Asthma is inversely associated with Helicobacter pylori status in an urban population.
Microbial exposures have been suggested to confer protection from allergic disorders and reduced exposures to gastrointestinal microbiota have been proposed as an explanation for the increase in asthma prevalence. Since the general prevalence of Helicobacter pylori has been decreasing, we hypothesiz...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2008-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2603593?pdf=render |
| _version_ | 1818984823302127616 |
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| author | Joan Reibman Michael Marmor Joshua Filner Maria-Elena Fernandez-Beros Linda Rogers Guillermo I Perez-Perez Martin J Blaser |
| author_facet | Joan Reibman Michael Marmor Joshua Filner Maria-Elena Fernandez-Beros Linda Rogers Guillermo I Perez-Perez Martin J Blaser |
| author_sort | Joan Reibman |
| collection | DOAJ |
| description | Microbial exposures have been suggested to confer protection from allergic disorders and reduced exposures to gastrointestinal microbiota have been proposed as an explanation for the increase in asthma prevalence. Since the general prevalence of Helicobacter pylori has been decreasing, we hypothesized that H. pylori serostatus would be inversely related to the presence of asthma.Adults were recruited to participate in the New York University (NYU)/Bellevue Asthma Registry in New York City. Adult asthma cases (N = 318) and controls (N = 208) were identified and serum IgG antibodies to H. pylori whole cell antigens or the immunodominant CagA antigen were measured.As expected, the asthma cases and controls differed with respect to atopy and lung function. Seropositivity to H. pylori or CagA antigen was present in 47.1% of the total case and control study population. Asthma was inversely associated with CagA seropositivity (OR = 0.57, 95% CI = 0.36-0.89). Median age of onset of asthma (doctor's diagnosis) was older (21 years) among individuals with CagA+ strains than among H. pylori- individuals (11 years) (p = 0.006).These data are consistent with the hypothesis that colonization with CagA+ H. pylori strains is inversely associated with asthma and is associated with an older age of asthma onset in an urban population. The data suggest H. pylori as a marker for protection. |
| first_indexed | 2024-12-20T18:25:07Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T18:25:07Z |
| publishDate | 2008-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-de53e5b1cad94f769550fac5855a3aea2022-12-21T19:30:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032008-01-01312e406010.1371/journal.pone.0004060Asthma is inversely associated with Helicobacter pylori status in an urban population.Joan ReibmanMichael MarmorJoshua FilnerMaria-Elena Fernandez-BerosLinda RogersGuillermo I Perez-PerezMartin J BlaserMicrobial exposures have been suggested to confer protection from allergic disorders and reduced exposures to gastrointestinal microbiota have been proposed as an explanation for the increase in asthma prevalence. Since the general prevalence of Helicobacter pylori has been decreasing, we hypothesized that H. pylori serostatus would be inversely related to the presence of asthma.Adults were recruited to participate in the New York University (NYU)/Bellevue Asthma Registry in New York City. Adult asthma cases (N = 318) and controls (N = 208) were identified and serum IgG antibodies to H. pylori whole cell antigens or the immunodominant CagA antigen were measured.As expected, the asthma cases and controls differed with respect to atopy and lung function. Seropositivity to H. pylori or CagA antigen was present in 47.1% of the total case and control study population. Asthma was inversely associated with CagA seropositivity (OR = 0.57, 95% CI = 0.36-0.89). Median age of onset of asthma (doctor's diagnosis) was older (21 years) among individuals with CagA+ strains than among H. pylori- individuals (11 years) (p = 0.006).These data are consistent with the hypothesis that colonization with CagA+ H. pylori strains is inversely associated with asthma and is associated with an older age of asthma onset in an urban population. The data suggest H. pylori as a marker for protection.http://europepmc.org/articles/PMC2603593?pdf=render |
| spellingShingle | Joan Reibman Michael Marmor Joshua Filner Maria-Elena Fernandez-Beros Linda Rogers Guillermo I Perez-Perez Martin J Blaser Asthma is inversely associated with Helicobacter pylori status in an urban population. PLoS ONE |
| title | Asthma is inversely associated with Helicobacter pylori status in an urban population. |
| title_full | Asthma is inversely associated with Helicobacter pylori status in an urban population. |
| title_fullStr | Asthma is inversely associated with Helicobacter pylori status in an urban population. |
| title_full_unstemmed | Asthma is inversely associated with Helicobacter pylori status in an urban population. |
| title_short | Asthma is inversely associated with Helicobacter pylori status in an urban population. |
| title_sort | asthma is inversely associated with helicobacter pylori status in an urban population |
| url | http://europepmc.org/articles/PMC2603593?pdf=render |
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