OX40 expression in hepatocellular carcinoma is associated with a distinct immune microenvironment, specific mutation signature, and poor prognosis

OX40 expression in hepatocellular carcinoma is associated with a distinct immune microenvironment, specific mutation signature, and poor prognosis

Immunotherapy's effect against hepatocellular carcinoma (HCC) is hampered by immunosuppressive mechanisms in the tumor microenvironment. We assessed the clinicopathologic and biologic relevance of OX40, a costimulatory molecular expressed by regulatory T cells (Tregs), in HCC. We analyzed the i...

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Bibliographic Details
Main Authors: Kunlin Xie, Lin Xu, Hao Wu, Haotian Liao, Lin Luo, Mingheng Liao, Jianping Gong, Yang Deng, Kefei Yuan, Hong Wu, Yong Zeng
Format: Article
Language:English
Published: Taylor & Francis Group 2018-04-01
Series:OncoImmunology
Subjects:
ox40
hepatocellular carcinoma
immune checkpoints
regulatory t cells
tumor microenvironment
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1404214

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