D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials for a Dual-Mode Magnetic Resonance Imaging Contrast Agent and Hyperthermia Treatments
Manganese-zinc ferrite (MZF) is known as high-performance magnetic material and has been used in many fields and development. In the biomedical applications, the biocompatible MZF formulation attracted much attention. In this study, water-soluble amphiphilic vitamin E (TPGS, d-alpha-tocopheryl poly(...
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MDPI AG
2022-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/5/1000 |
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| author | Lin Wang Syu-Ming Lai Cun-Zhao Li Hsiu-Ping Yu Parthiban Venkatesan Ping-Shan Lai |
| author_facet | Lin Wang Syu-Ming Lai Cun-Zhao Li Hsiu-Ping Yu Parthiban Venkatesan Ping-Shan Lai |
| author_sort | Lin Wang |
| collection | DOAJ |
| description | Manganese-zinc ferrite (MZF) is known as high-performance magnetic material and has been used in many fields and development. In the biomedical applications, the biocompatible MZF formulation attracted much attention. In this study, water-soluble amphiphilic vitamin E (TPGS, d-alpha-tocopheryl poly(ethylene glycol 1000) succinate) formulated MZF nanoparticles were synthesized to serve as both a magnetic resonance imaging (MRI) contrast agent and a vehicle for creating magnetically induced hyperthermia against cancer. The MZF nanoparticles were synthesized from a metallic acetylacetonate in an organic phase and further modified with TPGS using an emulsion and solvent-evaporation method. The resulting TPGS-modified MZF nanoparticles exhibited a dual-contrast ability, with a longitudinal relaxivity (35.22 s<sup>−1</sup> mM Fe<sup>−1</sup>) and transverse relaxivity (237.94 s<sup>−1</sup> mM Fe<sup>−1</sup>) that were both higher than Resovist<sup>®</sup>. Furthermore, the TPGS-assisted MZF formulation can be used for hyperthermia treatment to successfully suppress cell viability and tumor growth after applying an alternating current (AC) electromagnetic field at lower amplitude. Thus, the TPGS-assisted MZF theranostics can not only be applied as a potential contrast agent for MRI but also has potential for use in hyperthermia treatments. |
| first_indexed | 2024-03-10T03:07:02Z |
| format | Article |
| id | doaj.art-de3d7d93d609475e959ff2535389465c |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T03:07:02Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-de3d7d93d609475e959ff2535389465c2023-11-23T12:37:55ZengMDPI AGPharmaceutics1999-49232022-05-01145100010.3390/pharmaceutics14051000D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials for a Dual-Mode Magnetic Resonance Imaging Contrast Agent and Hyperthermia TreatmentsLin Wang0Syu-Ming Lai1Cun-Zhao Li2Hsiu-Ping Yu3Parthiban Venkatesan4Ping-Shan Lai5College of Chemistry & Pharmacy, Northwest A&F University, Xianyang 712100, ChinaDepartment of Chemistry, National Chung Hsing University, Taichung 402204, TaiwanDepartment of Chemistry, National Chung Hsing University, Taichung 402204, TaiwanCollege of Chemistry & Pharmacy, Northwest A&F University, Xianyang 712100, ChinaDepartment of Chemistry, National Chung Hsing University, Taichung 402204, TaiwanDepartment of Chemistry, National Chung Hsing University, Taichung 402204, TaiwanManganese-zinc ferrite (MZF) is known as high-performance magnetic material and has been used in many fields and development. In the biomedical applications, the biocompatible MZF formulation attracted much attention. In this study, water-soluble amphiphilic vitamin E (TPGS, d-alpha-tocopheryl poly(ethylene glycol 1000) succinate) formulated MZF nanoparticles were synthesized to serve as both a magnetic resonance imaging (MRI) contrast agent and a vehicle for creating magnetically induced hyperthermia against cancer. The MZF nanoparticles were synthesized from a metallic acetylacetonate in an organic phase and further modified with TPGS using an emulsion and solvent-evaporation method. The resulting TPGS-modified MZF nanoparticles exhibited a dual-contrast ability, with a longitudinal relaxivity (35.22 s<sup>−1</sup> mM Fe<sup>−1</sup>) and transverse relaxivity (237.94 s<sup>−1</sup> mM Fe<sup>−1</sup>) that were both higher than Resovist<sup>®</sup>. Furthermore, the TPGS-assisted MZF formulation can be used for hyperthermia treatment to successfully suppress cell viability and tumor growth after applying an alternating current (AC) electromagnetic field at lower amplitude. Thus, the TPGS-assisted MZF theranostics can not only be applied as a potential contrast agent for MRI but also has potential for use in hyperthermia treatments.https://www.mdpi.com/1999-4923/14/5/1000theranosticmanganese-zinc ferritemagnetic resonance imaginghyperthermiain vivo |
| spellingShingle | Lin Wang Syu-Ming Lai Cun-Zhao Li Hsiu-Ping Yu Parthiban Venkatesan Ping-Shan Lai D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials for a Dual-Mode Magnetic Resonance Imaging Contrast Agent and Hyperthermia Treatments Pharmaceutics theranostic manganese-zinc ferrite magnetic resonance imaging hyperthermia in vivo |
| title | D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials for a Dual-Mode Magnetic Resonance Imaging Contrast Agent and Hyperthermia Treatments |
| title_full | D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials for a Dual-Mode Magnetic Resonance Imaging Contrast Agent and Hyperthermia Treatments |
| title_fullStr | D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials for a Dual-Mode Magnetic Resonance Imaging Contrast Agent and Hyperthermia Treatments |
| title_full_unstemmed | D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials for a Dual-Mode Magnetic Resonance Imaging Contrast Agent and Hyperthermia Treatments |
| title_short | D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials for a Dual-Mode Magnetic Resonance Imaging Contrast Agent and Hyperthermia Treatments |
| title_sort | d alpha tocopheryl poly ethylene glycol 1000 succinate coated manganese zinc ferrite nanomaterials for a dual mode magnetic resonance imaging contrast agent and hyperthermia treatments |
| topic | theranostic manganese-zinc ferrite magnetic resonance imaging hyperthermia in vivo |
| url | https://www.mdpi.com/1999-4923/14/5/1000 |
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