Gene constellation of influenza A virus reassortants with high growth phenotype prepared as seed candidates for vaccine production.

Gene constellation of influenza A virus reassortants with high growth phenotype prepared as seed candidates for vaccine production.

BACKGROUND: Influenza A virus vaccines undergo yearly reformulations due to the antigenic variability of the virus caused by antigenic drift and shift. It is critical to the vaccine manufacturing process to obtain influenza A seed virus that is antigenically identical to circulating wild type (wt) v...

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Bibliographic Details
Main Authors: Andrew A Fulvini, Manojkumar Ramanunninair, Jianhua Le, Barbara A Pokorny, Jennifer Minieri Arroyo, Jeanmarie Silverman, Rene Devis, Doris Bucher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3113853?pdf=render

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