinvasioninprostatecancerpatientstreatedwithradicalprostatectomyaretrospectivestudy AT feiliu preoperativeredcelldistributionwidthisassociatedwithpostoperativelymphovascularinvasioninprostatecancerpatientstreatedwithradicalprostatectomyaretrospectivestudy AT feiliu preoperativeredcelldistributionwidthisassociatedwithpostoperativelymphovascularinvasioninprostatecancerpatientstreatedwithradicalprostatectomyaretrospectivestudy AT sujunhan preoperativeredcelldistributionwidthisassociatedwithpostoperativelymphovascularinvasioninprostatecancerpatientstreatedwithradicalprostatectomyaretrospectivestudy AT sujunhan preoperativeredcelldistributionwidthisassociatedwithpostoperativelymphovascularinvasioninprostatecancerpatientstreatedwithradicalprostatectomyaretrospectivestudy AT nianzengxing preoperativeredcelldistributionwidthisassociatedwithpostoperativelymphovascularinvasioninprostatecancerpatientstreatedwithradicalprostatectomyaretrospectivestudy AT nianzengxing preoperativeredcelldistributionwidthisassociatedwithpostoperativelymphovascularinvasioninprostatecancerpatientstreatedwithradicalprostatectomyaretrospectivestudy AT nianzengxing preoperativeredcelldistributionwidthisassociatedwithpostoperativelymphovascularinvasioninprostatecancerpatientstreatedwithradicalprostatectomyaretrospectivestudy |