International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat
Abstract Background Benzydamine hydrochloride is a locally-acting Non-Steroidal Anti-Inflammatory Drug (NSAID) with combined local anesthetic and analgesic properties, indicated for the symptomatic relief of pain in acute sore throat. The aim of this study was to obtain an European Consensus among p...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-11-01
|
| Series: | BMC Primary Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12875-022-01901-w |
| _version_ | 1811186977480900608 |
|---|---|
| author | Desiderio Passali Veronica Barat Olga Cadevall Hugo Miguel Freire Ignazio Grattagliano Ioan Gutu Ralph Mösges Andrey Pavlysh |
| author_facet | Desiderio Passali Veronica Barat Olga Cadevall Hugo Miguel Freire Ignazio Grattagliano Ioan Gutu Ralph Mösges Andrey Pavlysh |
| author_sort | Desiderio Passali |
| collection | DOAJ |
| description | Abstract Background Benzydamine hydrochloride is a locally-acting Non-Steroidal Anti-Inflammatory Drug (NSAID) with combined local anesthetic and analgesic properties, indicated for the symptomatic relief of pain in acute sore throat. The aim of this study was to obtain an European Consensus among pharmacists, general practitioners and pediatricians on the appropriate use of benzydamine hydrochloride in the treatment of sore throat. Methods The authors developed a Delphi questionnaire organized into 15 statements focused on 4 topics: the mechanism of action of benzydamine, the benzydamine treatment in an adult patient and in a pediatric patient, and the advantages of benzydamine over other topical treatments. The survey was administered to a panel of to 320 participants including general practitioners, pediatricians, and pharmacists from 6 European countries (Italy, Germany, Portugal, Romania, Russia, and Spain), who rated their level of agreement or disagreement with each statement on a 6-point Likert scale. Consensus was predefined as more than 66% of the panel agreeing/disagreeing with each statement. Results Panelists’ agreement on statements was very high. Consensus was reached for all 15 statements in the Delphi survey, with more than 98% positive agreement on topic 4, suggesting a shared view among European healthcare professionals (HCPs) about the advantages of benzydamine over other topical treatments. A strong consensus (> 99%) was reached for all the statements of topic 1 regarding the mechanism of action of benzydamine, except for its anesthetic properties (79%). Strong agreement was reached for all statements in topics 2 and 3 regarding the treatment of acute sore throat symptoms in the adult and pediatric patient, except for one on the efficacy of benzydamine in preventing post-operative sore throat, for which it was 67%. Conclusion Because all relevant publications on benzydamine are dated and there are no recommendations on its use for the symptomatic treatment of sore throat in European guidelines, this Delphi-based international consensus may be important in reinforcing the appropriate use and effect of benzydamine in the treatment of sore throat among health care professionals. |
| first_indexed | 2024-04-11T13:54:20Z |
| format | Article |
| id | doaj.art-de3ace296d764dc1ae69fa8d12170707 |
| institution | Directory Open Access Journal |
| issn | 2731-4553 |
| language | English |
| last_indexed | 2024-04-11T13:54:20Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Primary Care |
| spelling | doaj.art-de3ace296d764dc1ae69fa8d121707072022-12-22T04:20:24ZengBMCBMC Primary Care2731-45532022-11-012311810.1186/s12875-022-01901-wInternational Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throatDesiderio Passali0Veronica Barat1Olga Cadevall2Hugo Miguel Freire3Ignazio Grattagliano4Ioan Gutu5Ralph Mösges6Andrey Pavlysh7International Federation ORL Societies (IFOS) Executive Board membersAOU Città della Salute e della Scienza di Torino, Regina Margherita Children’s HospitalClínica Rotger, QuirónsaludSociedade Portuguesa de Farmacêuticos dos Cuidados de SaúdeItalian College of General Practitioners and Primary CareGeneral PractitionerInstitute of Medical Statistics, and Computational Biology (IMSB), Medical Faculty, University at CologneNorth-Western State Medical University named after I.I. MechnikovAbstract Background Benzydamine hydrochloride is a locally-acting Non-Steroidal Anti-Inflammatory