Clinical and Prognostic Significance of the Eighth Edition Oral Cancer Staging System
Objectives: The most notable changes in the eighth edition of the AJCC Cancer Staging System include incorporating the depth of invasion (DOI) into T staging and extranodal extension (ENE) into N staging. In this study, we retrospectively assessed the prognostic and clinical implications of the eigh...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/19/4632 |
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| author | Yasmin Ghantous Aysar Nashef David Sidransky Murad Abdelraziq Kutaiba Alkeesh Shareef Araidy Wayne Koch Mariana Brait Imad Abu El-Naaj |
| author_facet | Yasmin Ghantous Aysar Nashef David Sidransky Murad Abdelraziq Kutaiba Alkeesh Shareef Araidy Wayne Koch Mariana Brait Imad Abu El-Naaj |
| author_sort | Yasmin Ghantous |
| collection | DOAJ |
| description | Objectives: The most notable changes in the eighth edition of the AJCC Cancer Staging System include incorporating the depth of invasion (DOI) into T staging and extranodal extension (ENE) into N staging. In this study, we retrospectively assessed the prognostic and clinical implications of the eighth TNM staging system. Materials and Methods: Patients with Oral Squamous Cell Carcinoma (OSCC) who were treated surgically between 2010 and 2017 were retrospectively reviewed. Tumors were first staged according to the seventh edition and restaged using the eighth edition. The prognostic value of the resultant upstaging was evaluated. Results: Integrating the DOI into the T classification resulted in the upstaging of 65 patients, whereas incorporating ENE into the N staging resulted in the upstaging of 18 patients <i>(p</i> < 0.001). Upstaging due to DOI integration had no significant effect on OS or DSS (<i>p</i> > 0.05). Conclusion: Our results demonstrate the importance of incorporating ENE into nodal staging and considering adjuvant therapy when ENE is present. |
| first_indexed | 2024-03-09T21:59:04Z |
| format | Article |
| id | doaj.art-de433c91d2a649119b032002de39faf0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T21:59:04Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-de433c91d2a649119b032002de39faf02023-11-23T19:54:00ZengMDPI AGCancers2072-66942022-09-011419463210.3390/cancers14194632Clinical and Prognostic Significance of the Eighth Edition Oral Cancer Staging SystemYasmin Ghantous0Aysar Nashef1David Sidransky2Murad Abdelraziq3Kutaiba Alkeesh4Shareef Araidy5Wayne Koch6Mariana Brait7Imad Abu El-Naaj8Department of Oral and Maxillofacial Surgery, Baruch Padeh Medical Center, Faculty of Medicine, Bar Ilan University, Ramat Gan 15208, IsraelDepartment of Oral and Maxillofacial Surgery, Baruch Padeh Medical Center, Faculty of Medicine, Bar Ilan University, Ramat Gan 15208, IsraelDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Oral and Maxillofacial Surgery, Baruch Padeh Medical Center, Faculty of Medicine, Bar Ilan University, Ramat Gan 15208, IsraelDepartment of Oral and Maxillofacial Surgery, Baruch Padeh Medical Center, Faculty of Medicine, Bar Ilan University, Ramat Gan 15208, IsraelDepartment of Oral and Maxillofacial Surgery, Baruch Padeh Medical Center, Faculty of Medicine, Bar Ilan University, Ramat Gan 15208, IsraelDepartment of Otolaryngology and Head & Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USADepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Oral and Maxillofacial Surgery, Baruch Padeh Medical Center, Faculty of Medicine, Bar Ilan University, Ramat Gan 15208, IsraelObjectives: The most notable changes in the eighth edition of the AJCC Cancer Staging System include incorporating the depth of invasion (DOI) into T staging and extranodal extension (ENE) into N staging. In this study, we retrospectively assessed the prognostic and clinical implications of the eighth TNM staging system. Materials and Methods: Patients with Oral Squamous Cell Carcinoma (OSCC) who were treated surgically between 2010 and 2017 were retrospectively reviewed. Tumors were first staged according to the seventh edition and restaged using the eighth edition. The prognostic value of the resultant upstaging was evaluated. Results: Integrating the DOI into the T classification resulted in the upstaging of 65 patients, whereas incorporating ENE into the N staging resulted in the upstaging of 18 patients <i>(p</i> < 0.001). Upstaging due to DOI integration had no significant effect on OS or DSS (<i>p</i> > 0.05). Conclusion: Our results demonstrate the importance of incorporating ENE into nodal staging and considering adjuvant therapy when ENE is present.https://www.mdpi.com/2072-6694/14/19/4632oral carcinomadepth of invasionENEprognosisadjuvant therapy |
| spellingShingle | Yasmin Ghantous Aysar Nashef David Sidransky Murad Abdelraziq Kutaiba Alkeesh Shareef Araidy Wayne Koch Mariana Brait Imad Abu El-Naaj Clinical and Prognostic Significance of the Eighth Edition Oral Cancer Staging System Cancers oral carcinoma depth of invasion ENE prognosis adjuvant therapy |
| title | Clinical and Prognostic Significance of the Eighth Edition Oral Cancer Staging System |
| title_full | Clinical and Prognostic Significance of the Eighth Edition Oral Cancer Staging System |
| title_fullStr | Clinical and Prognostic Significance of the Eighth Edition Oral Cancer Staging System |
| title_full_unstemmed | Clinical and Prognostic Significance of the Eighth Edition Oral Cancer Staging System |
| title_short | Clinical and Prognostic Significance of the Eighth Edition Oral Cancer Staging System |
| title_sort | clinical and prognostic significance of the eighth edition oral cancer staging system |
| topic | oral carcinoma depth of invasion ENE prognosis adjuvant therapy |
| url | https://www.mdpi.com/2072-6694/14/19/4632 |
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