Determination of Tapentadol Hydrochloride in Tablets by Three New Validated Spectrophotometric Methods
Three UV spectrophotometric methods viz. linear regression equation (LRE), standard absorptivity (SA) and first order derivative (FOD) method were developed and validated according to ICH guideline. The methods were linear in the range of 10-50 μg/mL and validated methods were successfully applied f...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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National Centre of Excellence in Analytical Chemsitry
2013-12-01
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| Series: | Pakistan Journal of Analytical & Environmental Chemistry |
| Online Access: | http://ceacsu.edu.pk/PDF%20file/Volume%2014%20No%202/38-43-PJAEC-25062013-18%5B1%5D.pdf |
| _version_ | 1818998135013244928 |
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| author | Deepti Jain Pawan Kumar Basniwal |
| author_facet | Deepti Jain Pawan Kumar Basniwal |
| author_sort | Deepti Jain |
| collection | DOAJ |
| description | Three UV spectrophotometric methods viz. linear regression equation (LRE), standard absorptivity (SA) and first order derivative (FOD) method were developed and validated according to ICH guideline. The methods were linear in the range of 10-50 μg/mL and validated methods were successfully applied for determination of tapentadol hydrochloride content in tablet dosage forms in the range of 100.42-100.64%, 100.31-100.54% and 100.10-100.59%, respectively. The standard deviation for all the methods was found to be less than one unit (0.45-0.83). The validated spectrophotometric methods may be successfully applied for assay, dissolution studies, bio-equivalence studies as well as routine analysis in pharmaceutical industries. |
| first_indexed | 2024-12-20T21:56:42Z |
| format | Article |
| id | doaj.art-de3e0ac4db6e48ffa7012381ba1bf230 |
| institution | Directory Open Access Journal |
| issn | 1996-918X 2221-5255 |
| language | English |
| last_indexed | 2024-12-20T21:56:42Z |
| publishDate | 2013-12-01 |
| publisher | National Centre of Excellence in Analytical Chemsitry |
| record_format | Article |
| series | Pakistan Journal of Analytical & Environmental Chemistry |
| spelling | doaj.art-de3e0ac4db6e48ffa7012381ba1bf2302022-12-21T19:25:27ZengNational Centre of Excellence in Analytical ChemsitryPakistan Journal of Analytical & Environmental Chemistry1996-918X2221-52552013-12-011423843Determination of Tapentadol Hydrochloride in Tablets by Three New Validated Spectrophotometric MethodsDeepti Jain0Pawan Kumar Basniwal1School of Pharmaceutical Sciences, Rajiv Gandhi Technological University, Bhopal – 462 033, Madhya Pradesh, IndiaLBS College of Pharmacy, Jaipur – 302 004, Rajasthan, IndiaThree UV spectrophotometric methods viz. linear regression equation (LRE), standard absorptivity (SA) and first order derivative (FOD) method were developed and validated according to ICH guideline. The methods were linear in the range of 10-50 μg/mL and validated methods were successfully applied for determination of tapentadol hydrochloride content in tablet dosage forms in the range of 100.42-100.64%, 100.31-100.54% and 100.10-100.59%, respectively. The standard deviation for all the methods was found to be less than one unit (0.45-0.83). The validated spectrophotometric methods may be successfully applied for assay, dissolution studies, bio-equivalence studies as well as routine analysis in pharmaceutical industries.http://ceacsu.edu.pk/PDF%20file/Volume%2014%20No%202/38-43-PJAEC-25062013-18%5B1%5D.pdf |
| spellingShingle | Deepti Jain Pawan Kumar Basniwal Determination of Tapentadol Hydrochloride in Tablets by Three New Validated Spectrophotometric Methods Pakistan Journal of Analytical & Environmental Chemistry |
| title | Determination of Tapentadol Hydrochloride in Tablets by Three New Validated Spectrophotometric Methods |
| title_full | Determination of Tapentadol Hydrochloride in Tablets by Three New Validated Spectrophotometric Methods |
| title_fullStr | Determination of Tapentadol Hydrochloride in Tablets by Three New Validated Spectrophotometric Methods |
| title_full_unstemmed | Determination of Tapentadol Hydrochloride in Tablets by Three New Validated Spectrophotometric Methods |
| title_short | Determination of Tapentadol Hydrochloride in Tablets by Three New Validated Spectrophotometric Methods |
| title_sort | determination of tapentadol hydrochloride in tablets by three new validated spectrophotometric methods |
| url | http://ceacsu.edu.pk/PDF%20file/Volume%2014%20No%202/38-43-PJAEC-25062013-18%5B1%5D.pdf |
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