Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1G93A ALS Mice

Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1G93A ALS Mice

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting the neuromuscular system for which currently there is no effective therapy. Motoneuron (MN) degeneration involves several complex mechanisms, including surrounding glial cells and skeletal muscle contributions. Neureg...

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Bibliographic Details
Main Authors: Guillem Mòdol-Caballero, Mireia Herrando-Grabulosa, Sergi Verdés, Belén García-Lareu, Neus Hernández, Isaac Francos-Quijorna, Rubén López-Vales, Assumpció Bosch, Xavier Navarro
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neurology
Subjects:
amyotrophic lateral sclerosis
neuregulin 1
ErbB receptors
motoneuron
neuromuscular junction
spinal cord
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.693309/full

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