Evaluation of Serum and Urinary Levels of some Pteridine Pathway Components in Healthy Turkish Children
Neopterin, as a non-conjugated pteridine, is synthesized from guanosine triphosphate and its production is upregulated upon the activation of cellular immune response. Alterations of pteridines in body fluids are known to correlate well with existing diseases and stages, prognosis, clinical outcomes...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2012-02-01
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| Series: | Pteridines |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pteridines.2012.23.1.90 |
| _version_ | 1819031306084810752 |
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| author | Girgin Gözde Baydar Terken Fuchs Dietmar Sahin Gönül Özmert Elif Yurdakök Kadriye |
| author_facet | Girgin Gözde Baydar Terken Fuchs Dietmar Sahin Gönül Özmert Elif Yurdakök Kadriye |
| author_sort | Girgin Gözde |
| collection | DOAJ |
| description | Neopterin, as a non-conjugated pteridine, is synthesized from guanosine triphosphate and its production is upregulated upon the activation of cellular immune response. Alterations of pteridines in body fluids are known to correlate well with existing diseases and stages, prognosis, clinical outcomes and survival data. It is of advantage to have a pteridine database of healthy volunteers to determine normal values. Thereby, especially in children there is no detailed study on pteridine levels. The aim of this study is to initiate the establishment of pteridine database of healthy children in our country. Serum neopterin levels were analysed by enzyme-linked immunosorbent assay. Urinary neopterin and biopterin levels and serum kynurenine, tryptophan levels and kynurenine/tryptophan ratio as an estimate of tryptophan breakdown were assessed with high-pressure liquid chromatography in serum and urine samples of 55 children aged between 3 months and 10 years. The results were evaluated within the subgroups of different ages and sex. Pteridine pathway components were found to be higher in children compared to adults. Higher levels of pteridine pathway components observed within the first years of life may reflect the rapid maturation of the immune system, and environmental adaptation and/or insufficiency of defence systems. On the other hand, it may also relate to a higher frequency of infections not (yet) manifested clinically. |
| first_indexed | 2024-12-21T06:43:57Z |
| format | Article |
| id | doaj.art-de430b2fcc5847e7b8822f3afe1c81fd |
| institution | Directory Open Access Journal |
| issn | 0933-4807 2195-4720 |
| language | English |
| last_indexed | 2024-12-21T06:43:57Z |
| publishDate | 2012-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pteridines |
| spelling | doaj.art-de430b2fcc5847e7b8822f3afe1c81fd2022-12-21T19:12:39ZengDe GruyterPteridines0933-48072195-47202012-02-01231909510.1515/pteridines.2012.23.1.90Evaluation of Serum and Urinary Levels of some Pteridine Pathway Components in Healthy Turkish ChildrenGirgin Gözde0Baydar Terken1Fuchs Dietmar2Sahin Gönül3Özmert Elif4Yurdakök Kadriye5Hacettepe University, Faculty of Pharmacy, Toxicology Department Sihhiye, 90-06100 Ankara/TURKEY, Tel: +90 312 3052178, Fax: +90 312 3092958Hacettepe University, Faculty of Pharmacy, Toxicology Department, Ankara, TurkeyInnsbruck Medical University, Biocentre, Division of Biological Chemistry, Innsbruck, AustriaHacettepe University, Faculty of Pharmacy, Toxicology Department, Ankara, TurkeyHacettepe University, Faculty of Medicine, Department of Pediatrics, Social Pediatrics Unit, Ankara, TurkeyHacettepe University, Faculty of Medicine, Department of Pediatrics, Social Pediatrics Unit, Ankara, TurkeyNeopterin, as a non-conjugated pteridine, is synthesized from guanosine triphosphate and its production is upregulated upon the activation of cellular immune response. Alterations of pteridines in body fluids are known to correlate well with existing diseases and stages, prognosis, clinical outcomes and survival data. It is of advantage to have a pteridine database of healthy volunteers to determine normal values. Thereby, especially in children there is no detailed study on pteridine levels. The aim of this study is to initiate the establishment of pteridine database of healthy children in our country. Serum neopterin levels were analysed by enzyme-linked immunosorbent assay. Urinary neopterin and biopterin levels and serum kynurenine, tryptophan levels and kynurenine/tryptophan ratio as an estimate of tryptophan breakdown were assessed with high-pressure liquid chromatography in serum and urine samples of 55 children aged between 3 months and 10 years. The results were evaluated within the subgroups of different ages and sex. Pteridine pathway components were found to be higher in children compared to adults. Higher levels of pteridine pathway components observed within the first years of life may reflect the rapid maturation of the immune system, and environmental adaptation and/or insufficiency of defence systems. On the other hand, it may also relate to a higher frequency of infections not (yet) manifested clinically.https://doi.org/10.1515/pteridines.2012.23.1.90pteridinesneopterinbiopterintryptophankynureninechildren |
| spellingShingle | Girgin Gözde Baydar Terken Fuchs Dietmar Sahin Gönül Özmert Elif Yurdakök Kadriye Evaluation of Serum and Urinary Levels of some Pteridine Pathway Components in Healthy Turkish Children Pteridines pteridines neopterin biopterin tryptophan kynurenine children |
| title | Evaluation of Serum and Urinary Levels of some Pteridine Pathway Components in Healthy Turkish Children |
| title_full | Evaluation of Serum and Urinary Levels of some Pteridine Pathway Components in Healthy Turkish Children |
| title_fullStr | Evaluation of Serum and Urinary Levels of some Pteridine Pathway Components in Healthy Turkish Children |
| title_full_unstemmed | Evaluation of Serum and Urinary Levels of some Pteridine Pathway Components in Healthy Turkish Children |
| title_short | Evaluation of Serum and Urinary Levels of some Pteridine Pathway Components in Healthy Turkish Children |
| title_sort | evaluation of serum and urinary levels of some pteridine pathway components in healthy turkish children |
| topic | pteridines neopterin biopterin tryptophan kynurenine children |
| url | https://doi.org/10.1515/pteridines.2012.23.1.90 |
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