Drug (NSAID) with combined local anesthetic and analgesic properties, indicated for the symptomatic relief of pain in acute sore throat. The aim of this study was to obtain an European Consensus among pharmacists, general practitioners and pediatricians on the appropriate use of benzydamine hydrochloride in the treatment of sore throat. Methods The authors developed a Delphi questionnaire organized into 15 statements focused on 4 topics: the mechanism of action of benzydamine, the benzydamine treatment in an adult patient and in a pediatric patient, and the advantages of benzydamine over other topical treatments. The survey was administered to a panel of to 320 participants including general practitioners, pediatricians, and pharmacists from 6 European countries (Italy, Germany, Portugal, Romania, Russia, and Spain), who rated their level of agreement or disagreement with each statement on a 6-point Likert scale. Consensus was predefined as more than 66% of the panel agreeing/disagreeing with each statement. Results Panelists’ agreement on statements was very high. Consensus was reached for all 15 statements in the Delphi survey, with more than 98% positive agreement on topic 4, suggesting a shared view among European healthcare professionals (HCPs) about the advantages of benzydamine over other topical treatments. A strong consensus (> 99%) was reached for all the statements of topic 1 regarding the mechanism of action of benzydamine, except for its anesthetic properties (79%). Strong agreement was reached for all statements in topics 2 and 3 regarding the treatment of acute sore throat symptoms in the adult and pediatric patient, except for one on the efficacy of benzydamine in preventing post-operative sore throat, for which it was 67%. Conclusion Because all relevant publications on benzydamine are dated and there are no recommendations on its use for the symptomatic treatment of sore throat in European guidelines, this Delphi-based international consensus may be important in reinforcing the appropriate use and effect of benzydamine in the treatment of sore throat among health care professionals.https://doi.org/10.1186/s12875-022-01901-wSore throatBenzydamineOropharynxDelphi-based consensusGeneral practitionerPharmacists |
| spellingShingle | Desiderio Passali Veronica Barat Olga Cadevall Hugo Miguel Freire Ignazio Grattagliano Ioan Gutu Ralph Mösges Andrey Pavlysh International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat BMC Primary Care Sore throat Benzydamine Oropharynx Delphi-based consensus General practitioner Pharmacists |
| title | International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat |
| title_full | International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat |
| title_fullStr | International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat |
| title_full_unstemmed | International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat |
| title_short | International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat |
| title_sort | international delphi based consensus on the appropriate use and effect of benzydamine hydrochloride in the treatment of sore throat |
| topic | Sore throat Benzydamine Oropharynx Delphi-based consensus General practitioner Pharmacists |
| url | https://doi.org/10.1186/s12875-022-01901-w |
| work_keys_str_mv | AT desideriopassali internationaldelphibasedconsensusontheappropriateuseandeffectofbenzydaminehydrochlorideinthetreatmentofsorethroat AT veronicabarat internationaldelphibasedconsensusontheappropriateuseandeffectofbenzydaminehydrochlorideinthetreatmentofsorethroat AT olgacadevall internationaldelphibasedconsensusontheappropriateuseandeffectofbenzydaminehydrochlorideinthetreatmentofsorethroat AT hugomiguelfreire internationaldelphibasedconsensusontheappropriateuseandeffectofbenzydaminehydrochlorideinthetreatmentofsorethroat AT ignaziograttagliano internationaldelphibasedconsensusontheappropriateuseandeffectofbenzydaminehydrochlorideinthetreatmentofsorethroat AT ioangutu internationaldelphibasedconsensusontheappropriateuseandeffectofbenzydaminehydrochlorideinthetreatmentofsorethroat AT ralphmosges internationaldelphibasedconsensusontheappropriateuseandeffectofbenzydaminehydrochlorideinthetreatmentofsorethroat AT andreypavlysh internationaldelphibasedconsensusontheappropriateuseandeffectofbenzydaminehydrochlorideinthetreatmentofsorethroat |