FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis
Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue. Here the authors show that FGF6 and FGF9 induce UCP1 expression in adipocytes and preadipocytes, via modulation of a transcriptional network that is dissociated from brown adipogenesis.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15055-9 |
| _version_ | 1818750578510004224 |
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| author | Farnaz Shamsi Ruidan Xue Tian Lian Huang Morten Lundh Yang Liu Luiz O. Leiria Matthew D. Lynes Elena Kempf Chih-Hao Wang Satoru Sugimoto Pasquale Nigro Kathrin Landgraf Tim Schulz Yiming Li Brice Emanuelli Srinivas Kothakota Lewis T. Williams Niels Jessen Steen Bønløkke Pedersen Yvonne Böttcher Matthias Blüher Antje Körner Laurie J. Goodyear Moosa Mohammadi C. Ronald Kahn Yu-Hua Tseng |
| author_facet | Farnaz Shamsi Ruidan Xue Tian Lian Huang Morten Lundh Yang Liu Luiz O. Leiria Matthew D. Lynes Elena Kempf Chih-Hao Wang Satoru Sugimoto Pasquale Nigro Kathrin Landgraf Tim Schulz Yiming Li Brice Emanuelli Srinivas Kothakota Lewis T. Williams Niels Jessen Steen Bønløkke Pedersen Yvonne Böttcher Matthias Blüher Antje Körner Laurie J. Goodyear Moosa Mohammadi C. Ronald Kahn Yu-Hua Tseng |
| author_sort | Farnaz Shamsi |
| collection | DOAJ |
| description | Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue. Here the authors show that FGF6 and FGF9 induce UCP1 expression in adipocytes and preadipocytes, via modulation of a transcriptional network that is dissociated from brown adipogenesis. |
| first_indexed | 2024-12-18T04:21:54Z |
| format | Article |
| id | doaj.art-de377e337a5a402280aaea762fc97cbe |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:21:54Z |
| publishDate | 2020-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-de377e337a5a402280aaea762fc97cbe2022-12-21T21:21:12ZengNature PortfolioNature Communications2041-17232020-03-0111111610.1038/s41467-020-15055-9FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesisFarnaz Shamsi0Ruidan Xue1Tian Lian Huang2Morten Lundh3Yang Liu4Luiz O. Leiria5Matthew D. Lynes6Elena Kempf7Chih-Hao Wang8Satoru Sugimoto9Pasquale Nigro10Kathrin Landgraf11Tim Schulz12Yiming Li13Brice Emanuelli14Srinivas Kothakota15Lewis T. Williams16Niels Jessen17Steen Bønløkke Pedersen18Yvonne Böttcher19Matthias Blüher20Antje Körner21Laurie J. Goodyear22Moosa Mohammadi23C. Ronald Kahn24Yu-Hua Tseng25Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolDepartment of Biochemistry and Molecular Pharmacology, New York University School of MedicineSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolCenter for Pediatric Research Leipzig, University Hospital for Children and Adolescents, University of LeipzigSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolDivision of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan UniversityThe Novo Nordisk Foundation Center for Basic Metabolic Research, University of CopenhagenFive Prime TherapeuticsFive Prime TherapeuticsSteno Diabetes Center Aarhus, Aarhus University HospitalSteno Diabetes Center Aarhus, Aarhus University HospitalInstitute of Clinical Medicine, University of OsloDepartment of Internal Medicine (Endocrinology and Nephrology), University of LeipzigCenter for Pediatric Research Leipzig, University Hospital for Children and Adolescents, University of LeipzigSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolDepartment of Biochemistry and Molecular Pharmacology, New York University School of MedicineSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical SchoolUncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue. Here the authors show that FGF6 and FGF9 induce UCP1 expression in adipocytes and preadipocytes, via modulation of a transcriptional network that is dissociated from brown adipogenesis.https://doi.org/10.1038/s41467-020-15055-9 |
| spellingShingle | Farnaz Shamsi Ruidan Xue Tian Lian Huang Morten Lundh Yang Liu Luiz O. Leiria Matthew D. Lynes Elena Kempf Chih-Hao Wang Satoru Sugimoto Pasquale Nigro Kathrin Landgraf Tim Schulz Yiming Li Brice Emanuelli Srinivas Kothakota Lewis T. Williams Niels Jessen Steen Bønløkke Pedersen Yvonne Böttcher Matthias Blüher Antje Körner Laurie J. Goodyear Moosa Mohammadi C. Ronald Kahn Yu-Hua Tseng FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis Nature Communications |
| title | FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis |
| title_full | FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis |
| title_fullStr | FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis |
| title_full_unstemmed | FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis |
| title_short | FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis |
| title_sort | fgf6 and fgf9 regulate ucp1 expression independent of brown adipogenesis |
| url | https://doi.org/10.1038/s41467-020-15055-9 |
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