Targeting the DEAD-Box RNA Helicase eIF4A with Rocaglates—A Pan-Antiviral Strategy for Minimizing the Impact of Future RNA Virus Pandemics

Targeting the DEAD-Box RNA Helicase eIF4A with Rocaglates—A Pan-Antiviral Strategy for Minimizing the Impact of Future RNA Virus Pandemics

The increase in pandemics caused by RNA viruses of zoonotic origin highlights the urgent need for broad-spectrum antivirals against novel and re-emerging RNA viruses. Broad-spectrum antivirals could be deployed as first-line interventions during an outbreak while virus-specific drugs and vaccines ar...

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Bibliographic Details
Main Authors: Gaspar Taroncher-Oldenburg, Christin Müller, Wiebke Obermann, John Ziebuhr, Roland K. Hartmann, Arnold Grünweller
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Microorganisms
Subjects:
pan-antiviral
rocaglates
eIF4A
silvestrol
CR-31-B
Zotatifin
Online Access:https://www.mdpi.com/2076-2607/9/3/540

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