The effects of edible bird’s nest on T-lymphocyte proliferation, secondary lymphoid organs, and interleukin-2 production
This study aimed to investigate the immunomodulatory effect of edible bird’s nest (EBN) in vitro and in vivo studies. EBN-treated peripheral blood mononuclear cells showed that EBN specifically enhanced the expansion of CD3+ T-cells. The restoration of lymphocyte subpopulations under the influence o...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622000470 |
| _version_ | 1819276102690930688 |
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| author | Theerawat Dobutr Wirapong Kantamala Suphaporn Phimwapi Nisachon Jangpromma Patcharaporn Tippayawat Sophon Boonlue Jureerut Daduang Sompong Klaynongsruang Saowanee Poopornchai Sakda Daduang |
| author_facet | Theerawat Dobutr Wirapong Kantamala Suphaporn Phimwapi Nisachon Jangpromma Patcharaporn Tippayawat Sophon Boonlue Jureerut Daduang Sompong Klaynongsruang Saowanee Poopornchai Sakda Daduang |
| author_sort | Theerawat Dobutr |
| collection | DOAJ |
| description | This study aimed to investigate the immunomodulatory effect of edible bird’s nest (EBN) in vitro and in vivo studies. EBN-treated peripheral blood mononuclear cells showed that EBN specifically enhanced the expansion of CD3+ T-cells. The restoration of lymphocyte subpopulations under the influence of immunosuppressive drug has been successfully recovered in CD3+ T-cells, not CD45RA+ B-cells and CD335+ NK-cells. In addition, oral administration of EBNs in Sprague-Dawley rats revealed their potential to increase the number of peripheral blood T-cells. Our study also demonstrated that EBN treatments affected the numbers of the Peyer’s patches, spleen weight and length, and cellularity of the periarteriolar lymphoid sheath. Interestingly, we observed that elevation of serum interleukin-2 (IL-2) had been correlated with the proliferation of T-cells in the animal model. Therefore, these results are essential for developing therapeutic strategies in improving immunity, particularly T-cell homeostasis, under immunosuppressive therapy. |
| first_indexed | 2024-12-23T23:34:53Z |
| format | Article |
| id | doaj.art-de52b175372643fcb3eb0e5c67f4f7ff |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-23T23:34:53Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-de52b175372643fcb3eb0e5c67f4f7ff2022-12-21T17:25:54ZengElsevierJournal of Functional Foods1756-46462022-03-0190104977The effects of edible bird’s nest on T-lymphocyte proliferation, secondary lymphoid organs, and interleukin-2 productionTheerawat Dobutr0Wirapong Kantamala1Suphaporn Phimwapi2Nisachon Jangpromma3Patcharaporn Tippayawat4Sophon Boonlue5Jureerut Daduang6Sompong Klaynongsruang7Saowanee Poopornchai8Sakda Daduang9Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen 40002, Thailand; Protein and Proteomics Research Center for Commercial and Industrial Purposes (ProCCI), Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand; Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandProtein and Proteomics Research Center for Commercial and Industrial Purposes (ProCCI), Faculty of Science, Khon Kaen University, Khon Kaen 40002, ThailandFaculty of Science, Khon Kaen University, Khon Kaen 40002, ThailandProtein and Proteomics Research Center for Commercial and Industrial Purposes (ProCCI), Faculty of Science, Khon Kaen University, Khon Kaen 40002, ThailandCentre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Microbiology, Faculty of Science, Khon Kaen University, Khon Kaen 40002, ThailandCentre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandProtein and Proteomics Research Center for Commercial and Industrial Purposes (ProCCI), Faculty of Science, Khon Kaen University, Khon Kaen 40002, ThailandAiko Edible Bird Nest Pattani, 44 M.3, T. Rhusamilae, Muang, Pattani 94000, ThailandProtein and Proteomics Research Center for Commercial and Industrial Purposes (ProCCI), Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand; Division of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand; Center for Research and Development of Herbal Health Products (CDR-HHP), Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand; Corresponding author at: Division of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.This study aimed to investigate the immunomodulatory effect of edible bird’s nest (EBN) in vitro and in vivo studies. EBN-treated peripheral blood mononuclear cells showed that EBN specifically enhanced the expansion of CD3+ T-cells. The restoration of lymphocyte subpopulations under the influence of immunosuppressive drug has been successfully recovered in CD3+ T-cells, not CD45RA+ B-cells and CD335+ NK-cells. In addition, oral administration of EBNs in Sprague-Dawley rats revealed their potential to increase the number of peripheral blood T-cells. Our study also demonstrated that EBN treatments affected the numbers of the Peyer’s patches, spleen weight and length, and cellularity of the periarteriolar lymphoid sheath. Interestingly, we observed that elevation of serum interleukin-2 (IL-2) had been correlated with the proliferation of T-cells in the animal model. Therefore, these results are essential for developing therapeutic strategies in improving immunity, particularly T-cell homeostasis, under immunosuppressive therapy.http://www.sciencedirect.com/science/article/pii/S1756464622000470Edible bird’s nestT-lymphocyte proliferationInterleukin-2Immunomodulation |
| spellingShingle | Theerawat Dobutr Wirapong Kantamala Suphaporn Phimwapi Nisachon Jangpromma Patcharaporn Tippayawat Sophon Boonlue Jureerut Daduang Sompong Klaynongsruang Saowanee Poopornchai Sakda Daduang The effects of edible bird’s nest on T-lymphocyte proliferation, secondary lymphoid organs, and interleukin-2 production Journal of Functional Foods Edible bird’s nest T-lymphocyte proliferation Interleukin-2 Immunomodulation |
| title | The effects of edible bird’s nest on T-lymphocyte proliferation, secondary lymphoid organs, and interleukin-2 production |
| title_full | The effects of edible bird’s nest on T-lymphocyte proliferation, secondary lymphoid organs, and interleukin-2 production |
| title_fullStr | The effects of edible bird’s nest on T-lymphocyte proliferation, secondary lymphoid organs, and interleukin-2 production |
| title_full_unstemmed | The effects of edible bird’s nest on T-lymphocyte proliferation, secondary lymphoid organs, and interleukin-2 production |
| title_short | The effects of edible bird’s nest on T-lymphocyte proliferation, secondary lymphoid organs, and interleukin-2 production |
| title_sort | effects of edible bird s nest on t lymphocyte proliferation secondary lymphoid organs and interleukin 2 production |
| topic | Edible bird’s nest T-lymphocyte proliferation Interleukin-2 Immunomodulation |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622000470 |
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