Dilated cardiomyopathy and hypothyroidism associated with pegylated interferon and ribavirin treatment for chronic hepatitis C: case report and literature review
Pegylated interferon alpha (Peg IFN-α) in combination with ribavirin is the backbone of treatment in chronic hepatitis C (CHC). Cardiotoxicity due to interferon therapy is rare. The most frequent cardiovascular complications are arrhythmias and ischemic manifestations. Cardiomyopathy is extremely ra...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-01-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867013002286 |
| _version_ | 1818145569783152640 |
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| author | Wenxue Zhao Fanpu Ji Shanshan Yu Zongfang Li Hong Deng |
| author_facet | Wenxue Zhao Fanpu Ji Shanshan Yu Zongfang Li Hong Deng |
| author_sort | Wenxue Zhao |
| collection | DOAJ |
| description | Pegylated interferon alpha (Peg IFN-α) in combination with ribavirin is the backbone of treatment in chronic hepatitis C (CHC). Cardiotoxicity due to interferon therapy is rare. The most frequent cardiovascular complications are arrhythmias and ischemic manifestations. Cardiomyopathy is extremely rare but can be life threatening. We present the case of a 41-year-old female patient with CHC in whom Peg IFN-α induced dilated cardiomyopathy and hypothyroidism. Chest radiography showed an enlarged and globular cardiac silhouette and pulmonary congestion. Echocardiography showed decreased left ventricular systolic function with an ejection fraction of 32% and fractional shortening of 15%. Cardiomyopathy had a complete remission after cessation of antiviral therapy with short-term heart failure medications and supportive care. Then we review the current literature about interferon induced cardiomyopathy in patients with HCV infection, as well as share our clinical experience in diagnosing and managing this rare complication. Keywords: Pegylated interferon, Adverse drug reaction, Cardiotoxicity, Thyroid dysfunction |
| first_indexed | 2024-12-11T12:05:33Z |
| format | Article |
| id | doaj.art-de4ba90be7f7405ea08e90e298bd601f |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-11T12:05:33Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-de4ba90be7f7405ea08e90e298bd601f2022-12-22T01:07:56ZengElsevierBrazilian Journal of Infectious Diseases1413-86702014-01-01181110113S1413-86702014000100110Dilated cardiomyopathy and hypothyroidism associated with pegylated interferon and ribavirin treatment for chronic hepatitis C: case report and literature reviewWenxue Zhao0Fanpu Ji1Shanshan Yu2Zongfang Li3Hong Deng4Department of Infectious Disease, The Second Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Infectious Disease, The Second Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, China; Corresponding author at: Department of Infectious Disease, The Second Affiliated hospital, College of Medicine, Xi’an Jiaotong University, 157 Xi Wu Road, Xi’an, Shaanxi 710004, People's Republic of China.Department of Ultrasound Medicine, The Second Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Hepatology and Surgery, The Second Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Infectious Disease, The Second Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, ChinaPegylated interferon alpha (Peg IFN-α) in combination with ribavirin is the backbone of treatment in chronic hepatitis C (CHC). Cardiotoxicity due to interferon therapy is rare. The most frequent cardiovascular complications are arrhythmias and ischemic manifestations. Cardiomyopathy is extremely rare but can be life threatening. We present the case of a 41-year-old female patient with CHC in whom Peg IFN-α induced dilated cardiomyopathy and hypothyroidism. Chest radiography showed an enlarged and globular cardiac silhouette and pulmonary congestion. Echocardiography showed decreased left ventricular systolic function with an ejection fraction of 32% and fractional shortening of 15%. Cardiomyopathy had a complete remission after cessation of antiviral therapy with short-term heart failure medications and supportive care. Then we review the current literature about interferon induced cardiomyopathy in patients with HCV infection, as well as share our clinical experience in diagnosing and managing this rare complication. Keywords: Pegylated interferon, Adverse drug reaction, Cardiotoxicity, Thyroid dysfunctionhttp://www.sciencedirect.com/science/article/pii/S1413867013002286 |
| spellingShingle | Wenxue Zhao Fanpu Ji Shanshan Yu Zongfang Li Hong Deng Dilated cardiomyopathy and hypothyroidism associated with pegylated interferon and ribavirin treatment for chronic hepatitis C: case report and literature review Brazilian Journal of Infectious Diseases |
| title | Dilated cardiomyopathy and hypothyroidism associated with pegylated interferon and ribavirin treatment for chronic hepatitis C: case report and literature review |
| title_full | Dilated cardiomyopathy and hypothyroidism associated with pegylated interferon and ribavirin treatment for chronic hepatitis C: case report and literature review |
| title_fullStr | Dilated cardiomyopathy and hypothyroidism associated with pegylated interferon and ribavirin treatment for chronic hepatitis C: case report and literature review |
| title_full_unstemmed | Dilated cardiomyopathy and hypothyroidism associated with pegylated interferon and ribavirin treatment for chronic hepatitis C: case report and literature review |
| title_short | Dilated cardiomyopathy and hypothyroidism associated with pegylated interferon and ribavirin treatment for chronic hepatitis C: case report and literature review |
| title_sort | dilated cardiomyopathy and hypothyroidism associated with pegylated interferon and ribavirin treatment for chronic hepatitis c case report and literature review |
| url | http://www.sciencedirect.com/science/article/pii/S1413867013002286 |
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