Uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patient
Uveitis is a rare adverse event of dupilumab, that typically affects both eyes and often leads to discontinuation of therapy. In this article, we report a case of a 28-year-old female with atopic dermatitis who developed new-onset iridocyclitis, a form of uveitis, in her left eye 2 weeks after start...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2023.2229466 |
| _version_ | 1797683505126178816 |
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| author | Shiyu Zhang Lu Lu Jindi Feng Zhonghui Hu Hongbin Song Lu Yang Yuehua Liu Di Chen Tao Wang |
| author_facet | Shiyu Zhang Lu Lu Jindi Feng Zhonghui Hu Hongbin Song Lu Yang Yuehua Liu Di Chen Tao Wang |
| author_sort | Shiyu Zhang |
| collection | DOAJ |
| description | Uveitis is a rare adverse event of dupilumab, that typically affects both eyes and often leads to discontinuation of therapy. In this article, we report a case of a 28-year-old female with atopic dermatitis who developed new-onset iridocyclitis, a form of uveitis, in her left eye 2 weeks after starting dupilumab treatment, which improved after reducing the dose, without discontinuing dupilumab. The patient also experienced asymptomatic hypereosinophilia, possibly related to dupilumab, which was gradually relieved without discontinuation. With the readers, we share our experience in managing uveitis and hypereosinophilia associated with dupilumab, which may be helpful in managing these conditions and avoiding discontinuation of dupilumab. |
| first_indexed | 2024-03-12T00:15:25Z |
| format | Article |
| id | doaj.art-de5112077edf43fa96d36c7f6b971c19 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:15:25Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-de5112077edf43fa96d36c7f6b971c192023-09-15T14:40:43ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532023-12-0134110.1080/09546634.2023.22294662229466Uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patientShiyu Zhang0Lu Lu1Jindi Feng2Zhonghui Hu3Hongbin Song4Lu Yang5Yuehua Liu6Di Chen7Tao Wang8Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic DiseasesDepartment of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic DiseasesDepartment of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic DiseasesDepartment of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic DiseasesDepartment of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic DiseasesDepartment of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic DiseasesDepartment of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic DiseasesDepartment of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic DiseasesUveitis is a rare adverse event of dupilumab, that typically affects both eyes and often leads to discontinuation of therapy. In this article, we report a case of a 28-year-old female with atopic dermatitis who developed new-onset iridocyclitis, a form of uveitis, in her left eye 2 weeks after starting dupilumab treatment, which improved after reducing the dose, without discontinuing dupilumab. The patient also experienced asymptomatic hypereosinophilia, possibly related to dupilumab, which was gradually relieved without discontinuation. With the readers, we share our experience in managing uveitis and hypereosinophilia associated with dupilumab, which may be helpful in managing these conditions and avoiding discontinuation of dupilumab.http://dx.doi.org/10.1080/09546634.2023.2229466dupilumabuveitishypereosinophiliaatopic dermatitisbiologics |
| spellingShingle | Shiyu Zhang Lu Lu Jindi Feng Zhonghui Hu Hongbin Song Lu Yang Yuehua Liu Di Chen Tao Wang Uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patient Journal of Dermatological Treatment dupilumab uveitis hypereosinophilia atopic dermatitis biologics |
| title | Uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patient |
| title_full | Uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patient |
| title_fullStr | Uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patient |
| title_full_unstemmed | Uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patient |
| title_short | Uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patient |
| title_sort | uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patient |
| topic | dupilumab uveitis hypereosinophilia atopic dermatitis biologics |
| url | http://dx.doi.org/10.1080/09546634.2023.2229466 |
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