Knockout of Trpa1 accelerates age-related cardiac fibrosis and dysfunction.

Knockout of Trpa1 accelerates age-related cardiac fibrosis and dysfunction.

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Age-related cardiac fibrosis contributes to the development of heart failure with preserved ejection fraction which lacks ideal treatment. Transient receptor potential ankyrin 1 (TRPA1) is an oxidative stress sensor and could attenuate age-related pathologies in invertebrates. The present study aime...

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Bibliographic Details
Main Authors: Shuangtao Ma, Donna H Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0274618

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