Diuretics are Similar to Losartan on Echocardiographic Target-Organ Damage in Stage I Hypertension. PREVER-Treatment Study
Abstract Blood pressure (BP)-lowering therapy improves left ventricular (LV) parameters of hypertensive target-organ damage in stage II hypertension, but whether there is a drug-class difference in echocardiographic parameters in stage I hypertension patients is less often studied. In the PREVER tre...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cardiologia (SBC)
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| Series: | Arquivos Brasileiros de Cardiologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019000100087&lng=en&tlng=en |
| _version_ | 1819059969412038656 |
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| author | Carolina Bertoluci Murilo Foppa Angela Barreto Santiago Santos Sandra C. Fuchs Flávio Danni Fuchs |
| author_facet | Carolina Bertoluci Murilo Foppa Angela Barreto Santiago Santos Sandra C. Fuchs Flávio Danni Fuchs |
| author_sort | Carolina Bertoluci |
| collection | DOAJ |
| description | Abstract Blood pressure (BP)-lowering therapy improves left ventricular (LV) parameters of hypertensive target-organ damage in stage II hypertension, but whether there is a drug-class difference in echocardiographic parameters in stage I hypertension patients is less often studied. In the PREVER treatment study, where individuals with stage I hypertension were randomized for treatment with diuretics (chlorthalidone/amiloride) or losartan, 110 participants accepted to participate in a sub-study, where two-dimensional echocardiograms were performed at baseline and after 18 months of antihypertensive treatment. As in the general study, systolic BP reduction was similar with diuretics or with losartan. Echocardiographic parameters showed small but significant changes in both treatment groups, with a favorable LV remodeling with antihypertensive treatment for 18 months when target blood pressure was achieved either with chlorthalidone/amiloride or with losartan as the initial treatment strategy. In conclusion, even in stage I hypertension, blood pressure reduction is associated with improvement in echocardiographic parameters, either with diuretics or losartan as first-drug regimens. |
| first_indexed | 2024-12-21T14:19:32Z |
| format | Article |
| id | doaj.art-de43ecae72754fcfa61a90115e84a5b6 |
| institution | Directory Open Access Journal |
| issn | 1678-4170 |
| language | English |
| last_indexed | 2024-12-21T14:19:32Z |
| publisher | Sociedade Brasileira de Cardiologia (SBC) |
| record_format | Article |
| series | Arquivos Brasileiros de Cardiologia |
| spelling | doaj.art-de43ecae72754fcfa61a90115e84a5b62022-12-21T19:00:50ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia1678-41701121879010.5935/abc.20180249S0066-782X2019000100087Diuretics are Similar to Losartan on Echocardiographic Target-Organ Damage in Stage I Hypertension. PREVER-Treatment StudyCarolina BertoluciMurilo FoppaAngela Barreto Santiago SantosSandra C. FuchsFlávio Danni FuchsAbstract Blood pressure (BP)-lowering therapy improves left ventricular (LV) parameters of hypertensive target-organ damage in stage II hypertension, but whether there is a drug-class difference in echocardiographic parameters in stage I hypertension patients is less often studied. In the PREVER treatment study, where individuals with stage I hypertension were randomized for treatment with diuretics (chlorthalidone/amiloride) or losartan, 110 participants accepted to participate in a sub-study, where two-dimensional echocardiograms were performed at baseline and after 18 months of antihypertensive treatment. As in the general study, systolic BP reduction was similar with diuretics or with losartan. Echocardiographic parameters showed small but significant changes in both treatment groups, with a favorable LV remodeling with antihypertensive treatment for 18 months when target blood pressure was achieved either with chlorthalidone/amiloride or with losartan as the initial treatment strategy. In conclusion, even in stage I hypertension, blood pressure reduction is associated with improvement in echocardiographic parameters, either with diuretics or losartan as first-drug regimens.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019000100087&lng=en&tlng=enAngiotensin-Converting Enzyme InhibitorsAnihypertensive AgentsAntihypertensive Agents/therapyBlood PressureHypertension/complicationsHypertension/therapyCalcium ChannelEchocardiography |
| spellingShingle | Carolina Bertoluci Murilo Foppa Angela Barreto Santiago Santos Sandra C. Fuchs Flávio Danni Fuchs Diuretics are Similar to Losartan on Echocardiographic Target-Organ Damage in Stage I Hypertension. PREVER-Treatment Study Arquivos Brasileiros de Cardiologia Angiotensin-Converting Enzyme Inhibitors Anihypertensive Agents Antihypertensive Agents/therapy Blood Pressure Hypertension/complications Hypertension/therapy Calcium Channel Echocardiography |
| title | Diuretics are Similar to Losartan on Echocardiographic Target-Organ Damage in Stage I Hypertension. PREVER-Treatment Study |
| title_full | Diuretics are Similar to Losartan on Echocardiographic Target-Organ Damage in Stage I Hypertension. PREVER-Treatment Study |
| title_fullStr | Diuretics are Similar to Losartan on Echocardiographic Target-Organ Damage in Stage I Hypertension. PREVER-Treatment Study |
| title_full_unstemmed | Diuretics are Similar to Losartan on Echocardiographic Target-Organ Damage in Stage I Hypertension. PREVER-Treatment Study |
| title_short | Diuretics are Similar to Losartan on Echocardiographic Target-Organ Damage in Stage I Hypertension. PREVER-Treatment Study |
| title_sort | diuretics are similar to losartan on echocardiographic target organ damage in stage i hypertension prever treatment study |
| topic | Angiotensin-Converting Enzyme Inhibitors Anihypertensive Agents Antihypertensive Agents/therapy Blood Pressure Hypertension/complications Hypertension/therapy Calcium Channel Echocardiography |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019000100087&lng=en&tlng=en |
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