The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion
Recurrent spontaneous abortion (RSA) is defined as the loss of two or more consecutive intrauterine pregnancies that are clinically established early in pregnancy. To date, the etiology and underlying mechanisms of RSA remain unclear. It is widely thought that the impairment of decidualization is in...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.862180/full |
| _version_ | 1818364459411832832 |
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| author | Rong-hui Zhu Fang-fang Dai Dong-yong Yang Shi-yi Liu Ya-jing Zheng Ma-li Wu Zhi-min Deng Zi-tao Wang Yu-wei Zhang Wei Tan Zhi-dian Li Juan He Xiao Yang Xiao Yang Min Hu Yan-xiang Cheng |
| author_facet | Rong-hui Zhu Fang-fang Dai Dong-yong Yang Shi-yi Liu Ya-jing Zheng Ma-li Wu Zhi-min Deng Zi-tao Wang Yu-wei Zhang Wei Tan Zhi-dian Li Juan He Xiao Yang Xiao Yang Min Hu Yan-xiang Cheng |
| author_sort | Rong-hui Zhu |
| collection | DOAJ |
| description | Recurrent spontaneous abortion (RSA) is defined as the loss of two or more consecutive intrauterine pregnancies that are clinically established early in pregnancy. To date, the etiology and underlying mechanisms of RSA remain unclear. It is widely thought that the impairment of decidualization is inclined to induce subsequent pregnancy failure and leads to the dysregulation of extra-villous trophoblast invasion and proliferation through maternal–fetal cross talk. However, the mechanism of decidualization in RSA has yet to be understood. In our study, we demonstrate that decidual samples from RSA patients have significantly higher insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and lower TGF-β1 levels compared to healthy controls. In addition, the overexpression of IGF2BP3 in human endometrial stromal cells (hESCs) can lead to the impairment of decidualization in vitro-induced model and the abnormal cell cycle regulation. Furthermore, TGF-β1 and MMP9 levels were greatly increased after decidualization, whereas IGF2BP3 overexpression inhibited endometrial mesenchymal decidualization by downregulating TGF-β1, impeding maternal–fetal interface cytokine cross talk, and limiting the ability of trophoblast invasion. In conclusion, our investigation first demonstrates that abnormal elevation of IGF2BP3 in the pregnant endometrium leads to the impairment of decidualization and abnormal trophoblast invasion, thereby predisposing individuals to RSA. |
| first_indexed | 2024-12-13T22:04:42Z |
| format | Article |
| id | doaj.art-de4956f688144e79bdcbdb337ab937bf |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-13T22:04:42Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-de4956f688144e79bdcbdb337ab937bf2022-12-21T23:29:54ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-04-011010.3389/fcell.2022.862180862180The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous AbortionRong-hui Zhu0Fang-fang Dai1Dong-yong Yang2Shi-yi Liu3Ya-jing Zheng4Ma-li Wu5Zhi-min Deng6Zi-tao Wang7Yu-wei Zhang8Wei Tan9Zhi-dian Li10Juan He11Xiao Yang12Xiao Yang13Min Hu14Yan-xiang Cheng15Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Peking University People’s Hospital, Beijing, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, ChinaRecurrent spontaneous abortion (RSA) is defined as the loss of two or more consecutive intrauterine pregnancies that are clinically established early in pregnancy. To date, the etiology and underlying mechanisms of RSA remain unclear. It is widely thought that the impairment of decidualization is inclined to induce subsequent pregnancy failure and leads to the dysregulation of extra-villous trophoblast invasion and proliferation through maternal–fetal cross talk. However, the mechanism of decidualization in RSA has yet to be understood. In our study, we demonstrate that decidual samples from RSA patients have significantly higher insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and lower TGF-β1 levels compared to healthy controls. In addition, the overexpression of IGF2BP3 in human endometrial stromal cells (hESCs) can lead to the impairment of decidualization in vitro-induced model and the abnormal cell cycle regulation. Furthermore, TGF-β1 and MMP9 levels were greatly increased after decidualization, whereas IGF2BP3 overexpression inhibited endometrial mesenchymal decidualization by downregulating TGF-β1, impeding maternal–fetal interface cytokine cross talk, and limiting the ability of trophoblast invasion. In conclusion, our investigation first demonstrates that abnormal elevation of IGF2BP3 in the pregnant endometrium leads to the impairment of decidualization and abnormal trophoblast invasion, thereby predisposing individuals to RSA.https://www.frontiersin.org/articles/10.3389/fcell.2022.862180/fullrecurrent spontaneous abortiondecidualizationIGF2BP3TGF-β1maternal–fetal interface cross talk |
| spellingShingle | Rong-hui Zhu Fang-fang Dai Dong-yong Yang Shi-yi Liu Ya-jing Zheng Ma-li Wu Zhi-min Deng Zi-tao Wang Yu-wei Zhang Wei Tan Zhi-dian Li Juan He Xiao Yang Xiao Yang Min Hu Yan-xiang Cheng The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion Frontiers in Cell and Developmental Biology recurrent spontaneous abortion decidualization IGF2BP3 TGF-β1 maternal–fetal interface cross talk |
| title | The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion |
| title_full | The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion |
| title_fullStr | The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion |
| title_full_unstemmed | The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion |
| title_short | The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion |
| title_sort | mechanism of insulin like growth factor ii mrna binging protein 3 induce decidualization and maternal fetal interface cross talk by tgf β1 in recurrent spontaneous abortion |
| topic | recurrent spontaneous abortion decidualization IGF2BP3 TGF-β1 maternal–fetal interface cross talk |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.862180/full |
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