Dysfunction of von-Hippel Lindau factor causes reduced degradation of HIF leading to renal cancer. Hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitors also lessen HIF destruction and could therefore increase renal cancer
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1170796/full |
| _version_ | 1797810603342954496 |
|---|---|
| author | Helge Waldum |
| author_facet | Helge Waldum |
| author_sort | Helge Waldum |
| collection | DOAJ |
| first_indexed | 2024-03-13T07:11:18Z |
| format | Article |
| id | doaj.art-de529764495a4b4da81efed4d22429bf |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-13T07:11:18Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-de529764495a4b4da81efed4d22429bf2023-06-06T04:28:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-06-011410.3389/fphar.2023.11707961170796Dysfunction of von-Hippel Lindau factor causes reduced degradation of HIF leading to renal cancer. Hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitors also lessen HIF destruction and could therefore increase renal cancerHelge Waldumhttps://www.frontiersin.org/articles/10.3389/fphar.2023.1170796/fullvon Hippel Lindau factorhypoxia inducible factor (HIF)renal cancerprolyl hydroxylase inhibitor (roxadustat)renal anemiaerythropoietin producing cell |
| spellingShingle | Helge Waldum Dysfunction of von-Hippel Lindau factor causes reduced degradation of HIF leading to renal cancer. Hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitors also lessen HIF destruction and could therefore increase renal cancer Frontiers in Pharmacology von Hippel Lindau factor hypoxia inducible factor (HIF) renal cancer prolyl hydroxylase inhibitor (roxadustat) renal anemia erythropoietin producing cell |
| title | Dysfunction of von-Hippel Lindau factor causes reduced degradation of HIF leading to renal cancer. Hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitors also lessen HIF destruction and could therefore increase renal cancer |
| title_full | Dysfunction of von-Hippel Lindau factor causes reduced degradation of HIF leading to renal cancer. Hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitors also lessen HIF destruction and could therefore increase renal cancer |
| title_fullStr | Dysfunction of von-Hippel Lindau factor causes reduced degradation of HIF leading to renal cancer. Hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitors also lessen HIF destruction and could therefore increase renal cancer |
| title_full_unstemmed | Dysfunction of von-Hippel Lindau factor causes reduced degradation of HIF leading to renal cancer. Hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitors also lessen HIF destruction and could therefore increase renal cancer |
| title_short | Dysfunction of von-Hippel Lindau factor causes reduced degradation of HIF leading to renal cancer. Hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitors also lessen HIF destruction and could therefore increase renal cancer |
| title_sort | dysfunction of von hippel lindau factor causes reduced degradation of hif leading to renal cancer hypoxia inducible factor prolyl hydroxylase enzyme inhibitors also lessen hif destruction and could therefore increase renal cancer |
| topic | von Hippel Lindau factor hypoxia inducible factor (HIF) renal cancer prolyl hydroxylase inhibitor (roxadustat) renal anemia erythropoietin producing cell |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1170796/full |
| work_keys_str_mv | AT helgewaldum dysfunctionofvonhippellindaufactorcausesreduceddegradationofhifleadingtorenalcancerhypoxiainduciblefactorprolylhydroxylaseenzymeinhibitorsalsolessenhifdestructionandcouldthereforeincreaserenalcancer |