Correlation of Vitamin D3 Levels and SCORAD Index in Atopic Dermatits: A Case Control Study
Introduction: Atopic Dermatitis (AD) is a common chronic inflammatory condition characterized clinically by pruritus and eczematous lesions. An inverse relationship has been suggested between serum 25-hydroxyvitamin D concentration and severity of atopic dermatitis. Aim: We carried out this con...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/10223/27188_CE(RA1)_F(T)_PF1(SS_RO)_PFA(NC).pdf |
| Summary: | Introduction: Atopic Dermatitis (AD) is a common chronic
inflammatory condition characterized clinically by pruritus and
eczematous lesions. An inverse relationship has been suggested
between serum 25-hydroxyvitamin D concentration and severity
of atopic dermatitis.
Aim: We carried out this controlled cross- sectional study to
evaluate the association between the serum vitamin D3
levels and
SCORAD index.
Materials and Methods: For this study, 40 patients with clinical
diagnosis of AD based on UK diagnostic criteria were enrolled and
40 patients with minor ailments like superficial bacterial, fungal
or viral infections and not suffering from atopic dermatitis were
taken as controls. Salient presentations were recorded in a preset proforma. Serum 25-hydroxyvitamin D levels were determined
through Sandwich-ELISA technique. SCORAD (Scoring AD) index
was used to evaluate the severity of the disease.
Results: Mean value of serum 25-hydroxyvitamin D levels
in cases was 30.38 nmol/l whereas in controls, it was 53.46
nmol/l. The decrease in serum levels in cases was statistically
highly significant (p-value <0.001). Mean±S.D of serum vitamin
D levels in mild disease was 33.29±5.89 nmol/l, in moderate
disease was 31.52±6.04 nmol/l and in severe form of disease was
21.24±3.17nmol/l. The correlation between SCORAD and serum
25-hydroxyvitamin D levels was also statistically significant.
Conclusion: The data suggests an inverse relationship between
serum levels of vitamin D3
and the SCORAD Index. |
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| ISSN: | 2249-782X 0973-709X |