Sulfonamides complexed with metals as mycobacterial biofilms inhibitors
Rapidly growing mycobacteria (RGM) are found in non-sterile water and often associated with severe post-surgical infections and affect immunocompromised patients. In addition, RGM can prevent the host's immune response and have the ability to adhere to and form biofilms on biological and synthe...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-05-01
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| Series: | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405579421000061 |
| _version_ | 1818456562075697152 |
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| author | Pauline Cordenonsi Bonez Vanessa Albertina Agertt Grazielle Guidolin Rossi Fallon dos Santos Siqueira Josiéli Demétrio Siqueira Lenice Lorenço Marques Gelson Noe Manzoni de Oliveira Roberto Christ Vianna Santos Marli Matiko Anraku de Campos |
| author_facet | Pauline Cordenonsi Bonez Vanessa Albertina Agertt Grazielle Guidolin Rossi Fallon dos Santos Siqueira Josiéli Demétrio Siqueira Lenice Lorenço Marques Gelson Noe Manzoni de Oliveira Roberto Christ Vianna Santos Marli Matiko Anraku de Campos |
| author_sort | Pauline Cordenonsi Bonez |
| collection | DOAJ |
| description | Rapidly growing mycobacteria (RGM) are found in non-sterile water and often associated with severe post-surgical infections and affect immunocompromised patients. In addition, RGM can prevent the host's immune response and have the ability to adhere to and form biofilms on biological and synthetic substrates, making pharmacological treatment difficult because conventional antimicrobials are ineffective against biofilms. Thus, there is an urgent need for new antimicrobial compounds that can overcome these problems. In this context, sulfonamides complexed with Au, Cd, Ag, Cu, and Hg have shown excellent activity against various microorganisms. Considering the importance of combating RGM-associated infections, this study aimed to evaluate the activity of sulfonamide metal complexes against RGM biofilm. The sulfonamides were tested individually for their ability to inhibit mycobacterial formation and destroy the preformed biofilm of standard RGM strains, such as Mycobacterium abscessus, M. fortuitum, and M. massiliense. All sulfonamides complexed with metals could reduce, at subinhibitory concentrations, the adhesion and biofilm formation of three RGM species in polystyrene tubes. It is plausible that the anti-biofilm capacity of the compounds is due to the inhibition of c-di-GMP synthesis, which is an important signal for RGM biofilm formation. Hence, the impacts and scientific contribution of this study are based on the discovery of a potential new therapeutic option against RGM-associated biofilm infections. Sulfonamides complexed with metals have proven to be a useful and promising tool to reduce microbial adhesion on inert surfaces, stimulating the improvement of methodologies to insert compounds as new antibacterial and coating agents for medical and hospital materials. |
| first_indexed | 2024-12-14T22:28:38Z |
| format | Article |
| id | doaj.art-de52e538892d4b688d18965e9179d88e |
| institution | Directory Open Access Journal |
| issn | 2405-5794 |
| language | English |
| last_indexed | 2024-12-14T22:28:38Z |
| publishDate | 2021-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
| spelling | doaj.art-de52e538892d4b688d18965e9179d88e2022-12-21T22:45:17ZengElsevierJournal of Clinical Tuberculosis and Other Mycobacterial Diseases2405-57942021-05-0123100217Sulfonamides complexed with metals as mycobacterial biofilms inhibitorsPauline Cordenonsi Bonez0Vanessa Albertina Agertt1Grazielle Guidolin Rossi2Fallon dos Santos Siqueira3Josiéli Demétrio Siqueira4Lenice Lorenço Marques5Gelson Noe Manzoni de Oliveira6Roberto Christ Vianna Santos7Marli Matiko Anraku de Campos8Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, 1000 Avenida Roraima, 97105900 Santa Maria, RS, Brazil; Corresponding author.Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, 1000 Avenida Roraima, 97105900 Santa Maria, RS, BrazilPrograma de Pós-graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, 1000 Avenida Roraima, 97105900 Santa Maria, RS, BrazilPrograma de Pós-graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, 1000 Avenida Roraima, 97105900 Santa Maria, RS, BrazilCentro de Ciências Naturais e Exatas, Departamento de Química, Universidade Federal de Santa Maria, 1000 Avenida Roraima, 9710597 Santa Maria, RS, BrazilCentro de Ciências Naturais e Exatas, Departamento de Química, Universidade Federal de Santa Maria, 1000 Avenida Roraima, 9710597 Santa Maria, RS, BrazilCentro de Ciências Naturais e Exatas, Departamento de Química, Universidade Federal de Santa Maria, 1000 Avenida Roraima, 9710597 Santa Maria, RS, BrazilPrograma de Pós-graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, 1000 Avenida Roraima, 97105900 Santa Maria, RS, BrazilPrograma de Pós-graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, 1000 Avenida Roraima, 97105900 Santa Maria, RS, BrazilRapidly growing mycobacteria (RGM) are found in non-sterile water and often associated with severe post-surgical infections and affect immunocompromised patients. In addition, RGM can prevent the host's immune response and have the ability to adhere to and form biofilms on biological and synthetic substrates, making pharmacological treatment difficult because conventional antimicrobials are ineffective against biofilms. Thus, there is an urgent need for new antimicrobial compounds that can overcome these problems. In this context, sulfonamides complexed with Au, Cd, Ag, Cu, and Hg have shown excellent activity against various microorganisms. Considering the importance of combating RGM-associated infections, this study aimed to evaluate the activity of sulfonamide metal complexes against RGM biofilm. The sulfonamides were tested individually for their ability to inhibit mycobacterial formation and destroy the preformed biofilm of standard RGM strains, such as Mycobacterium abscessus, M. fortuitum, and M. massiliense. All sulfonamides complexed with metals could reduce, at subinhibitory concentrations, the adhesion and biofilm formation of three RGM species in polystyrene tubes. It is plausible that the anti-biofilm capacity of the compounds is due to the inhibition of c-di-GMP synthesis, which is an important signal for RGM biofilm formation. Hence, the impacts and scientific contribution of this study are based on the discovery of a potential new therapeutic option against RGM-associated biofilm infections. Sulfonamides complexed with metals have proven to be a useful and promising tool to reduce microbial adhesion on inert surfaces, stimulating the improvement of methodologies to insert compounds as new antibacterial and coating agents for medical and hospital materials.http://www.sciencedirect.com/science/article/pii/S2405579421000061Rapidly growing mycobacteriaSulfonamidesMetalsBiofilmc-di-GMP |
| spellingShingle | Pauline Cordenonsi Bonez Vanessa Albertina Agertt Grazielle Guidolin Rossi Fallon dos Santos Siqueira Josiéli Demétrio Siqueira Lenice Lorenço Marques Gelson Noe Manzoni de Oliveira Roberto Christ Vianna Santos Marli Matiko Anraku de Campos Sulfonamides complexed with metals as mycobacterial biofilms inhibitors Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Rapidly growing mycobacteria Sulfonamides Metals Biofilm c-di-GMP |
| title | Sulfonamides complexed with metals as mycobacterial biofilms inhibitors |
| title_full | Sulfonamides complexed with metals as mycobacterial biofilms inhibitors |
| title_fullStr | Sulfonamides complexed with metals as mycobacterial biofilms inhibitors |
| title_full_unstemmed | Sulfonamides complexed with metals as mycobacterial biofilms inhibitors |
| title_short | Sulfonamides complexed with metals as mycobacterial biofilms inhibitors |
| title_sort | sulfonamides complexed with metals as mycobacterial biofilms inhibitors |
| topic | Rapidly growing mycobacteria Sulfonamides Metals Biofilm c-di-GMP |
| url | http://www.sciencedirect.com/science/article/pii/S2405579421000061 |
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