Autophagy/Mitophagy Regulated by Ubiquitination: A Promising Pathway in Cancer Therapeutics
Autophagy is essential for organismal development, maintenance of energy homeostasis, and quality control of organelles and proteins. As a selective form of autophagy, mitophagy is necessary for effectively eliminating dysfunctional mitochondria. Both autophagy and mitophagy are linked with tumor pr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/4/1112 |
| _version_ | 1797621893765791744 |
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| author | Seung-Cheol Jee Heesun Cheong |
| author_facet | Seung-Cheol Jee Heesun Cheong |
| author_sort | Seung-Cheol Jee |
| collection | DOAJ |
| description | Autophagy is essential for organismal development, maintenance of energy homeostasis, and quality control of organelles and proteins. As a selective form of autophagy, mitophagy is necessary for effectively eliminating dysfunctional mitochondria. Both autophagy and mitophagy are linked with tumor progression and inhibition. The regulation of mitophagy and autophagy depend upon tumor type and stage. In tumors, mitophagy has dual roles: it removes damaged mitochondria to maintain healthy mitochondria and energy production, which are necessary for tumor growth. In contrast, mitophagy has been shown to inhibit tumor growth by mitigating excessive ROS production, thus preventing mutation and chromosomal instability. Ubiquitination and deubiquitination are important modifications that regulate autophagy. Multiple E3 ubiquitin ligases and DUBs modulate the activity of the autophagy and mitophagy machinery, thereby influencing cancer progression. In this review, we summarize the mechanistic association between cancer development and autophagy/mitophagy activities regulated by the ubiquitin modification of autophagic proteins. In addition, we discuss the function of multiple proteins involved in autophagy/mitophagy in tumors that may represent potential therapeutic targets. |
| first_indexed | 2024-03-11T09:03:28Z |
| format | Article |
| id | doaj.art-de3cd3b086b94ec6b3fb05a418d2a542 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:03:28Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-de3cd3b086b94ec6b3fb05a418d2a5422023-11-16T19:36:20ZengMDPI AGCancers2072-66942023-02-01154111210.3390/cancers15041112Autophagy/Mitophagy Regulated by Ubiquitination: A Promising Pathway in Cancer TherapeuticsSeung-Cheol Jee0Heesun Cheong1Division of Cancer Biology, Research Institute, National Cancer Center, Goyang-si 10408, Republic of KoreaDivision of Cancer Biology, Research Institute, National Cancer Center, Goyang-si 10408, Republic of KoreaAutophagy is essential for organismal development, maintenance of energy homeostasis, and quality control of organelles and proteins. As a selective form of autophagy, mitophagy is necessary for effectively eliminating dysfunctional mitochondria. Both autophagy and mitophagy are linked with tumor progression and inhibition. The regulation of mitophagy and autophagy depend upon tumor type and stage. In tumors, mitophagy has dual roles: it removes damaged mitochondria to maintain healthy mitochondria and energy production, which are necessary for tumor growth. In contrast, mitophagy has been shown to inhibit tumor growth by mitigating excessive ROS production, thus preventing mutation and chromosomal instability. Ubiquitination and deubiquitination are important modifications that regulate autophagy. Multiple E3 ubiquitin ligases and DUBs modulate the activity of the autophagy and mitophagy machinery, thereby influencing cancer progression. In this review, we summarize the mechanistic association between cancer development and autophagy/mitophagy activities regulated by the ubiquitin modification of autophagic proteins. In addition, we discuss the function of multiple proteins involved in autophagy/mitophagy in tumors that may represent potential therapeutic targets.https://www.mdpi.com/2072-6694/15/4/1112autophagymitophagyubiquitinationdeubiquitinationcancer |
| spellingShingle | Seung-Cheol Jee Heesun Cheong Autophagy/Mitophagy Regulated by Ubiquitination: A Promising Pathway in Cancer Therapeutics Cancers autophagy mitophagy ubiquitination deubiquitination cancer |
| title | Autophagy/Mitophagy Regulated by Ubiquitination: A Promising Pathway in Cancer Therapeutics |
| title_full | Autophagy/Mitophagy Regulated by Ubiquitination: A Promising Pathway in Cancer Therapeutics |
| title_fullStr | Autophagy/Mitophagy Regulated by Ubiquitination: A Promising Pathway in Cancer Therapeutics |
| title_full_unstemmed | Autophagy/Mitophagy Regulated by Ubiquitination: A Promising Pathway in Cancer Therapeutics |
| title_short | Autophagy/Mitophagy Regulated by Ubiquitination: A Promising Pathway in Cancer Therapeutics |
| title_sort | autophagy mitophagy regulated by ubiquitination a promising pathway in cancer therapeutics |
| topic | autophagy mitophagy ubiquitination deubiquitination cancer |
| url | https://www.mdpi.com/2072-6694/15/4/1112 |
| work_keys_str_mv | AT seungcheoljee autophagymitophagyregulatedbyubiquitinationapromisingpathwayincancertherapeutics AT heesuncheong autophagymitophagyregulatedbyubiquitinationapromisingpathwayincancertherapeutics |