Non Hodgkin Lymphoma Among Children: Pathological Aspects and Diagnostic Challenges
Non-Hodgkin lymphoma (NHL) are common malignancies in children. Available data on clinico-pathological aspects of pediatric NHL in developping countries are limited and diagnostic approach appears more delicate with absence of molecular studies. The objectives of our study are: analyzing the patholo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-04-01
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| Series: | Clinical Pathology |
| Online Access: | https://doi.org/10.1177/2632010X221090156 |
| _version_ | 1828280494766161920 |
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| author | Sabrine Derqaoui Ismail Boujida Oussama Marbouh Lamiaa Rouas Laila Hessissen Najat Lamalmi |
| author_facet | Sabrine Derqaoui Ismail Boujida Oussama Marbouh Lamiaa Rouas Laila Hessissen Najat Lamalmi |
| author_sort | Sabrine Derqaoui |
| collection | DOAJ |
| description | Non-Hodgkin lymphoma (NHL) are common malignancies in children. Available data on clinico-pathological aspects of pediatric NHL in developping countries are limited and diagnostic approach appears more delicate with absence of molecular studies. The objectives of our study are: analyzing the pathological spectrum of NHL among children and highlighting challenges in the diagnosis including: limited biopsic material; unususal subtyptes, age group, or localization. We retrospectively analyzed clinico pathological characteristics of 101 NHL’s cases among children diagnosed in the Pediatric’s pathology unit over a period of 4 years There were 78 (77.2%) male and 23 (22.8%) female. The median age was 7.2 years. The most common histologic subtypes of NHL were Burkitt lymphoma in 65 patients (64.4% ); followed by lymphoblastic lymphoma in 22 patients, large B-cell lymphoma in 9 patients ( 8.9%); anaplastic T cell lymphoma in 3 patients; NOS mature T cell lymphoma and pediatric type follicular lympoma in 1 patient each. In conclusion, this study Morocco illustrates the pattern of distribution of NHL and emphasizes challenges in the diagnosis of these neoplasms. |
| first_indexed | 2024-04-13T08:00:40Z |
| format | Article |
| id | doaj.art-de49d8d37ab24a88b58c99611d34cba2 |
| institution | Directory Open Access Journal |
| issn | 2632-010X |
| language | English |
| last_indexed | 2024-04-13T08:00:40Z |
| publishDate | 2022-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Pathology |
| spelling | doaj.art-de49d8d37ab24a88b58c99611d34cba22022-12-22T02:55:18ZengSAGE PublishingClinical Pathology2632-010X2022-04-011510.1177/2632010X221090156Non Hodgkin Lymphoma Among Children: Pathological Aspects and Diagnostic ChallengesSabrine Derqaoui0Ismail Boujida1Oussama Marbouh2Lamiaa Rouas3Laila Hessissen4Najat Lamalmi5Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, Rabat, MoroccoFaculty of Medicine and Pharmacy of Rabat, Mohamed V University, Rabat, MoroccoDepartment of Pediatric Surgery A, Children’s Hospital Ibn Sina University Hospital, Rabat, MoroccoFaculty of Medicine and Pharmacy of Rabat, Mohamed V University, Rabat, MoroccoCenter of Pediatric Hematology and Oncology, Children’s Hospital Ibn Sina University Hospital, Rabat, MoroccoFaculty of Medicine and Pharmacy of Rabat, Mohamed V University, Rabat, MoroccoNon-Hodgkin lymphoma (NHL) are common malignancies in children. Available data on clinico-pathological aspects of pediatric NHL in developping countries are limited and diagnostic approach appears more delicate with absence of molecular studies. The objectives of our study are: analyzing the pathological spectrum of NHL among children and highlighting challenges in the diagnosis including: limited biopsic material; unususal subtyptes, age group, or localization. We retrospectively analyzed clinico pathological characteristics of 101 NHL’s cases among children diagnosed in the Pediatric’s pathology unit over a period of 4 years There were 78 (77.2%) male and 23 (22.8%) female. The median age was 7.2 years. The most common histologic subtypes of NHL were Burkitt lymphoma in 65 patients (64.4% ); followed by lymphoblastic lymphoma in 22 patients, large B-cell lymphoma in 9 patients ( 8.9%); anaplastic T cell lymphoma in 3 patients; NOS mature T cell lymphoma and pediatric type follicular lympoma in 1 patient each. In conclusion, this study Morocco illustrates the pattern of distribution of NHL and emphasizes challenges in the diagnosis of these neoplasms.https://doi.org/10.1177/2632010X221090156 |
| spellingShingle | Sabrine Derqaoui Ismail Boujida Oussama Marbouh Lamiaa Rouas Laila Hessissen Najat Lamalmi Non Hodgkin Lymphoma Among Children: Pathological Aspects and Diagnostic Challenges Clinical Pathology |
| title | Non Hodgkin Lymphoma Among Children: Pathological Aspects and Diagnostic Challenges |
| title_full | Non Hodgkin Lymphoma Among Children: Pathological Aspects and Diagnostic Challenges |
| title_fullStr | Non Hodgkin Lymphoma Among Children: Pathological Aspects and Diagnostic Challenges |
| title_full_unstemmed | Non Hodgkin Lymphoma Among Children: Pathological Aspects and Diagnostic Challenges |
| title_short | Non Hodgkin Lymphoma Among Children: Pathological Aspects and Diagnostic Challenges |
| title_sort | non hodgkin lymphoma among children pathological aspects and diagnostic challenges |
| url | https://doi.org/10.1177/2632010X221090156 |
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