Design and Development of Low- and Medium-Viscosity Alginate Beads Loaded with Pluronic<sup>®</sup> F-127 Nanomicelles
The anionic polymer sodium alginate, a linear copolymer of guluronic and mannuronic acids, is primarily present in brown algae. Copolymers are used in the sodium alginate preparation process to confer on the material strength and flexibility. Micelles and other polymeric nanoparticles are frequently...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | Materials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1996-1944/16/13/4715 |
| _version_ | 1797591380350992384 |
|---|---|
| author | Flora Kalogeropoulou Dimitra Papailiou Chrystalla Protopapa Angeliki Siamidi Leto-Aikaterini Tziveleka Natassa Pippa Marilena Vlachou |
| author_facet | Flora Kalogeropoulou Dimitra Papailiou Chrystalla Protopapa Angeliki Siamidi Leto-Aikaterini Tziveleka Natassa Pippa Marilena Vlachou |
| author_sort | Flora Kalogeropoulou |
| collection | DOAJ |
| description | The anionic polymer sodium alginate, a linear copolymer of guluronic and mannuronic acids, is primarily present in brown algae. Copolymers are used in the sodium alginate preparation process to confer on the material strength and flexibility. Micelles and other polymeric nanoparticles are frequently made using the triblock copolymer Pluronic<sup>®</sup> F-127. The purpose of the present study is to determine the effect of sodium alginate’s viscosity (low and medium) and the presence of Pluronic<sup>®</sup> F-127 micelles on the swelling behavior of the prepared pure beads and those loaded with Pluronic<sup>®</sup> F-127 micelles. The Pluronic<sup>®</sup> F-127 nanomicelles have a size of 120 nm. The swelling studies were carried out at pH = 1.2 (simulated gastric fluid-SGF) for two hours and at pH = 6.8 (simulated intestinal fluid-SIF) for four more hours. The swelling of both low- and medium-viscosity alginate beads was minor at pH = 1.2, irrespective of the use of Pluronic<sup>®</sup> F-127 nanomicelles. At pH = 6.8, without Pluronic<sup>®</sup> F-127, the beads showed an enhanced swelling ratio for the first four hours, which was even higher in the medium-viscosity alginate beads. With the addition of Pluronic<sup>®</sup> F-127, the beads were dissolved in the first and second hour, in the case of the low- and medium-alginate’s viscosity, respectively. In other words, the behavior of the mixed hydrogels was the same during the swelling experiments. Therefore, the presence of Pluronic<sup>®</sup> F-127 nanomicelles and medium-viscosity sodium alginate leads to a higher swelling ratio. A model drug, acetyl salicylic acid (ASA), was also encapsulated in the mixed beads and ASA’s release studies were performed. In conclusion, the prepared systems, which are well characterized, show potential as delivery platforms for the oral delivery of active pharmaceutical ingredients and biopharmaceuticals. |
| first_indexed | 2024-03-11T01:36:35Z |
| format | Article |
| id | doaj.art-de3a4e1782fe4b859632ca0095614fe7 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-11T01:36:35Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-de3a4e1782fe4b859632ca0095614fe72023-11-18T16:58:48ZengMDPI AGMaterials1996-19442023-06-011613471510.3390/ma16134715Design and Development of Low- and Medium-Viscosity Alginate Beads Loaded with Pluronic<sup>®</sup> F-127 NanomicellesFlora Kalogeropoulou0Dimitra Papailiou1Chrystalla Protopapa2Angeliki Siamidi3Leto-Aikaterini Tziveleka4Natassa Pippa5Marilena Vlachou6Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, GreeceSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, GreeceSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, GreeceSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, GreeceSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, GreeceSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, GreeceThe anionic polymer sodium alginate, a linear copolymer of guluronic and mannuronic acids, is primarily present in brown algae. Copolymers are used in the sodium alginate preparation process