Resveratrol Protects against Cerebral Ischemic Injury via Restraining Lipid Peroxidation, Transition Elements, and Toxic Metal Levels, but Enhancing Anti-Oxidant Activity
Cerebral ischemia is related to increased oxidative stress. Resveratrol displays anti-oxidant and anti-inflammatory properties. The transition elements iron (Fe) and copper (Cu) are indispensable for the brain but overload is deleterious to brain function. Aluminum (Al) and arsenic (As) are toxic me...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/10/1515 |
| _version_ | 1797515532448038912 |
|---|---|
| author | Ming-Cheng Lin Chien-Chi Liu Yu-Chen Lin Chin-Sheng Liao |
| author_facet | Ming-Cheng Lin Chien-Chi Liu Yu-Chen Lin Chin-Sheng Liao |
| author_sort | Ming-Cheng Lin |
| collection | DOAJ |
| description | Cerebral ischemia is related to increased oxidative stress. Resveratrol displays anti-oxidant and anti-inflammatory properties. The transition elements iron (Fe) and copper (Cu) are indispensable for the brain but overload is deleterious to brain function. Aluminum (Al) and arsenic (As) are toxic metals that seriously threaten brain health. This study was conducted to elucidate the correlation of the neuroprotective mechanism of resveratrol to protect cerebral ischemic damage with modulation of the levels of lipid peroxidation, anti-oxidants, transition elements, and toxic metals. Experimentally, 20 mg/kg of resveratrol was given once daily for 10 days. The cerebral ischemic operation was performed via occlusion of the right common carotid artery together with the right middle cerebral artery for 60 min followed by homogenization of the brain cortex and collection of supernatants for biochemical analysis. In the ligation group, levels of malondialdehyde, Fe, Cu, Al, and As increased but those of the anti-oxidants superoxide dismutase and catalase decreased. Pretreating rats with resveratrol before ischemia significantly reversed these effects. Our findings highlight the association of overload of Fe, Cu, As, and Al with the pathophysiology of cerebral ischemia. In conclusion, resveratrol protects against cerebral ischemic injury via restraining lipid peroxidation, transition elements, and toxic metals, but increasing anti-oxidant activity. |
| first_indexed | 2024-03-10T06:46:45Z |
| format | Article |
| id | doaj.art-de3e2a8b3ce044a0af208462c57bd477 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T06:46:45Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-de3e2a8b3ce044a0af208462c57bd4772023-11-22T17:15:07ZengMDPI AGAntioxidants2076-39212021-09-011010151510.3390/antiox10101515Resveratrol Protects against Cerebral Ischemic Injury via Restraining Lipid Peroxidation, Transition Elements, and Toxic Metal Levels, but Enhancing Anti-Oxidant ActivityMing-Cheng Lin0Chien-Chi Liu1Yu-Chen Lin2Chin-Sheng Liao3Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 406053, TaiwanDepartment of Nursing, National Taichung University of Science and Technology, Taichung 404336, TaiwanDepartment of Medicine, Chung Shan Medical University, Taichung 402306, TaiwanLaboratory Department, Chung-Kang Branch, Cheng-Ching General Hospital, Taichung 407211, TaiwanCerebral ischemia is related to increased oxidative stress. Resveratrol displays anti-oxidant and anti-inflammatory properties. The transition elements iron (Fe) and copper (Cu) are indispensable for the brain but overload is deleterious to brain function. Aluminum (Al) and arsenic (As) are toxic metals that seriously threaten brain health. This study was conducted to elucidate the correlation of the neuroprotective mechanism of resveratrol to protect cerebral ischemic damage with modulation of the levels of lipid peroxidation, anti-oxidants, transition elements, and toxic metals. Experimentally, 20 mg/kg of resveratrol was given once daily for 10 days. The cerebral ischemic operation was performed via occlusion of the right common carotid artery together with the right middle cerebral artery for 60 min followed by homogenization of the brain cortex and collection of supernatants for biochemical analysis. In the ligation group, levels of malondialdehyde, Fe, Cu, Al, and As increased but those of the anti-oxidants superoxide dismutase and catalase decreased. Pretreating rats with resveratrol before ischemia significantly reversed these effects. Our findings highlight the association of overload of Fe, Cu, As, and Al with the pathophysiology of cerebral ischemia. In conclusion, resveratrol protects against cerebral ischemic injury via restraining lipid peroxidation, transition elements, and toxic metals, but increasing anti-oxidant activity.https://www.mdpi.com/2076-3921/10/10/1515resveratrolcerebral ischemiatransition elementoxidative stresstoxic metals |
| spellingShingle | Ming-Cheng Lin Chien-Chi Liu Yu-Chen Lin Chin-Sheng Liao Resveratrol Protects against Cerebral Ischemic Injury via Restraining Lipid Peroxidation, Transition Elements, and Toxic Metal Levels, but Enhancing Anti-Oxidant Activity Antioxidants resveratrol cerebral ischemia transition element oxidative stress toxic metals |
| title | Resveratrol Protects against Cerebral Ischemic Injury via Restraining Lipid Peroxidation, Transition Elements, and Toxic Metal Levels, but Enhancing Anti-Oxidant Activity |
| title_full | Resveratrol Protects against Cerebral Ischemic Injury via Restraining Lipid Peroxidation, Transition Elements, and Toxic Metal Levels, but Enhancing Anti-Oxidant Activity |
| title_fullStr | Resveratrol Protects against Cerebral Ischemic Injury via Restraining Lipid Peroxidation, Transition Elements, and Toxic Metal Levels, but Enhancing Anti-Oxidant Activity |
| title_full_unstemmed | Resveratrol Protects against Cerebral Ischemic Injury via Restraining Lipid Peroxidation, Transition Elements, and Toxic Metal Levels, but Enhancing Anti-Oxidant Activity |
| title_short | Resveratrol Protects against Cerebral Ischemic Injury via Restraining Lipid Peroxidation, Transition Elements, and Toxic Metal Levels, but Enhancing Anti-Oxidant Activity |
| title_sort | resveratrol protects against cerebral ischemic injury via restraining lipid peroxidation transition elements and toxic metal levels but enhancing anti oxidant activity |
| topic | resveratrol cerebral ischemia transition element oxidative stress toxic metals |
| url | https://www.mdpi.com/2076-3921/10/10/1515 |
| work_keys_str_mv | AT mingchenglin resveratrolprotectsagainstcerebralischemicinjuryviarestraininglipidperoxidationtransitionelementsandtoxicmetallevelsbutenhancingantioxidantactivity AT chienchiliu resveratrolprotectsagainstcerebralischemicinjuryviarestraininglipidperoxidationtransitionelementsandtoxicmetallevelsbutenhancingantioxidantactivity AT yuchenlin resveratrolprotectsagainstcerebralischemicinjuryviarestraininglipidperoxidationtransitionelementsandtoxicmetallevelsbutenhancingantioxidantactivity AT chinshengliao resveratrolprotectsagainstcerebralischemicinjuryviarestraininglipidperoxidationtransitionelementsandtoxicmetallevelsbutenhancingantioxidantactivity |