Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats

Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats

The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated in human genetic pain disorders and is a validated pain target. However, targeting this channel directly has failed, and an indirect approach...

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Bibliographic Details
Main Authors: Jiahe Li, Harrison J. Stratton, Sabina A. Lorca, Peter M. Grace, Rajesh Khanna
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Channels
Subjects:
chronic pain
nav1.7
crmp2
sumoylation
nociceptor
ubc9
Online Access:http://dx.doi.org/10.1080/19336950.2021.2023383

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