Prevalence of homocysteinemia and effect of vitamin supplementation in retinal vein occlusion
Objective The objective of this study was to determine the prevalence of homocysteinemia in patients with retinal vein occlusion (RVO). We investigated the association of B complex vitamin (BCV) and multivitamin (MVI) supplementation on homocysteine levels in RVO patients.Methods and analysis This c...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-11-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/7/1/e001139.full |
| _version_ | 1811328234620452864 |
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| author | Amro A Harb Maxwell Levi Andrew Trippiedi Sophia Rodriguez Nicholas Vianna Lisa M Higgins Lauren Kallina Lee Angioletti Justin Gutman Patrick M Higgins |
| author_facet | Amro A Harb Maxwell Levi Andrew Trippiedi Sophia Rodriguez Nicholas Vianna Lisa M Higgins Lauren Kallina Lee Angioletti Justin Gutman Patrick M Higgins |
| author_sort | Amro A Harb |
| collection | DOAJ |
| description | Objective The objective of this study was to determine the prevalence of homocysteinemia in patients with retinal vein occlusion (RVO). We investigated the association of B complex vitamin (BCV) and multivitamin (MVI) supplementation on homocysteine levels in RVO patients.Methods and analysis This cross-sectional study occurred at the Retina Center of New Jersey. We investigated 312 patients diagnosed with RVO between 2011 and 2019. Homocysteine levels were measured on diagnosis of RVO and 4–8 weeks after, following recommended daily supplementation with BCV, MVI or combination MVI+BCV.Results The median patient age was 71.00, IQR (61.00, 78.25), with 164 (52.6%) being women. Prevalence of homocysteinemia (>13 µmol/L) was 150 of 312 (48.1%), with a median baseline homocysteine level of 12.80 (10.17, 15.90) µmol/L. The follow-up cohort, 105 patients, demonstrated significant reduction in median homocysteine levels from 14.50 (12.30, 17.90) to 10.70 (9.30, 13.50) µmol/L following vitamin supplementation. Multivariate analysis found having baseline homocysteinemia was significantly associated with at least 25% reduction in homocysteine following vitamin supplementation.Conclusions In this study, 48.1% of patients with RVO had elevated homocysteine (>13 µmol/L). Supplementation with BCV or MVI+BCV was associated with a significant reduction in homocysteine from 14.50 (12.30, 17.90) to 10.70 (9.30, 13.50) µmol/L. |
| first_indexed | 2024-04-13T15:21:36Z |
| format | Article |
| id | doaj.art-de4421c6d2f8448dbc534d9f558ada4a |
| institution | Directory Open Access Journal |
| issn | 2397-3269 |
| language | English |
| last_indexed | 2024-04-13T15:21:36Z |
| publishDate | 2022-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj.art-de4421c6d2f8448dbc534d9f558ada4a2022-12-22T02:41:39ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692022-11-017110.1136/bmjophth-2022-001139Prevalence of homocysteinemia and effect of vitamin supplementation in retinal vein occlusionAmro A Harb0Maxwell Levi1Andrew Trippiedi2Sophia Rodriguez3Nicholas Vianna4Lisa M Higgins5Lauren Kallina6Lee Angioletti7Justin Gutman8Patrick M Higgins9Columbia University Vagelos College of Physicians and Surgeons, New York City, New York, USAOphthalmology, Retina Center of New Jersey, Bloomfield, New Jersey, USAOphthalmology, Retina Center of New Jersey, Bloomfield, New Jersey, USAOphthalmology, Retina Center of New Jersey, Bloomfield, New Jersey, USAOphthalmology, Retina Center of New Jersey, Bloomfield, New Jersey, USAOphthalmology, Retina Center of New Jersey, Bloomfield, New Jersey, USAOphthalmology, Retina Center of New Jersey, Bloomfield, New Jersey, USAOphthalmology, Retina Center of New Jersey, Bloomfield, New Jersey, USAOphthalmology, Retina Center of New Jersey, Bloomfield, New Jersey, USAOphthalmology, Retina Center of New Jersey, Bloomfield, New Jersey, USAObjective The objective of this study was to determine the prevalence of homocysteinemia in patients with retinal vein occlusion (RVO). We investigated the association of B complex vitamin (BCV) and multivitamin (MVI) supplementation on homocysteine levels in RVO patients.Methods and analysis This cross-sectional study occurred at the Retina Center of New Jersey. We investigated 312 patients diagnosed with RVO between 2011 and 2019. Homocysteine levels were measured on diagnosis of RVO and 4–8 weeks after, following recommended daily supplementation with BCV, MVI or combination MVI+BCV.Results The median patient age was 71.00, IQR (61.00, 78.25), with 164 (52.6%) being women. Prevalence of homocysteinemia (>13 µmol/L) was 150 of 312 (48.1%), with a median baseline homocysteine level of 12.80 (10.17, 15.90) µmol/L. The follow-up cohort, 105 patients, demonstrated significant reduction in median homocysteine levels from 14.50 (12.30, 17.90) to 10.70 (9.30, 13.50) µmol/L following vitamin supplementation. Multivariate analysis found having baseline homocysteinemia was significantly associated with at least 25% reduction in homocysteine following vitamin supplementation.Conclusions In this study, 48.1% of patients with RVO had elevated homocysteine (>13 µmol/L). Supplementation with BCV or MVI+BCV was associated with a significant reduction in homocysteine from 14.50 (12.30, 17.90) to 10.70 (9.30, 13.50) µmol/L.https://bmjophth.bmj.com/content/7/1/e001139.full |
| spellingShingle | Amro A Harb Maxwell Levi Andrew Trippiedi Sophia Rodriguez Nicholas Vianna Lisa M Higgins Lauren Kallina Lee Angioletti Justin Gutman Patrick M Higgins Prevalence of homocysteinemia and effect of vitamin supplementation in retinal vein occlusion BMJ Open Ophthalmology |
| title | Prevalence of homocysteinemia and effect of vitamin supplementation in retinal vein occlusion |
| title_full | Prevalence of homocysteinemia and effect of vitamin supplementation in retinal vein occlusion |
| title_fullStr | Prevalence of homocysteinemia and effect of vitamin supplementation in retinal vein occlusion |
| title_full_unstemmed | Prevalence of homocysteinemia and effect of vitamin supplementation in retinal vein occlusion |
| title_short | Prevalence of homocysteinemia and effect of vitamin supplementation in retinal vein occlusion |
| title_sort | prevalence of homocysteinemia and effect of vitamin supplementation in retinal vein occlusion |
| url | https://bmjophth.bmj.com/content/7/1/e001139.full |
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