to confer on the material strength and flexibility. Micelles and other polymeric nanoparticles are frequently made using the triblock copolymer Pluronic<sup>®</sup> F-127. The purpose of the present study is to determine the effect of sodium alginate’s viscosity (low and medium) and the presence of Pluronic<sup>®</sup> F-127 micelles on the swelling behavior of the prepared pure beads and those loaded with Pluronic<sup>®</sup> F-127 micelles. The Pluronic<sup>®</sup> F-127 nanomicelles have a size of 120 nm. The swelling studies were carried out at pH = 1.2 (simulated gastric fluid-SGF) for two hours and at pH = 6.8 (simulated intestinal fluid-SIF) for four more hours. The swelling of both low- and medium-viscosity alginate beads was minor at pH = 1.2, irrespective of the use of Pluronic<sup>®</sup> F-127 nanomicelles. At pH = 6.8, without Pluronic<sup>®</sup> F-127, the beads showed an enhanced swelling ratio for the first four hours, which was even higher in the medium-viscosity alginate beads. With the addition of Pluronic<sup>®</sup> F-127, the beads were dissolved in the first and second hour, in the case of the low- and medium-alginate’s viscosity, respectively. In other words, the behavior of the mixed hydrogels was the same during the swelling experiments. Therefore, the presence of Pluronic<sup>®</sup> F-127 nanomicelles and medium-viscosity sodium alginate leads to a higher swelling ratio. A model drug, acetyl salicylic acid (ASA), was also encapsulated in the mixed beads and ASA’s release studies were performed. In conclusion, the prepared systems, which are well characterized, show potential as delivery platforms for the oral delivery of active pharmaceutical ingredients and biopharmaceuticals.https://www.mdpi.com/1996-1944/16/13/4715hydrogelsPluronic<sup>®</sup> F-127crosslinkingswelling studiesviscosityalginate beads |
| spellingShingle | Flora Kalogeropoulou Dimitra Papailiou Chrystalla Protopapa Angeliki Siamidi Leto-Aikaterini Tziveleka Natassa Pippa Marilena Vlachou Design and Development of Low- and Medium-Viscosity Alginate Beads Loaded with Pluronic<sup>®</sup> F-127 Nanomicelles Materials hydrogels Pluronic<sup>®</sup> F-127 crosslinking swelling studies viscosity alginate beads |
| title | Design and Development of Low- and Medium-Viscosity Alginate Beads Loaded with Pluronic<sup>®</sup> F-127 Nanomicelles |
| title_full | Design and Development of Low- and Medium-Viscosity Alginate Beads Loaded with Pluronic<sup>®</sup> F-127 Nanomicelles |
| title_fullStr | Design and Development of Low- and Medium-Viscosity Alginate Beads Loaded with Pluronic<sup>®</sup> F-127 Nanomicelles |
| title_full_unstemmed | Design and Development of Low- and Medium-Viscosity Alginate Beads Loaded with Pluronic<sup>®</sup> F-127 Nanomicelles |
| title_short | Design and Development of Low- and Medium-Viscosity Alginate Beads Loaded with Pluronic<sup>®</sup> F-127 Nanomicelles |
| title_sort | design and development of low and medium viscosity alginate beads loaded with pluronic sup r sup f 127 nanomicelles |
| topic | hydrogels Pluronic<sup>®</sup> F-127 crosslinking swelling studies viscosity alginate beads |
| url | https://www.mdpi.com/1996-1944/16/13/4715 |
| work_keys_str_mv | AT florakalogeropoulou designanddevelopmentoflowandmediumviscosityalginatebeadsloadedwithpluronicsupsupf127nanomicelles AT dimitrapapailiou designanddevelopmentoflowandmediumviscosityalginatebeadsloadedwithpluronicsupsupf127nanomicelles AT chrystallaprotopapa designanddevelopmentoflowandmediumviscosityalginatebeadsloadedwithpluronicsupsupf127nanomicelles AT angelikisiamidi designanddevelopmentoflowandmediumviscosityalginatebeadsloadedwithpluronicsupsupf127nanomicelles AT letoaikaterinitziveleka designanddevelopmentoflowandmediumviscosityalginatebeadsloadedwithpluronicsupsupf127nanomicelles AT natassapippa designanddevelopmentoflowandmediumviscosityalginatebeadsloadedwithpluronicsupsupf127nanomicelles AT marilenavlachou designanddevelopmentoflowandmediumviscosityalginatebeadsloadedwithpluronicsupsupf127nanomicelles |