The Role of Microglia in the Development of Neurodegenerative Diseases
Microglia play an important role in the maintenance and neuroprotection of the central nervous system (CNS) by removing pathogens, damaged neurons, and plaques. Recent observations emphasize that the promotion and development of neurodegenerative diseases (NDs) are closely related to microglial acti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/10/1449 |
| _version_ | 1797515249320984576 |
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| author | Jae-Won Lee Wanjoo Chun Hee Jae Lee Seong-Man Kim Jae-Hong Min Doo-Young Kim Mun-Ock Kim Hyung Won Ryu Su Ui Lee |
| author_facet | Jae-Won Lee Wanjoo Chun Hee Jae Lee Seong-Man Kim Jae-Hong Min Doo-Young Kim Mun-Ock Kim Hyung Won Ryu Su Ui Lee |
| author_sort | Jae-Won Lee |
| collection | DOAJ |
| description | Microglia play an important role in the maintenance and neuroprotection of the central nervous system (CNS) by removing pathogens, damaged neurons, and plaques. Recent observations emphasize that the promotion and development of neurodegenerative diseases (NDs) are closely related to microglial activation. In this review, we summarize the contribution of microglial activation and its associated mechanisms in NDs, such as epilepsy, Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), based on recent observations. This review also briefly introduces experimental animal models of epilepsy, AD, PD, and HD. Thus, this review provides a better understanding of microglial functions in the development of NDs, suggesting that microglial targeting could be an effective therapeutic strategy for these diseases. |
| first_indexed | 2024-03-10T06:42:50Z |
| format | Article |
| id | doaj.art-de3ff1229f0543259be4140a9b8640fe |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T06:42:50Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-de3ff1229f0543259be4140a9b8640fe2023-11-22T17:32:05ZengMDPI AGBiomedicines2227-90592021-10-01910144910.3390/biomedicines9101449The Role of Microglia in the Development of Neurodegenerative DiseasesJae-Won Lee0Wanjoo Chun1Hee Jae Lee2Seong-Man Kim3Jae-Hong Min4Doo-Young Kim5Mun-Ock Kim6Hyung Won Ryu7Su Ui Lee8Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju 28116, KoreaDepartment of Pharmacology, College of Medicine, Kangwon National University, Chuncheon 24341, KoreaDepartment of Pharmacology, College of Medicine, Kangwon National University, Chuncheon 24341, KoreaNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju 28116, KoreaNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju 28116, KoreaNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju 28116, KoreaNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju 28116, KoreaNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju 28116, KoreaNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju 28116, KoreaMicroglia play an important role in the maintenance and neuroprotection of the central nervous system (CNS) by removing pathogens, damaged neurons, and plaques. Recent observations emphasize that the promotion and development of neurodegenerative diseases (NDs) are closely related to microglial activation. In this review, we summarize the contribution of microglial activation and its associated mechanisms in NDs, such as epilepsy, Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), based on recent observations. This review also briefly introduces experimental animal models of epilepsy, AD, PD, and HD. Thus, this review provides a better understanding of microglial functions in the development of NDs, suggesting that microglial targeting could be an effective therapeutic strategy for these diseases.https://www.mdpi.com/2227-9059/9/10/1449microglial activationinflammatory moleculesneuronal damageneurodegenerative diseases |
| spellingShingle | Jae-Won Lee Wanjoo Chun Hee Jae Lee Seong-Man Kim Jae-Hong Min Doo-Young Kim Mun-Ock Kim Hyung Won Ryu Su Ui Lee The Role of Microglia in the Development of Neurodegenerative Diseases Biomedicines microglial activation inflammatory molecules neuronal damage neurodegenerative diseases |
| title | The Role of Microglia in the Development of Neurodegenerative Diseases |
| title_full | The Role of Microglia in the Development of Neurodegenerative Diseases |
| title_fullStr | The Role of Microglia in the Development of Neurodegenerative Diseases |
| title_full_unstemmed | The Role of Microglia in the Development of Neurodegenerative Diseases |
| title_short | The Role of Microglia in the Development of Neurodegenerative Diseases |
| title_sort | role of microglia in the development of neurodegenerative diseases |
| topic | microglial activation inflammatory molecules neuronal damage neurodegenerative diseases |
| url | https://www.mdpi.com/2227-9059/9/10/1449 |
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